Iodine-substituted hydroxyapatite nanoparticles and activation of derived ceramics for range verification in proton therapy

Osteosarcoma is a radioresistant cancer, and proton therapy is a promising radiation alternative for treating cancer with the advantage of a high dose concentration in the tumor area. In this work, we propose the use of iodine-substituted hydroxyapatite (IHAP) nanomaterials to use iodine (127I) as a...

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Bibliographic Details
Authors: Magro Hernández, Raúl, Muñoz Noval, Alvaro, Briz, José Antonio, Rodríguez Murias, Javier, Espinosa Rodríguez, Andrea, Fraile, Luis Mario, Agulló Rueda, Fernando, Ynsa, Maria Dolores, Tavares de Sousa, Célia, Cortés Llanos, Belén, García López, Gastón, Nacher González, Enrique, García Távora, Vicente, Mont i Geli, Nil|||0000-0003-4249-7281, Nerio Aguirre, Amanda, Valladolid Onecha, Víctor, Pallàs i Solís, Max|||0000-0001-6137-0812, Tarifeño Saldivia, Ariel, Tengblad, Olof Erik, Manso Silvan, Miguel, Viñals Onsens, Silvia
Format: article
Publication Date:2024
Country:España
Institution:Universitat Politècnica de Catalunya (UPC)
Repository:UPCommons. Portal del coneixement obert de la UPC
Language:English
OAI Identifier:oai:upcommons.upc.edu:2117/419848
Online Access:https://hdl.handle.net/2117/419848
https://dx.doi.org/10.1039/d4tb01391c
Access Level:Open access
Keyword:Osteosarcoma
Iodine -- Therapeutic use
Iode -- Ús terapèutic
Àrees temàtiques de la UPC::Ciències de la salut
Àrees temàtiques de la UPC::Enginyeria química
Description
Summary:Osteosarcoma is a radioresistant cancer, and proton therapy is a promising radiation alternative for treating cancer with the advantage of a high dose concentration in the tumor area. In this work, we propose the use of iodine-substituted hydroxyapatite (IHAP) nanomaterials to use iodine (127I) as a proton radiation tracer, providing access to range verification studies in mineralized tissues. For this purpose, the nanomaterials were synthesized at four iodine concentrations via hydrothermal synthesis. The materials were characterized via different microstructural techniques to identify an optimal high iodine concentration and pure apatite phase nanomaterial. Finally, such pure IHAP powders were shaped and irradiated with proton beams of 6 and 10 MeV, and their activation was demonstrated through subsequent decay analysis. The materials could be integrated into phantom structures for the verification of doses and ranges of protons prior to animal testing and clinical proton therapy treatments of tumors located deep under combined soft and calcified tissues.

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