Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA study
Background: Atherosclerosis has been linked to cognitive decline in late life; however, the impact of cardiovascular risk factors (CVRFs) and subclinical atherosclerosis on brain metabolism at earlier stages remains unexplored. Objectives: This study sought to determine the association between brain...
| Autores: | , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/48069 |
| Acceso en línea: | http://hdl.handle.net/10230/48069 http://dx.doi.org/10.1016/j.jacc.2020.12.027 |
| Access Level: | acceso abierto |
| Palabra clave: | (18)F-fluorodeoxyglucose-positron emission tomography Alzheimer’s disease Cardiovascular risk Dementia Hypertension Statistical parametric mapping |
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Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA study |
| title |
Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA study |
| spellingShingle |
Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA study Cortés Canteli, Marta (18)F-fluorodeoxyglucose-positron emission tomography Alzheimer’s disease Cardiovascular risk Dementia Hypertension Statistical parametric mapping |
| title_short |
Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA study |
| title_full |
Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA study |
| title_fullStr |
Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA study |
| title_full_unstemmed |
Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA study |
| title_sort |
Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA study |
| dc.creator.none.fl_str_mv |
Cortés Canteli, Marta Gispert, Juan Domingo Salvadó, Gemma Toribio Fernández, Raquel Tristão Pereira, Catarina Falcón, Carles Oliva, Belén Mendiguren, José Fernández Friera, Letícia Sanz, Javier García-Ruiz de Morales, José María Fernández Ortiz, Antonio Sánchez González, Javier Ibáñez, Borja Molinuevo, José Luis Fuster, Valentín |
| author |
Cortés Canteli, Marta |
| author_facet |
Cortés Canteli, Marta Gispert, Juan Domingo Salvadó, Gemma Toribio Fernández, Raquel Tristão Pereira, Catarina Falcón, Carles Oliva, Belén Mendiguren, José Fernández Friera, Letícia Sanz, Javier García-Ruiz de Morales, José María Fernández Ortiz, Antonio Sánchez González, Javier Ibáñez, Borja Molinuevo, José Luis Fuster, Valentín |
| author_role |
author |
| author2 |
Gispert, Juan Domingo Salvadó, Gemma Toribio Fernández, Raquel Tristão Pereira, Catarina Falcón, Carles Oliva, Belén Mendiguren, José Fernández Friera, Letícia Sanz, Javier García-Ruiz de Morales, José María Fernández Ortiz, Antonio Sánchez González, Javier Ibáñez, Borja Molinuevo, José Luis Fuster, Valentín |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
(18)F-fluorodeoxyglucose-positron emission tomography Alzheimer’s disease Cardiovascular risk Dementia Hypertension Statistical parametric mapping |
| topic |
(18)F-fluorodeoxyglucose-positron emission tomography Alzheimer’s disease Cardiovascular risk Dementia Hypertension Statistical parametric mapping |
| description |
Background: Atherosclerosis has been linked to cognitive decline in late life; however, the impact of cardiovascular risk factors (CVRFs) and subclinical atherosclerosis on brain metabolism at earlier stages remains unexplored. Objectives: This study sought to determine the association between brain metabolism, subclinical atherosclerosis, and CVRFs in middle-aged asymptomatic individuals. Methods: This study included 547 asymptomatic middle-aged participants (50 ± 4 years, 82% men) from the PESA (Progression of Early Subclinical Atherosclerosis) study with evidence of subclinical atherosclerosis. Participants underwent 18F-fluorodeoxyglucose (FDG)-positron emission tomography. Global brain FDG uptake and voxel-wise analyses were used to evaluate the associations of cerebral metabolism with CVRFs and atherosclerotic plaque burden in carotids and femorals assessed by 3-dimensional vascular ultrasound. Results: Global FDG uptake showed an inverse correlation with 30-year Framingham Risk Score (FRS) (β = -0.15, p < 0.001). This association was mainly driven by the presence of hypertension (d = 0.36, p < 0.001). Carotid plaque burden was inversely associated with global brain FDG uptake (β = -0.16, p < 0.001), even after adjusting for 30-year FRS. Voxel-wise approaches revealed that the brain areas most strongly affected by hypometabolism in association with 30-year FRS, hypertension, and carotid plaque burden were parietotemporal regions (angular, supramarginal, and inferior/middle temporal gyri) and the cingulate gyrus. Conclusions: In asymptomatic middle-aged individuals, cardiovascular risk is associated with brain hypometabolism, with hypertension being the modifiable CVRF showing the strongest association. Subclinical carotid plaque burden is also linked to reduced brain metabolism independently of CVRFs. Cerebral areas showing hypometabolism include those known to be affected in dementia. These data reinforce the need to control CVRFs early in life in order to potentially reduce the brain's midlife vulnerability to future cognitive dysfunction. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/48069 http://dx.doi.org/10.1016/j.jacc.2020.12.027 |
| url |
http://hdl.handle.net/10230/48069 http://dx.doi.org/10.1016/j.jacc.2020.12.027 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
