One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial
Background: Choline and betaine intakes have been related to cardiovascular health. Objectives: We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvencion con D...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p14650 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/14650 |
| Access Level: | acceso abierto |
| Palabra clave: | choline betaine Mediterranean diet cardiovasculardisease risk cardiometabolic parameters renal variables?????????????? |
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One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trialDiez-Ricote, LSan-Cristobal, RConcejo, MJMartinez-Gonzalez, MACorella, DSalas-Salvado, JGoday, AMartinez, JAAlonso-Gomez, AMWaernberg, JVioque, JRomaguera, DLopez-Miranda, JEstruch, RTinahones, FJLapetra, JSerra-Majem, LBueno-Cavanillas, ATur, JASanchez, VMPinto, XGaforio, JJMatia-Martin, PVidal, JFontao, SMRos, EVazquez-Ruiz, ZOrtega-Azorin, CGarcia-Gavilan, JFMalcampo, MMartinez-Urbistondo, DTojal-Sierra, LRodriguez, AGGomez-Bellvert, NChaplin, AGarcia-Rios, ABernal-Lopez, RMSantos-Lozano, JMBasterra-Gortari, JSorli, JVMurphy, MGasulla, GMico, VSalaverria-Lete, IOchandorena, EGBabio, NHerraiz, XOrdovas, JMDaimiel, LcholinebetaineMediterranean dietcardiovasculardisease riskcardiometabolic parametersrenal variables??????????????Background: Choline and betaine intakes have been related to cardiovascular health. Objectives: We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvencion con DIeta MEDiterranea)-Plus trial. Methods: We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean & PLUSMN; SD age: 65.01 & PLUSMN; 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMED-Plus trial. Participants met & GE;3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m(2)) & GE;27 and & LE;40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of choline and betaine were estimated from the FFQ. Results: The greatest 1-y increase in dietary choline or betaine intake (quartile 4) was associated with improved serum glucose concentrations (-3.39 and -2.72 mg/dL for choline and betaine, respectively) and HbA1c levels (-0.10% for quartile 4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were reduced body weight (-2.93 and -2.78 kg, respectively), BMI (-1.05 and -0.99, respectively), waist circumference (-3.37 and -3.26 cm, respectively), total cholesterol (-4.74 and -4.52 mg/dL, respectively), and LDL cholesterol (-4.30 and -4.16 mg/dL, respectively). Urine creatinine was reduced in quartile 4 of 1-y increase in choline or betaine intake (-5.42 and -5.74 mg/dL, respectively). Conclusions: Increases in dietary choline or betaine intakes were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they require further investigation.This trial was registered at as ISRCTN89898870.ELSEVIER SCIENCE INC2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/14650AMERICAN JOURNAL OF CLINICAL NUTRITIONISSN: 00029165ISSNe: 19383207reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p146502026-06-11T12:45:17Z |
| dc.title.none.fl_str_mv |
One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial |
| title |
One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial |
| spellingShingle |
One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial Diez-Ricote, L choline betaine Mediterranean diet cardiovasculardisease risk cardiometabolic parameters renal variables?????????????? |
| title_short |
One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial |
| title_full |
One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial |
| title_fullStr |
One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial |
| title_full_unstemmed |
One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial |
| title_sort |
One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial |
| dc.creator.none.fl_str_mv |
Diez-Ricote, L San-Cristobal, R Concejo, MJ Martinez-Gonzalez, MA Corella, D Salas-Salvado, J Goday, A Martinez, JA Alonso-Gomez, AM Waernberg, J Vioque, J Romaguera, D Lopez-Miranda, J Estruch, R Tinahones, FJ Lapetra, J Serra-Majem, L Bueno-Cavanillas, A Tur, JA Sanchez, VM Pinto, X Gaforio, JJ Matia-Martin, P Vidal, J Fontao, SM Ros, E Vazquez-Ruiz, Z Ortega-Azorin, C Garcia-Gavilan, JF Malcampo, M Martinez-Urbistondo, D Tojal-Sierra, L Rodriguez, AG Gomez-Bellvert, N Chaplin, A Garcia-Rios, A Bernal-Lopez, RM Santos-Lozano, JM Basterra-Gortari, J Sorli, JV Murphy, M Gasulla, G Mico, V Salaverria-Lete, I Ochandorena, EG Babio, N Herraiz, X Ordovas, JM Daimiel, L |
