Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex

The human dorsolateral prefrontal cortex (dlPFC) is crucial for monitoring and manipulating information in working memory, but whether such contributions are domain-specific remains unsettled. Neuroimaging studies have shown bilateral dlPFC activity associated with working memory independent of stim...

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Detalles Bibliográficos
Autores: Fried, Peter J., Rushmore, Richard Jarrett, Moss, Mark B., Valero-Cabré, Antoni, Pascual Leone, Álvaro
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2014
País:España
Institución:Universitat Oberta de Catalunya (UOC)
Repositorio:O2, repositorio institucional de la UOC
OAI Identifier:oai:openaccess.uoc.edu:10609/109847
Acceso en línea:https://hdl.handle.net/10609/109847
Access Level:acceso abierto
Palabra clave:rTMS
dlPFC
working memory
functional specialization
functional neuroanatomy
memòria funcional
especialització funcional
neuroanatomia funcional
memoria funcional
especialización funcional
neuroanatomía funcional
Neurosciences
Neurociències
Neurociencia
id ES_59ea6fc00b5727d136f497cb746ec5fd
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortexFried, Peter J.Rushmore, Richard JarrettMoss, Mark B.Valero-Cabré, AntoniPascual Leone, ÁlvarorTMSdlPFCworking memoryfunctional specializationfunctional neuroanatomyrTMSdlPFCmemòria funcionalespecialització funcionalneuroanatomia funcionalrTMSdlPFCmemoria funcionalespecialización funcionalneuroanatomía funcionalNeurosciencesNeurociènciesNeurocienciaThe human dorsolateral prefrontal cortex (dlPFC) is crucial for monitoring and manipulating information in working memory, but whether such contributions are domain-specific remains unsettled. Neuroimaging studies have shown bilateral dlPFC activity associated with working memory independent of stimulus domain, but the causality of this relationship cannot be inferred. Repetitive transcranial magnetic stimulation (rTMS) has the potential to test whether the left and right dlPFC contribute equally to verbal and spatial domains, however this is the first study to investigate the interaction of task domain and hemisphere using offline rTMS to temporarily modulate dlPFC activity. In separate sessions, twenty healthy right-handed adults received 1HzrTMS to left dlPFC, right dlPFC, plus the vertex as a control site. Working memory performance was assessed pre- and post-rTMS using both verbal-'letter' and spatial-'location' versions of the 3-back task. Response times were faster post-rTMS, independent of task domain or stimulation condition, indicating the influence of practice or other nonspecific effects. For accuracy, rTMS of the right dlPFC, but not the left dlPFC or vertex, led to a transient dissociation: reducing spatial, but increasing verbal accuracy. A post-hoc correlation analysis found no relationship between these changes indicating the substrates underlying verbal and spatial domains are functionally independent. Collapsing across time, there was a trend towards a double dissociation, suggesting a potential laterality in functional organization of verbal and spatial working memory. At a minimum, these findings provide human evidence for domain-specific contributions of the dlPFC to working memory and reinforce the potential of rTMS to ameliorate cognition.European Journal of NeuroscienceBoston University School of MedicineBerenson-Allen Center for Noninvasive Brain StimulationUniversitat Oberta de Catalunya (UOC)202020202014info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10609/109847reponame:O2, repositorio institucional de la UOCinstname:Universitat Oberta de Catalunya (UOC)InglésEuropean Journal of Neuroscience, 2014, 39(11)https://doi.org/10.1111/ejn.12584info:eu-repo/grantAgreement/UL1 RR025758//info:eu-repo/grantAgreement/NS062317//CC BY-NC-NDhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:openaccess.uoc.edu:10609/1098472026-05-28T12:42:01Z
dc.title.none.fl_str_mv Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex
title Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex
spellingShingle Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex
Fried, Peter J.
rTMS
dlPFC
working memory
functional specialization
functional neuroanatomy
rTMS
dlPFC
memòria funcional
especialització funcional
neuroanatomia funcional
rTMS
dlPFC
memoria funcional
especialización funcional
neuroanatomía funcional
Neurosciences
Neurociències
Neurociencia
title_short Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex
title_full Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex
title_fullStr Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex
title_full_unstemmed Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex
title_sort Causal evidence supporting functional dissociation of verbal and spatial working memory in the human dorsolateral prefrontal cortex
dc.creator.none.fl_str_mv Fried, Peter J.
