fabH deletion increases DHA production in Escherichia coli expressing Pfa genes
[Background]: Some marine bacteria, such as Moritella marina, produce the nutraceutical docosahexaenoic acid (DHA) thanks to a specifc enzymatic complex called Pfa synthase. Escherichia coli heterologously expressing the pfa gene cluster from M. marina also produces DHA. The aim of this study was to...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/189716 |
| Acceso en línea: | http://hdl.handle.net/10261/189716 |
| Access Level: | acceso abierto |
| Palabra clave: | Fatty acid synthesis Polyunsaturated fatty acids Docosahexaenoic acid Cerulenin FabH |
| Sumario: | [Background]: Some marine bacteria, such as Moritella marina, produce the nutraceutical docosahexaenoic acid (DHA) thanks to a specifc enzymatic complex called Pfa synthase. Escherichia coli heterologously expressing the pfa gene cluster from M. marina also produces DHA. The aim of this study was to fnd genetic or metabolic conditions to increase DHA production in E. coli. |
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