| author |
Diez-Ricote, L |
| author_facet |
Diez-Ricote, L San-Cristobal, R Concejo, MJ Martinez-Gonzalez, MA Corella, D Salas-Salvado, J Goday, A Martinez, JA Alonso-Gomez, AM Waernberg, J Vioque, J Romaguera, D Lopez-Miranda, J Estruch, R Tinahones, FJ Lapetra, J Serra-Majem, L Bueno-Cavanillas, A Tur, JA Sanchez, VM Pinto, X Gaforio, JJ Matia-Martin, P Vidal, J Fontao, SM Ros, E Vazquez-Ruiz, Z Ortega-Azorin, C Garcia-Gavilan, JF Malcampo, M Martinez-Urbistondo, D Tojal-Sierra, L Rodriguez, AG Gomez-Bellvert, N Chaplin, A Garcia-Rios, A Bernal-Lopez, RM Santos-Lozano, JM Basterra-Gortari, J Sorli, JV Murphy, M Gasulla, G Mico, V Salaverria-Lete, I Ochandorena, EG Babio, N Herraiz, X Ordovas, JM Daimiel, L |
| author_role |
author |
| author2 |
San-Cristobal, R Concejo, MJ Martinez-Gonzalez, MA Corella, D Salas-Salvado, J Goday, A Martinez, JA Alonso-Gomez, AM Waernberg, J Vioque, J Romaguera, D Lopez-Miranda, J Estruch, R Tinahones, FJ Lapetra, J Serra-Majem, L Bueno-Cavanillas, A Tur, JA Sanchez, VM Pinto, X Gaforio, JJ Matia-Martin, P Vidal, J Fontao, SM Ros, E Vazquez-Ruiz, Z Ortega-Azorin, C Garcia-Gavilan, JF Malcampo, M Martinez-Urbistondo, D Tojal-Sierra, L Rodriguez, AG Gomez-Bellvert, N Chaplin, A Garcia-Rios, A Bernal-Lopez, RM Santos-Lozano, JM Basterra-Gortari, J Sorli, JV Murphy, M Gasulla, G Mico, V Salaverria-Lete, I Ochandorena, EG Babio, N Herraiz, X Ordovas, JM Daimiel, L |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
choline betaine Mediterranean diet cardiovasculardisease risk cardiometabolic parameters renal variables?????????????? |
| topic |
choline betaine Mediterranean diet cardiovasculardisease risk cardiometabolic parameters renal variables?????????????? |
| description |
Background: Choline and betaine intakes have been related to cardiovascular health. Objectives: We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvencion con DIeta MEDiterranea)-Plus trial. Methods: We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean & PLUSMN; SD age: 65.01 & PLUSMN; 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMED-Plus trial. Participants met & GE;3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m(2)) & GE;27 and & LE;40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of choline and betaine were estimated from the FFQ. Results: The greatest 1-y increase in dietary choline or betaine intake (quartile 4) was associated with improved serum glucose concentrations (-3.39 and -2.72 mg/dL for choline and betaine, respectively) and HbA1c levels (-0.10% for quartile 4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were reduced body weight (-2.93 and -2.78 kg, respectively), BMI (-1.05 and -0.99, respectively), waist circumference (-3.37 and -3.26 cm, respectively), total cholesterol (-4.74 and -4.52 mg/dL, respectively), and LDL cholesterol (-4.30 and -4.16 mg/dL, respectively). Urine creatinine was reduced in quartile 4 of 1-y increase in choline or betaine intake (-5.42 and -5.74 mg/dL, respectively). Conclusions: Increases in dietary choline or betaine intakes were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they require further investigation.This trial was registered at as ISRCTN89898870. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://fisabio.portalinvestigacion.com/publicaciones/14650 |
| url |
https://fisabio.portalinvestigacion.com/publicaciones/14650 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
ELSEVIER SCIENCE INC |
| publisher.none.fl_str_mv |
ELSEVIER SCIENCE INC |
| dc.source.none.fl_str_mv |
AMERICAN JOURNAL OF CLINICAL NUTRITION ISSN: 00029165 ISSNe: 19383207 reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| instname_str |
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| reponame_str |
r-FISABIO. Repositorio Institucional de Producción Científica |
| collection |
r-FISABIO. Repositorio Institucional de Producción Científica |
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|
| repository.mail.fl_str_mv |
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1869408587187486720 |
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15,811543 |