Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics

Neuroinflammation is widely recognized as a significant hallmark of Alzheimer's disease (AD). To combat neuroinflammation, the inhibition of the soluble epoxide hydrolase (sEH) enzyme has been demonstrated crucial. Importantly, sEH inhibition could be related to other neuroprotective pathways d...

Descripción completa

Detalles Bibliográficos
Autores: Griñán-Ferré, Christian, Jarné-Ferrer, Júlia, Bellver-Sanchís, Aina, Codony, Sandra, Puigoriol-Illamola, Dolors, Sanfeliu, Coral, Oh, Yumin, Lee, Seulki, Vázquez, Santiago, Pallàs, Mercè
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/366068
Acceso en línea:http://hdl.handle.net/10261/366068
https://api.elsevier.com/content/abstract/scopus_id/85175455048
Access Level:acceso abierto
Palabra clave:5XFAD
endoplasmic reticulum stress
epoxide hydrolase
glia
neuroinflammation
id ES_5617c442b2b6f9b46cd4bbd737eb20bf
oai_identifier_str oai:digital.csic.es:10261/366068
network_acronym_str ES
network_name_str España
repository_id_str
spelling Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeuticsGriñán-Ferré, ChristianJarné-Ferrer, JúliaBellver-Sanchís, AinaCodony, SandraPuigoriol-Illamola, DolorsSanfeliu, CoralOh, YuminLee, SeulkiVázquez, SantiagoPallàs, Mercè5XFADendoplasmic reticulum stressepoxide hydrolaseglianeuroinflammationNeuroinflammation is widely recognized as a significant hallmark of Alzheimer's disease (AD). To combat neuroinflammation, the inhibition of the soluble epoxide hydrolase (sEH) enzyme has been demonstrated crucial. Importantly, sEH inhibition could be related to other neuroprotective pathways described in AD.This work was supported by Spanish Ministerio de Ciencia e Innovación (PID2019-106285/AEI/10.13039/501100011033; PDC2021-121096/AEI/10.13039/501100011033; María de Maeztu Unit of Excellence to Institute of Neurosciences, University of Barcelona, MDM-2017-0729) and 2021SGR357 (AGAUR, Catalonia). ABS acknowledges a FI SDUR (2021 FI-B0812) fellowship to AGAUR Catalonia.Peer reviewedJohn Wiley & SonsAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Ministerio de Ciencia e Innovación (España)Universidad de BarcelonaGeneralitat de CatalunyaPallàs, Mercè [0000-0003-3095-4254]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/366068https://api.elsevier.com/content/abstract/scopus_id/85175455048reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106285RB-C21info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-121096-C21info:eu-repo/grantAgreement/AEI//MDM-2017-0729info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106285RB-C22info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-121096-C22The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1111/cns.14511https://doi.org/10.1111/cns.14511Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3660682026-05-22T06:33:51Z
dc.title.none.fl_str_mv Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics
title Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics
spellingShingle Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics
Griñán-Ferré, Christian
5XFAD
endoplasmic reticulum stress
epoxide hydrolase
glia
neuroinflammation
title_short Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics
title_full Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics
title_fullStr Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics
title_full_unstemmed Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics
title_sort Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics
dc.creator.none.fl_str_mv Griñán-Ferré, Christian
Jarné-Ferrer, Júlia
Bellver-Sanchís, Aina
Codony, Sandra
Puigoriol-Illamola, Dolors
Sanfeliu, Coral
Oh, Yumin
Lee, Seulki
Vázquez, Santiago
Pallàs, Mercè
author Griñán-Ferré, Christian
author_facet Griñán-Ferré, Christian
Jarné-Ferrer, Júlia
Bellver-Sanchís, Aina
Codony, Sandra
Puigoriol-Illamola, Dolors
Sanfeliu, Coral
Oh, Yumin
Lee, Seulki
Vázquez, Santiago
Pallàs, Mercè
author_role author
author2 Jarné-Ferrer, Júlia
Bellver-Sanchís, Aina
Codony, Sandra
Puigoriol-Illamola, Dolors
Sanfeliu, Coral
Oh, Yumin
Lee, Seulki
Vázquez, Santiago
Pallàs, Mercè
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Ministerio de Ciencia e Innovación (España)
Universidad de Barcelona
Generalitat de Catalunya
Pallàs, Mercè [0000-0003-3095-4254]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv 5XFAD
endoplasmic reticulum stress
epoxide hydrolase
glia
neuroinflammation
topic 5XFAD
endoplasmic reticulum stress
epoxide hydrolase
glia
neuroinflammation
description Neuroinflammation is widely recognized as a significant hallmark of Alzheimer's disease (AD). To combat neuroinflammation, the inhibition of the soluble epoxide hydrolase (sEH) enzyme has been demonstrated crucial. Importantly, sEH inhibition could be related to other neuroprotective pathways described in AD.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/366068
https://api.elsevier.com/content/abstract/scopus_id/85175455048
url http://hdl.handle.net/10261/366068
https://api.elsevier.com/content/abstract/scopus_id/85175455048
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106285RB-C21
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-121096-C21
info:eu-repo/grantAgreement/AEI//MDM-2017-0729
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106285RB-C22
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-121096-C22
The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1111/cns.14511
https://doi.org/10.1111/cns.14511
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869408355030663168
score 15.811543

Similares en LA Referencia