One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial

Choline and betaine intakes have been related to cardiovascular health. We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvención con DIeta MEDiterránea)-Plus...

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Autores: Díez-Ricote, Laura, San-Cristobal, Rodrigo, Concejo, M José, Martínez González, Miguel Ángel|||0000-0002-3917-9808, Corella, Dolores|||0000-0002-2366-4104, Salas-Salvadó, Jordi|||0000-0003-2700-7459, Goday Arnó, Albert|||0000-0001-7356-1595, Martínez, J Alfredo, Alonso-Gómez, Ángel María|||0000-0003-2945-7509, Wärnberg, Julia|||0000-0002-8408-316X, Vioque, Jesús|||0000-0002-2284-148X, Romaguera, Dora|||0000-0002-5762-8558, López-Miranda, José|||0000-0002-8844-0718, Estruch, Ramón|||0000-0003-1260-4445, Tinahones, Francisco J.|||0000-0001-6871-4403, Lapetra, José|||0000-0002-3873-5737, Serra-Majem, Luís|||0000-0002-9658-9061, Bueno-Cavanillas, Aurora|||0000-0002-0649-3016, Tur, Josep Antonio|||0000-0002-6940-0761, Martín, Vicente|||0000-0003-0552-2804, Pintó, Xavier|||0000-0002-2216-2444, Gaforio, José J.|||0000-0003-2996-9301, Matía-Martín, Pilar|||0000-0001-9844-3755, Vidal, Josep|||0000-0002-4564-4518, Mas, Sebastian|||0000-0001-6604-3327, Ros, Emilio|||0000-0002-2573-1294, Vázquez-Ruiz, Zenaida|||0000-0002-6828-9627, Ortega-Azorín, Carolina|||0000-0001-6719-9358, García-Gavilán, Jesús F., Malcampo Manrúbia, Mireia|||0000-0002-1916-4537, Martínez-Urbistondo, Diego, Tojal-Sierra, Lucas|||0000-0001-5338-9601, García Rodríguez, Antonio, Gómez-Bellvert, Nuria, Chaplin, Alice, García-Rios, Antonio|||0000-0001-7320-9006, Bernal-López, Rosa M., Santos-Lozano, José M., Basterra Gortari, Francisco Javier|||0000-0002-1506-2349, Sorlí, José V.|||0000-0002-0130-2006, Murphy, Michelle, Gasulla, Griselda|||0000-0003-4018-5786, Micó, Víctor, Salaverria-Lete, Itziar|||0000-0002-9504-4668, Goñi Ochandorena, Estibaliz, Babio, Nancy|||0000-0003-3527-5277, Herraiz, Xavier, Ordovás, José M., Daimiel, Lidia|||0000-0001-9898-6629
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:281740
Acceso en línea:https://ddd.uab.cat/record/281740
https://dx.doi.org/urn:doi:10.1093/ajcn/nqac255
Access Level:acceso abierto
Palabra clave:Betaine
Cardiovascular disease risk
Cardiometabolic parameters
Choline
Mediterranean diet
Renal variables
Descripción
Sumario:Choline and betaine intakes have been related to cardiovascular health. We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial. We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean ± SD age: 65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMED-Plus trial. Participants met ≥3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m 2) ≥27 and ≤40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of choline and betaine were estimated from the FFQ. The greatest 1-y increase in dietary choline or betaine intake (quartile 4) was associated with improved serum glucose concentrations (-3.39 and -2.72 mg/dL for choline and betaine, respectively) and HbA1c levels (-0.10% for quartile 4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were reduced body weight (-2.93 and -2.78 kg, respectively), BMI (-1.05 and -0.99, respectively), waist circumference (-3.37 and -3.26 cm, respectively), total cholesterol (-4.74 and -4.52 mg/dL, respectively), and LDL cholesterol (-4.30 and -4.16 mg/dL, respectively). Urine creatinine was reduced in quartile 4 of 1-y increase in choline or betaine intake (-5.42 and -5.74 mg/dL, respectively). Increases in dietary choline or betaine intakes were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they require further investigation. This trial was registered at as ISRCTN89898870.

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