Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening

Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Detalles Bibliográficos
Autores: Martín Sánchez, Vicente, Fernández Villa, Tania, Carvajal Urueña, Ana María, Rivero Rodríguez, Ana María, Reguero Celada, Sofía, Sánchez Antolín, Gloria, Fernández Vázquez, José Pedro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad Rey Juan Carlos
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/18912
Acceso en línea:https://www.mdpi.com/2077-0383/10/17/3854
https://hdl.handle.net/10612/18912
Access Level:acceso abierto
Palabra clave:Sanidad animal
SARS-CoV-2
Screening
Antigen
5312.07 Sanidad
32 Ciencias Médicas
3202 Epidemiología
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spelling Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 ScreeningMartín Sánchez, VicenteFernández Villa, TaniaCarvajal Urueña, Ana MaríaRivero Rodríguez, Ana MaríaReguero Celada, SofíaSánchez Antolín, GloriaFernández Vázquez, José PedroSanidad animalSARS-CoV-2ScreeningAntigen5312.07 Sanidad32 Ciencias Médicas3202 EpidemiologíaCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).[EN] This study evaluates a population‐based screening of asymptomatic people, using a rapid antigen diagnostic test (RADT), in areas of high transmission. To detect sources of SARS‐CoV‐2 infection, nasopharyngeal samples were taken and were tested using RADT. Confirmatory RT-qPCR tests were performed in both positive and negative cases. The internal validity of the RADT, the prevalence of infection, and the positive and negative predictive values (PPV and NPV) were estimated, based on the percentages of confirmed cases with 95% confidence interval.. Of the 157,920 people registered, 50,492 participated in the screening; 50,052 were negative, and 440 were positive on the RADT (0.87%). A total of 221 positive RADT samples were reanalysed using RT-qPCR and 214 were confirmed as positive (96.8%; 95% CI: 93.5–98.7%), while 657 out of 660 negative RADT samples were confirmed as RT‐qPCR negative (99.5%; 95% CI 98.7–99.9%). The sensitivity obtained was 65.1% (38.4–90.2%) and the specificity was 99.97% (99.94–99.99%). The prevalence of infection was 1.30% (0.95–2.13%). The PPVs were 95.4% (85.9–98.9%) and 97.9% (93.3–99.5%), respectively, while the NPVs were 99.7% (99.4–100%) and 99.2% (98.7–100%), respectively. The high specificity found allow us to report a high screening performance in asymptomatic patients, even in areas where the prevalence of infection was less than 2%.SIThis research received no external funding.Authors are grateful the collaboration of the Primary Care Management and all workers and volunteers who participated in the screenings.MDPISanidad AnimalFacultad de Veterinaria2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://www.mdpi.com/2077-0383/10/17/3854https://hdl.handle.net/10612/18912reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad Rey Juan CarlosIngléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/189122026-06-24T12:43:27Z
dc.title.none.fl_str_mv Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening
title Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening
spellingShingle Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening
Martín Sánchez, Vicente
Sanidad animal
SARS-CoV-2
Screening
Antigen
5312.07 Sanidad
32 Ciencias Médicas
3202 Epidemiología
title_short Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening
title_full Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening
title_fullStr Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening
title_full_unstemmed Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening
title_sort Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening
dc.creator.none.fl_str_mv Martín Sánchez, Vicente
Fernández Villa, Tania
Carvajal Urueña, Ana María
Rivero Rodríguez, Ana María
Reguero Celada, Sofía
Sánchez Antolín, Gloria
Fernández Vázquez, José Pedro
author Martín Sánchez, Vicente
author_facet Martín Sánchez, Vicente
Fernández Villa, Tania
Carvajal Urueña, Ana María
Rivero Rodríguez, Ana María
Reguero Celada, Sofía
Sánchez Antolín, Gloria
Fernández Vázquez, José Pedro
author_role author
author2 Fernández Villa, Tania
Carvajal Urueña, Ana María
Rivero Rodríguez, Ana María
Reguero Celada, Sofía
Sánchez Antolín, Gloria
Fernández Vázquez, José Pedro
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sanidad Animal
Facultad de Veterinaria
dc.subject.none.fl_str_mv Sanidad animal
SARS-CoV-2
Screening
Antigen
5312.07 Sanidad
32 Ciencias Médicas
3202 Epidemiología
topic Sanidad animal
SARS-CoV-2
Screening
Antigen
5312.07 Sanidad
32 Ciencias Médicas
3202 Epidemiología
description Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.mdpi.com/2077-0383/10/17/3854
https://hdl.handle.net/10612/18912
url https://www.mdpi.com/2077-0383/10/17/3854
https://hdl.handle.net/10612/18912
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Universidad Rey Juan Carlos
instname_str Universidad Rey Juan Carlos
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
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