Rushmore, Richard Jarrett
Moss, Mark B.
Valero-Cabré, Antoni
Pascual Leone, Álvaro
author Fried, Peter J.
author_facet Fried, Peter J.
Rushmore, Richard Jarrett
Moss, Mark B.
Valero-Cabré, Antoni
Pascual Leone, Álvaro
author_role author
author2 Rushmore, Richard Jarrett
Moss, Mark B.
Valero-Cabré, Antoni
Pascual Leone, Álvaro
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Boston University School of Medicine
Berenson-Allen Center for Noninvasive Brain Stimulation
Universitat Oberta de Catalunya (UOC)
dc.subject.none.fl_str_mv rTMS
dlPFC
working memory
functional specialization
functional neuroanatomy
rTMS
dlPFC
memòria funcional
especialització funcional
neuroanatomia funcional
rTMS
dlPFC
memoria funcional
especialización funcional
neuroanatomía funcional
Neurosciences
Neurociències
Neurociencia
topic rTMS
dlPFC
working memory
functional specialization
functional neuroanatomy
rTMS
dlPFC
memòria funcional
especialització funcional
neuroanatomia funcional
rTMS
dlPFC
memoria funcional
especialización funcional
neuroanatomía funcional
Neurosciences
Neurociències
Neurociencia
description The human dorsolateral prefrontal cortex (dlPFC) is crucial for monitoring and manipulating information in working memory, but whether such contributions are domain-specific remains unsettled. Neuroimaging studies have shown bilateral dlPFC activity associated with working memory independent of stimulus domain, but the causality of this relationship cannot be inferred. Repetitive transcranial magnetic stimulation (rTMS) has the potential to test whether the left and right dlPFC contribute equally to verbal and spatial domains, however this is the first study to investigate the interaction of task domain and hemisphere using offline rTMS to temporarily modulate dlPFC activity. In separate sessions, twenty healthy right-handed adults received 1HzrTMS to left dlPFC, right dlPFC, plus the vertex as a control site. Working memory performance was assessed pre- and post-rTMS using both verbal-'letter' and spatial-'location' versions of the 3-back task. Response times were faster post-rTMS, independent of task domain or stimulation condition, indicating the influence of practice or other nonspecific effects. For accuracy, rTMS of the right dlPFC, but not the left dlPFC or vertex, led to a transient dissociation: reducing spatial, but increasing verbal accuracy. A post-hoc correlation analysis found no relationship between these changes indicating the substrates underlying verbal and spatial domains are functionally independent. Collapsing across time, there was a trend towards a double dissociation, suggesting a potential laterality in functional organization of verbal and spatial working memory. At a minimum, these findings provide human evidence for domain-specific contributions of the dlPFC to working memory and reinforce the potential of rTMS to ameliorate cognition.
publishDate 2014
dc.date.none.fl_str_mv 2014
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10609/109847
url https://hdl.handle.net/10609/109847
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv European Journal of Neuroscience, 2014, 39(11)
https://doi.org/10.1111/ejn.12584
info:eu-repo/grantAgreement/UL1 RR025758//
info:eu-repo/grantAgreement/NS062317//
dc.rights.none.fl_str_mv CC BY-NC-ND
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC BY-NC-ND
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv European Journal of Neuroscience
publisher.none.fl_str_mv European Journal of Neuroscience
dc.source.none.fl_str_mv reponame:O2, repositorio institucional de la UOC
instname:Universitat Oberta de Catalunya (UOC)
instname_str Universitat Oberta de Catalunya (UOC)
reponame_str O2, repositorio institucional de la UOC
collection O2, repositorio institucional de la UOC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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