Carob-fruit-extract-enriched meat modulates lipoprotein metabolism and insulin signaling in diabetic rats induced by high-saturated-fat diet

Insulin resistance (IR) produces qualitative, quantitative and kinetic changes of lipoproteins in Type 2 Diabetes Mellitus (T2DM). Carob-fruit-extract (CFE) has demonstrated antidiabetic properties but barely studies have evaluated the effect of CFE functional-meat consumption on early stages of T2D...

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Bibliographic Details
Authors: Macho González, Adrián, Garcimartín Álvarez, Alba, López-Oliva Muñoz, María Elvira, Celada, Paloma, Bastida Codina, Sara, Benedí González, Juana María, Sánchez-Muniz, Francisco José, Sánchez Muniz, Francisco José
Format: article
Publication Date:2020
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/116329
Online Access:https://hdl.handle.net/20.500.14352/116329
Access Level:Open access
Keyword:612.39
615
663/665
Diabetes
Carob fruit
Functional meat
Lipoproteins
Insulin signaling
Dietética y nutrición (Farmacia)
Bioquímica (Farmacia)
Tecnología de los alimentos
3206 Ciencias de la Nutrición
Description
Summary:Insulin resistance (IR) produces qualitative, quantitative and kinetic changes of lipoproteins in Type 2 Diabetes Mellitus (T2DM). Carob-fruit-extract (CFE) has demonstrated antidiabetic properties but barely studies have evaluated the effect of CFE functional-meat consumption on early stages of T2DM. The current study was designed to analyze the effect of CFE-enriched meat-consumption on lipemia, lipoprotein profile and its relation with IR in T2DM model. Sixteen Wistar rats were divided in: C group, fed high-saturated-fat diet with commercial meat; and CE group, fed high-saturated-fat diet containing CFE-enriched meat. After 8-weeks, C rats showed hyperglycemia, hyperinsulinemia, hypertriglyceridemia and increased triglyceride-enriched-VLDL compared to CE animals (p < 0.05). CE group was able to partially block diabetic dyslipidemia and reduce HOMA-IR by showing higher PI3K, pAKTser473, GLUT2 and LDL-receptor levels versus their C counterparts (p ≤ 0.020). In conclusion, CFE-enriched meat-consumption strongly counterbalanced diabetic dyslipidemia by improving insulin signaling, suggesting its being an adequate functional ingredient for T2DM.

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