Role of polycomb-like proteins in mouse embryonic stem cell differentiation
Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex formed by a core and the associated factors that are assembled and dynamically expressed in a cell t...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/690465 |
| Acceso en línea: | http://hdl.handle.net/10803/690465 |
| Access Level: | acceso embargado |
| Palabra clave: | Polycomb repressive complex 2 Mouse embryonic stem cells Chromatin Gene regulation Cell differentiation Complejo represor Polycomb 2 Células madre embrionarias de ratón Cromatina Regulación génica Diferenciación celular 576 |
| Sumario: | Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex formed by a core and the associated factors that are assembled and dynamically expressed in a cell type-specific manner. Although extensive studies have elucidated the role and composition of PRC2 in mouse embryonic stem cells (ESCs), little is known about its architecture and function during cellular differentiation. Polycomb-Like proteins (PCLs) are three mutually exclusive accessory factors of PRC2, crucial for chromatin recruitment of the complex. This thesis aims to characterise the role of PCLs during ESCs differentiation into mesodermal embryoid bodies (mesoEBs), pinpointing the essential MTF2 protein timeframe to address its molecular functions during this cellular fate transition. |
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