J Am Coll Cardiol. 2021;77(7):888-98 info:eu-repo/grantAgreement/EC/H2020/819775 info:eu-repo/grantAgreement/EC/FP7/115736 info:eu-repo/grantAgreement/EC/H2020/115952 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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Repositorio Digital de la UPF |
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1869408576968065024 |
| spelling |
Subclinical atherosclerosis and brain metabolism in middle-aged individuals: The PESA studyCortés Canteli, MartaGispert, Juan DomingoSalvadó, GemmaToribio Fernández, RaquelTristão Pereira, CatarinaFalcón, CarlesOliva, BelénMendiguren, JoséFernández Friera, LetíciaSanz, JavierGarcía-Ruiz de Morales, José MaríaFernández Ortiz, AntonioSánchez González, JavierIbáñez, BorjaMolinuevo, José LuisFuster, Valentín(18)F-fluorodeoxyglucose-positron emission tomographyAlzheimer’s diseaseCardiovascular riskDementiaHypertensionStatistical parametric mappingBackground: Atherosclerosis has been linked to cognitive decline in late life; however, the impact of cardiovascular risk factors (CVRFs) and subclinical atherosclerosis on brain metabolism at earlier stages remains unexplored. Objectives: This study sought to determine the association between brain metabolism, subclinical atherosclerosis, and CVRFs in middle-aged asymptomatic individuals. Methods: This study included 547 asymptomatic middle-aged participants (50 ± 4 years, 82% men) from the PESA (Progression of Early Subclinical Atherosclerosis) study with evidence of subclinical atherosclerosis. Participants underwent 18F-fluorodeoxyglucose (FDG)-positron emission tomography. Global brain FDG uptake and voxel-wise analyses were used to evaluate the associations of cerebral metabolism with CVRFs and atherosclerotic plaque burden in carotids and femorals assessed by 3-dimensional vascular ultrasound. Results: Global FDG uptake showed an inverse correlation with 30-year Framingham Risk Score (FRS) (β = -0.15, p < 0.001). This association was mainly driven by the presence of hypertension (d = 0.36, p < 0.001). Carotid plaque burden was inversely associated with global brain FDG uptake (β = -0.16, p < 0.001), even after adjusting for 30-year FRS. Voxel-wise approaches revealed that the brain areas most strongly affected by hypometabolism in association with 30-year FRS, hypertension, and carotid plaque burden were parietotemporal regions (angular, supramarginal, and inferior/middle temporal gyri) and the cingulate gyrus. Conclusions: In asymptomatic middle-aged individuals, cardiovascular risk is associated with brain hypometabolism, with hypertension being the modifiable CVRF showing the strongest association. Subclinical carotid plaque burden is also linked to reduced brain metabolism independently of CVRFs. Cerebral areas showing hypometabolism include those known to be affected in dementia. These data reinforce the need to control CVRFs early in life in order to potentially reduce the brain's midlife vulnerability to future cognitive dysfunction.The study also receives funding from the Instituto de Salud Carlos III, Madrid, Spain (ISCIII, PI15/02019), the European Regional Development Fund (ERDF–A Way to Build Europe) and the European Social Fund (ESF–Investing in Your Future). Dr. Cortes-Canteli was supported by a Miguel Servet type I research contract (ISCIII, CP16/00174 & MS16/00174) and the Fondo de Investigación Sanitaria (ISCIII, PI17/00590 & PI20/00819). Dr. Toribio-Fernandez was supported by the Iniciativa de Empleo Juvenil of the Consejería de Educación, Juventud y Deporte de la Comunidad de Madrid (PEJD-2018-POST/BMD-9259). Ms. Tristão-Pereira was supported by a “la Caixa” Foundation fellowship (ID 100010434, LCF/BQ/DI19/11730052). Dr. Gispert is supported by the Ministerio de Ciencia e Innovación (MCIN; RYC-2013-13054) and Dr. B. Ibanez by the European Research Council (ERC-2018-CoG 819775-MATRIX). The CNIC is supported by the ISCIII, the MCIN, and the Pro-CNIC Foundation. The BBRC is mainly funded by the “la Caixa” Foundation (ID 100010434) under agreement LCF/PR/GN17/50300004, the EU/EFPIA Innovative Medicines Initiative Joint Undertaking EPAD under grant agreement 115736, and the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement 115952. This Joint Undertaking receives support from the European Union Horizon 2020 Research and Innovation Programme and the EFPIA. Dr. Molinuevo has served as a consultant for, sat on advisory boards of, or delivered lectures in symposia sponsored by Roche Diagnostics, Genentech, Novartis, Lundbeck, Oryzon, Biogen, Lilly, Janssen, Green Valley, MSD, Eisai, Alector, BioCross, GE Healthcare, and ProMIS Neurosciences. Dr. Gispert has given lectures in symposia sponsored by General Electric, Philips, and Biogen. Dr. Sanchez-Gonzalez is a Philips employee. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.Elsevier202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48069http://dx.doi.org/10.1016/j.jacc.2020.12.027reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJ Am Coll Cardiol. 2021;77(7):888-98info:eu-repo/grantAgreement/EC/H2020/819775info:eu-repo/grantAgreement/EC/FP7/115736info:eu-repo/grantAgreement/EC/H2020/115952© 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an openaccess article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/480692026-06-12T07:21:37Z |
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15,811543 |