Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia

Background: The clinical course following a first episode of schizophrenia (FES) is often characterized by recurrent relapses, resulting in unfavorable clinical and functional outcomes. Inflammatory dysregulation has been implicated in relapse risk; however, the predictive value of inflammatory bloo...

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Autores: Llorca-Bofí, Vicent, Madero Gómez, Santiago, Amoretti Guadall, Silvia, Cuesta, Manuel J., Moreno, Carmen, González Pinto, Ana, Bergé, Daniel, Rodriguez Jimenez, Roberto, Roldán, Alexandra, García León, María Ángeles, Ibáñez Cuadrado, Ángela, Usall i Rodié, Judith, Contreras, Fernando, Mezquida Mateos, Gisela, García Rizo, Clemente, Berrocoso, Esther, Bernardo Vilamitjana, Mercè, Bioque Alcázar, Miquel
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/218986
Acesso em linha:https://hdl.handle.net/2445/218986
Access Level:acceso abierto
Palavra-chave:Esquizofrènia
Psicosi
Inflamació
Cèl·lules sanguínies
Schizophrenia
Psychoses
Inflammation
Blood cells
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spelling Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophreniaLlorca-Bofí, VicentMadero Gómez, SantiagoAmoretti Guadall, SilviaCuesta, Manuel J.Moreno, CarmenGonzález Pinto, AnaBergé, DanielRodriguez Jimenez, RobertoRoldán, AlexandraGarcía León, María ÁngelesIbáñez Cuadrado, ÁngelaUsall i Rodié, JudithContreras, FernandoMezquida Mateos, GiselaGarcía Rizo, ClementeBerrocoso, EstherBernardo Vilamitjana, MercèBioque Alcázar, MiquelEsquizofrèniaPsicosiInflamacióCèl·lules sanguíniesSchizophreniaPsychosesInflammationBlood cellsBackground: The clinical course following a first episode of schizophrenia (FES) is often characterized by recurrent relapses, resulting in unfavorable clinical and functional outcomes. Inflammatory dysregulation has been implicated in relapse risk; however, the predictive value of inflammatory blood cells in clinically remitted patients after a FES has not been previously explored. Methods: In this study, we closely monitored 111 patients in remission after a FES until relapse or a three-year follow-up endpoint. The participants were recruited from the multicenter 2EPS Project. Data on inflammatory blood cells and ratios were collected at baseline and at the time of relapse or after three years of follow-up. Results: Monocyte counts (OR = 1.91; 95 % CI = 1.07-3.18; p = 0.009) and basophil counts (OR = 1.09; 95 % CI = 1.01-1.12; p = 0.005) at baseline were associated with an increased risk of relapse, while the platelet-lymphocyte ratio (OR = 0.98; 95 % CI = 0.97-0.99; p = 0.019) was identified as a protective factor. However, after adjusting for cannabis and tobacco use during the follow-up, only monocyte counts (OR = 1.73; 95 % CI = 1.03-2.29; p = 0.027) and basophil counts (OR = 1.08; 95 % CI = 1.01-1.14; p = 0.008) remained statistically significant. ROC curve analysis indicated that the optimal cut-off values for discriminating relapsers were 0.52 × 10^9/L (AUC: 0.66) for monocytes and 0.025 × 10^9/L (AUC: 0.75) for basophils. When considering baseline inflammatory levels, no significant differences were observed in the inflammatory biomarkers at the endpoint between relapsers and non-relapsers. Conclusion: This study provides evidence that higher monocyte and basophil counts measured at remission after a FES are associated with an increased risk of relapse during a three-year follow-up period.Elsevier B.V.2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/218986Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.schres.2024.03.011Schizophrenia Research, 2024, vol. 267, p. 24-31https://doi.org/10.1016/j.schres.2024.03.011cc-by-nc-nd (c) Elsevier B.V., 2024http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2189862026-05-27T06:46:51Z
dc.title.none.fl_str_mv Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia
title Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia
spellingShingle Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia
Llorca-Bofí, Vicent
Esquizofrènia
Psicosi
Inflamació
Cèl·lules sanguínies
Schizophrenia
Psychoses
Inflammation
Blood cells
title_short Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia
title_full Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia
title_fullStr Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia
title_full_unstemmed Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia
title_sort Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia
dc.creator.none.fl_str_mv Llorca-Bofí, Vicent
Madero Gómez, Santiago
Amoretti Guadall, Silvia
Cuesta, Manuel J.
