Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de investigación, si le hubiere, y los autores pertenecientes a la UAM

Detalles Bibliográficos
Autores: Magro Hernández, Raúl, Ynsa Alcalá, María Dolores, Tavares De Sousa, Célia, Cortés Llanos, Belén, García López, Gastón, Manso Silván, Miguel, Viñals i Onses, Silvia
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/718428
Acceso en línea:http://hdl.handle.net/10486/718428
https://dx.doi.org/10.1039/d4tb01391c
Access Level:acceso abierto
Palabra clave:Nanoparticles
Proton Irradiation
Radiotherapy
Física
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spelling Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapyMagro Hernández, RaúlYnsa Alcalá, María DoloresTavares De Sousa, CéliaCortés Llanos, BelénGarcía López, GastónManso Silván, MiguelViñals i Onses, SilviaNanoparticlesProton IrradiationRadiotherapyFísicaArtículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de investigación, si le hubiere, y los autores pertenecientes a la UAMOsteosarcoma is a radioresistant cancer, and proton therapy is a promising radiation alternative for treating cancer with the advantage of a high dose concentration in the tumor area. In this work, we propose the use of iodine-substituted hydroxyapatite (IHAP) nanomaterials to use iodine (127I) as a proton radiation tracer, providing access to range verification studies in mineralized tissues. For this purpose, the nanomaterials were synthesized at four iodine concentrations via hydrothermal synthesis. The materials were characterized via different microstructural techniques to identify an optimal high iodine concentration and pure apatite phase nanomaterial. Finally, such pure IHAP powders were shaped and irradiated with proton beams of 6 and 10 MeV, and their activation was demonstrated through subsequent decay analysis. The materials could be integrated into phantom structures for the verification of doses and ranges of protons prior to animal testing and clinical proton therapy treatments of tumors located deep under combined soft and calcified tissuesThe current research was funded through grants PID2020-112770RB-C21, PDC2022-133382-I00, PID2020-112770RB-C22 and PID2023-151371OB-C22 by MCIN/AEI/10.13039/501100011033 and FEDER, EU, grant FLASHOnChip (PLEC2022-009256) by MCIN, ASAP-CM (P2022/BMD-7434) from DGI-Comunidad de Madrid and CIPROM/2021/064 from Generalitat Valenciana. Beamtime at the CMAM through experiment EUB004/22 is acknowledgedRSCDepartamento de Física AplicadaFacultad de Ciencias20242024-10-15research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/718428https://dx.doi.org/10.1039/d4tb01391creponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7184282026-06-23T12:46:27Z
dc.title.none.fl_str_mv Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy
title Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy
spellingShingle Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy
Magro Hernández, Raúl
Nanoparticles
Proton Irradiation
Radiotherapy
Física
title_short Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy
title_full Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy
title_fullStr Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy
title_full_unstemmed Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy
title_sort Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy
dc.creator.none.fl_str_mv Magro Hernández, Raúl
Ynsa Alcalá, María Dolores
Tavares De Sousa, Célia
Cortés Llanos, Belén
García López, Gastón
Manso Silván, Miguel
Viñals i Onses, Silvia
author Magro Hernández, Raúl
author_facet Magro Hernández, Raúl
Ynsa Alcalá, María Dolores
Tavares De Sousa, Célia
Cortés Llanos, Belén
García López, Gastón
Manso Silván, Miguel
Viñals i Onses, Silvia
author_role author
author2 Ynsa Alcalá, María Dolores
Tavares De Sousa, Célia
Cortés Llanos, Belén
García López, Gastón
Manso Silván, Miguel
Viñals i Onses, Silvia
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Física Aplicada
Facultad de Ciencias
dc.subject.none.fl_str_mv Nanoparticles
Proton Irradiation
Radiotherapy
Física
topic Nanoparticles
Proton Irradiation
Radiotherapy
Física
description Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de investigación, si le hubiere, y los autores pertenecientes a la UAM
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-10-15
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/718428
https://dx.doi.org/10.1039/d4tb01391c
url http://hdl.handle.net/10486/718428
https://dx.doi.org/10.1039/d4tb01391c
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv RSC
publisher.none.fl_str_mv RSC
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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