Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype.

This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases...

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Detalhes bibliográficos
Autores: Lope, V, Guerrero-Zotano, A, Casas, A, Baena-Canada, JM, Bermejo, B, Perez-Gomez, B, Criado-Navarro, I, Antolin, S, Sanchez-Rovira, P, Ramos-Vazquez, M, Anton, A, Castello, A, Garcia-Saenz, JA, Munoz, M, de Juan, A, Andres, R, Llombart-Cussac, A, Hernando, B, Franquesa, RM, Caballero, R, Priego-Capote, F, Martin, M, Pollan, M
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p10887
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/10887
Access Level:acceso abierto
Palavra-chave:EpiGEICAM
breast cancer subtypes
breast neoplasm
desaturation indices
fats
Descrição
Resumo:This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)(T3vsT)(1) = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (OR(T3vsT)(1) = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-?-linolenic acid ratio (OR (T3vsT)(1) = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (OR(T3vsT)(1) = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (OR(T3vsT)(1) = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (OR(T3vsT)(1) = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (OR(T3vsT)(1) = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.

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