Moreno, Carmen
González Pinto, Ana
Bergé, Daniel
Rodriguez Jimenez, Roberto
Roldán, Alexandra
García León, María Ángeles
Ibáñez Cuadrado, Ángela
Usall i Rodié, Judith
Contreras, Fernando
Mezquida Mateos, Gisela
García Rizo, Clemente
Berrocoso, Esther
Bernardo Vilamitjana, Mercè
Bioque Alcázar, Miquel
author Llorca-Bofí, Vicent
author_facet Llorca-Bofí, Vicent
Madero Gómez, Santiago
Amoretti Guadall, Silvia
Cuesta, Manuel J.
Moreno, Carmen
González Pinto, Ana
Bergé, Daniel
Rodriguez Jimenez, Roberto
Roldán, Alexandra
García León, María Ángeles
Ibáñez Cuadrado, Ángela
Usall i Rodié, Judith
Contreras, Fernando
Mezquida Mateos, Gisela
García Rizo, Clemente
Berrocoso, Esther
Bernardo Vilamitjana, Mercè
Bioque Alcázar, Miquel
author_role author
author2 Madero Gómez, Santiago
Amoretti Guadall, Silvia
Cuesta, Manuel J.
Moreno, Carmen
González Pinto, Ana
Bergé, Daniel
Rodriguez Jimenez, Roberto
Roldán, Alexandra
García León, María Ángeles
Ibáñez Cuadrado, Ángela
Usall i Rodié, Judith
Contreras, Fernando
Mezquida Mateos, Gisela
García Rizo, Clemente
Berrocoso, Esther
Bernardo Vilamitjana, Mercè
Bioque Alcázar, Miquel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Esquizofrènia
Psicosi
Inflamació
Cèl·lules sanguínies
Schizophrenia
Psychoses
Inflammation
Blood cells
topic Esquizofrènia
Psicosi
Inflamació
Cèl·lules sanguínies
Schizophrenia
Psychoses
Inflammation
Blood cells
description Background: The clinical course following a first episode of schizophrenia (FES) is often characterized by recurrent relapses, resulting in unfavorable clinical and functional outcomes. Inflammatory dysregulation has been implicated in relapse risk; however, the predictive value of inflammatory blood cells in clinically remitted patients after a FES has not been previously explored. Methods: In this study, we closely monitored 111 patients in remission after a FES until relapse or a three-year follow-up endpoint. The participants were recruited from the multicenter 2EPS Project. Data on inflammatory blood cells and ratios were collected at baseline and at the time of relapse or after three years of follow-up. Results: Monocyte counts (OR = 1.91; 95 % CI = 1.07-3.18; p = 0.009) and basophil counts (OR = 1.09; 95 % CI = 1.01-1.12; p = 0.005) at baseline were associated with an increased risk of relapse, while the platelet-lymphocyte ratio (OR = 0.98; 95 % CI = 0.97-0.99; p = 0.019) was identified as a protective factor. However, after adjusting for cannabis and tobacco use during the follow-up, only monocyte counts (OR = 1.73; 95 % CI = 1.03-2.29; p = 0.027) and basophil counts (OR = 1.08; 95 % CI = 1.01-1.14; p = 0.008) remained statistically significant. ROC curve analysis indicated that the optimal cut-off values for discriminating relapsers were 0.52 × 10^9/L (AUC: 0.66) for monocytes and 0.025 × 10^9/L (AUC: 0.75) for basophils. When considering baseline inflammatory levels, no significant differences were observed in the inflammatory biomarkers at the endpoint between relapsers and non-relapsers. Conclusion: This study provides evidence that higher monocyte and basophil counts measured at remission after a FES are associated with an increased risk of relapse during a three-year follow-up period.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/218986
url https://hdl.handle.net/2445/218986
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.schres.2024.03.011
Schizophrenia Research, 2024, vol. 267, p. 24-31
https://doi.org/10.1016/j.schres.2024.03.011
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2024
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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