Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents

This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of the American Chemical Society, copyright © American Chemical Society after peer review. To access the final edited and published work see http://doi.org/10.1021/jacs.7b0527...

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Detalles Bibliográficos
Autores: Guisán-Ceinos, Manuel, Martín-Heras, Víctor, Tortosa Manzanares, Mariola
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/680857
Acceso en línea:http://hdl.handle.net/10486/680857
https://dx.doi.org/10.1021/jacs.7b05273
Access Level:acceso abierto
Palabra clave:aryl Grignard reagents
experimental procedures
crystal structural data
cooper salt
Química
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spelling Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagentsGuisán-Ceinos, ManuelMartín-Heras, VíctorTortosa Manzanares, Mariolaaryl Grignard reagentsexperimental procedurescrystal structural datacooper saltQuímicaThis document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of the American Chemical Society, copyright © American Chemical Society after peer review. To access the final edited and published work see http://doi.org/10.1021/jacs.7b05273We have developed a copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents. The reaction is stereospecific and α-regioselective and proceeds with exceptional functional group tolerance. Conveniently, a stable, inexpensive, and commercially available copper salt is used and no added ligand is requiredWe thank the European Research Council (ERC-337776) and MINECO (CTQ2016-78779-R) for financial support. M.T. thanks MICINN for a RyC contractAmerican Chemical SocietyDepartamento de Química OrgánicaFacultad de Ciencias20172017-06-28research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/680857https://dx.doi.org/10.1021/jacs.7b05273reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Framework Programme Seven 337776open accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6808572026-06-23T12:46:27Z
dc.title.none.fl_str_mv Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents
title Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents
spellingShingle Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents
Guisán-Ceinos, Manuel
aryl Grignard reagents
experimental procedures
crystal structural data
cooper salt
Química
title_short Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents
title_full Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents
title_fullStr Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents
title_full_unstemmed Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents
title_sort Regio- and stereospecific copper-catalyzed substitution reaction of propargylic ammonium salts with aryl Grignard reagents
dc.creator.none.fl_str_mv Guisán-Ceinos, Manuel
Martín-Heras, Víctor
Tortosa Manzanares, Mariola
author Guisán-Ceinos, Manuel
author_facet Guisán-Ceinos, Manuel
Martín-Heras, Víctor
Tortosa Manzanares, Mariola
author_role author
author2 Martín-Heras, Víctor
Tortosa Manzanares, Mariola
author2_role author
author
dc.contributor.none.fl_str_mv Departamento de Química Orgánica
Facultad de Ciencias
dc.subject.none.fl_str_mv aryl Grignard reagents
experimental procedures
crystal structural data
cooper salt
Química
topic aryl Grignard reagents
experimental procedures
crystal structural data
cooper salt
Química
description This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of the American Chemical Society, copyright © American Chemical Society after peer review. To access the final edited and published work see http://doi.org/10.1021/jacs.7b05273
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-06-28
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/680857
https://dx.doi.org/10.1021/jacs.7b05273
url http://hdl.handle.net/10486/680857
https://dx.doi.org/10.1021/jacs.7b05273
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Framework Programme Seven 337776
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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