Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics

Neuroinflammation is widely recognized as a significant hallmark of Alzheimer's disease (AD). To combat neuroinflammation, the inhibition of the soluble epoxide hydrolase (sEH) enzyme has been demonstrated crucial. Importantly, sEH inhibition could be related to other neuroprotective pathways d...

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Detalles Bibliográficos
Autores: Griñán-Ferré, Christian, Jarné-Ferrer, Júlia, Bellver-Sanchís, Aina, Codony, Sandra, Puigoriol-Illamola, Dolors, Sanfeliu, Coral, Oh, Yumin, Lee, Seulki, Vázquez, Santiago, Pallàs, Mercè
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/366068
Acceso en línea:http://hdl.handle.net/10261/366068
https://api.elsevier.com/content/abstract/scopus_id/85175455048
Access Level:acceso abierto
Palabra clave:5XFAD
endoplasmic reticulum stress
epoxide hydrolase
glia
neuroinflammation
Descripción
Sumario:Neuroinflammation is widely recognized as a significant hallmark of Alzheimer's disease (AD). To combat neuroinflammation, the inhibition of the soluble epoxide hydrolase (sEH) enzyme has been demonstrated crucial. Importantly, sEH inhibition could be related to other neuroprotective pathways described in AD.

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