Activación y Señalización del Receptor del Complemento CR3
Integrins lie at the core of many critical immunobiological processes, ranging from regulating the formation of immunological synapses and antigenic presentation to phagocytosis. The Complement Receptors CR3/αMβ2 and CR4/αXβ2 are endowed with ability to engulf and dispose mainly of complement-opsoni...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/88750 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/88750 |
| Access Level: | acceso abierto |
| Palabra clave: | 612.017(043.2) Immunity Inmunidad Inmunología 2412 Inmunología |
| Sumario: | Integrins lie at the core of many critical immunobiological processes, ranging from regulating the formation of immunological synapses and antigenic presentation to phagocytosis. The Complement Receptors CR3/αMβ2 and CR4/αXβ2 are endowed with ability to engulf and dispose mainly of complement-opsonized particles, thereby being involved in pathogen elimination, apoptotic cell clearance and removal of cellular debris. Therefore, these receptors contribute to both immunity and tissue homeostasis. Research in the field of integrin-mediated phagocytosis has shed light on the molecular events controlling integrin activation and their effector functions. Activation of these receptors is dependent on signals derived from cytokine receptors as well as receptors sensing molecular patterns associated with either pathogens, cellular damage or stress. This process is termed inside-out signaling, and critically involves the recruitment of Talin to the cytoplasmic tails of the integrin β subunit, which is mediated by Rap1 activation and RIAM binding. In contrast to inside-out signaling, outside-in signaling describes the molecular events downstream integrin activation and remains less explored for these receptors... |
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