Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat diet

Insulin resistance (IR) produces qualitative, quantitative and kinetic changes of lipoproteins in Type 2 Diabetes Mellitus (T2DM). Carob-fruit-extract (CFE) has demonstrated antidiabetic properties but barely studies have evaluated the effect of CFE functional-meat consumption on early stages of T2D...

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Autores: Macho González, Adrián, Garcimartín Álvarez, Alba, López-Oliva Muñoz, María Elvira, Celada, Paloma, Bastida Codina, Sara, Benedí González, Juana María, Sánchez-Muniz, Francisco José, Sánchez Muniz, Francisco José
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/116329
Acceso en línea:https://hdl.handle.net/20.500.14352/116329
Access Level:acceso abierto
Palabra clave:612.39
615
663/665
Diabetes
Carob fruit
Functional meat
Lipoproteins
Insulin signaling
Dietética y nutrición (Farmacia)
Bioquímica (Farmacia)
Tecnología de los alimentos
3206 Ciencias de la Nutrición
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oai_identifier_str oai:docta.ucm.es:20.500.14352/116329
network_acronym_str ES
network_name_str España
repository_id_str
spelling Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat dietMacho González, AdriánGarcimartín Álvarez, AlbaLópez-Oliva Muñoz, María ElviraCelada, PalomaBastida Codina, SaraBenedí González, Juana MaríaSánchez-Muniz, Francisco JoséSánchez Muniz, Francisco José612.39615663/665DiabetesCarob fruitFunctional meatLipoproteinsInsulin signalingDietética y nutrición (Farmacia)Bioquímica (Farmacia)Tecnología de los alimentos3206 Ciencias de la NutriciónInsulin resistance (IR) produces qualitative, quantitative and kinetic changes of lipoproteins in Type 2 Diabetes Mellitus (T2DM). Carob-fruit-extract (CFE) has demonstrated antidiabetic properties but barely studies have evaluated the effect of CFE functional-meat consumption on early stages of T2DM. The current study was designed to analyze the effect of CFE-enriched meat-consumption on lipemia, lipoprotein profile and its relation with IR in T2DM model. Sixteen Wistar rats were divided in: C group, fed high-saturated-fat diet with commercial meat; and CE group, fed high-saturated-fat diet containing CFE-enriched meat. After 8-weeks, C rats showed hyperglycemia, hyperinsulinemia, hypertriglyceridemia and increased triglyceride-enriched-VLDL compared to CE animals (p < 0.05). CE group was able to partially block diabetic dyslipidemia and reduce HOMA-IR by showing higher PI3K, pAKTser473, GLUT2 and LDL-receptor levels versus their C counterparts (p ≤ 0.020). In conclusion, CFE-enriched meat-consumption strongly counterbalanced diabetic dyslipidemia by improving insulin signaling, suggesting its being an adequate functional ingredient for T2DM.ElservierUniversidad Complutense de Madrid20202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/116329reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1163292026-06-02T12:44:21Z
dc.title.none.fl_str_mv Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat diet
title Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat diet
spellingShingle Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat diet
Macho González, Adrián
612.39
615
663/665
Diabetes
Carob fruit
Functional meat
Lipoproteins
Insulin signaling
Dietética y nutrición (Farmacia)
Bioquímica (Farmacia)
Tecnología de los alimentos
3206 Ciencias de la Nutrición
title_short Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat diet
title_full Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat diet
title_fullStr Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat diet
title_full_unstemmed Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat diet
title_sort Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat diet
dc.creator.none.fl_str_mv Macho González, Adrián
Garcimartín Álvarez, Alba
López-Oliva Muñoz, María Elvira
Celada, Paloma
Bastida Codina, Sara
Benedí González, Juana María
Sánchez-Muniz, Francisco José
Sánchez Muniz, Francisco José
author Macho González, Adrián
author_facet Macho González, Adrián
Garcimartín Álvarez, Alba
López-Oliva Muñoz, María Elvira
Celada, Paloma
Bastida Codina, Sara
Benedí González, Juana María
Sánchez-Muniz, Francisco José
Sánchez Muniz, Francisco José
author_role author
author2 Garcimartín Álvarez, Alba
López-Oliva Muñoz, María Elvira
Celada, Paloma
Bastida Codina, Sara
Benedí González, Juana María
Sánchez-Muniz, Francisco José
Sánchez Muniz, Francisco José
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.39
615
663/665
Diabetes
Carob fruit
Functional meat
Lipoproteins
Insulin signaling
Dietética y nutrición (Farmacia)
Bioquímica (Farmacia)
Tecnología de los alimentos
3206 Ciencias de la Nutrición
topic 612.39
615
663/665
Diabetes
Carob fruit
Functional meat
Lipoproteins
Insulin signaling
Dietética y nutrición (Farmacia)
Bioquímica (Farmacia)
Tecnología de los alimentos
3206 Ciencias de la Nutrición
description Insulin resistance (IR) produces qualitative, quantitative and kinetic changes of lipoproteins in Type 2 Diabetes Mellitus (T2DM). Carob-fruit-extract (CFE) has demonstrated antidiabetic properties but barely studies have evaluated the effect of CFE functional-meat consumption on early stages of T2DM. The current study was designed to analyze the effect of CFE-enriched meat-consumption on lipemia, lipoprotein profile and its relation with IR in T2DM model. Sixteen Wistar rats were divided in: C group, fed high-saturated-fat diet with commercial meat; and CE group, fed high-saturated-fat diet containing CFE-enriched meat. After 8-weeks, C rats showed hyperglycemia, hyperinsulinemia, hypertriglyceridemia and increased triglyceride-enriched-VLDL compared to CE animals (p < 0.05). CE group was able to partially block diabetic dyslipidemia and reduce HOMA-IR by showing higher PI3K, pAKTser473, GLUT2 and LDL-receptor levels versus their C counterparts (p ≤ 0.020). In conclusion, CFE-enriched meat-consumption strongly counterbalanced diabetic dyslipidemia by improving insulin signaling, suggesting its being an adequate functional ingredient for T2DM.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/116329
url https://hdl.handle.net/20.500.14352/116329
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elservier
publisher.none.fl_str_mv Elservier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408643126919168
score 15.812455

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