Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects

[Background] We have previously observed increased levels of inflammatory biomarkers and Th17 as well as Treg cells, but not other T-cell specific alterations, preceding immunodiscordance of successfully-treated HIV-infected subjects. Our hypothesis is that this could be related with potential alter...

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Autores: Rosado-Sánchez, Isaac, Pablo-Bernal, Rebeca de, Rull, Anna, González, Juan, Moreno, Santiago, Vinuesa García, David, Estrada Pérez, Vicente, Muñoz-Fernández, María Ángeles, Vidal, Francesc, Leal, Manuel, Pacheco, Yolanda M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/231319
Acceso en línea:http://hdl.handle.net/10261/231319
Access Level:acceso abierto
Palabra clave:HIV
Immunodiscordance
MDSC
Monocytes
Th17
Treg
CCR2
PDL-1
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spelling Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected SubjectsRosado-Sánchez, IsaacPablo-Bernal, Rebeca deRull, AnnaGonzález, JuanMoreno, SantiagoVinuesa García, DavidEstrada Pérez, VicenteMuñoz-Fernández, María ÁngelesVidal, FrancescLeal, ManuelPacheco, Yolanda M.HIVImmunodiscordanceMDSCMonocytesTh17TregCCR2PDL-1[Background] We have previously observed increased levels of inflammatory biomarkers and Th17 as well as Treg cells, but not other T-cell specific alterations, preceding immunodiscordance of successfully-treated HIV-infected subjects. Our hypothesis is that this could be related with potential alterations in myeloid-derived suppressor cells (MDSCs) and/or monocyte subsets.[Methods] We determined the frequencies of MDSCs and monocyte subsets and the expression of several functional markers (CCR2, β7-integrin, IDO, PDL1, CD11b) in HIV-infected subjects before treatment. We additionally analyzed follow-up samples after 24 months of suppressive cART in a subgroup of subjects. Bivariate regressions were performed, and correlations with soluble proinflammatory and bacterial translocation biomarkers, as well as with Th17/Treg ratio and anti-CMV titers were explored.[Results] Increased frequencies of MDSCs, but normal distribution of monocyte subsets, preceded immunodiscordance. The expression of several functional markers, such as CCR2, CD16, CD11b and PDL1, on MDSCs and monocyte subsets was altered in this scenario. MDSC and monocyte-related functional markers were associated with soluble biomarkers and T-cell parameters. Several of these cellular alterations were not restored after 24 months of suppressive cART.[Conclusion] An early immunosuppressive environment, characterized by the expansion of MDSCs and Tregs, precedes immunodiscordance and is related with a highly inflammatory status.This study was funded by grants from the Instituto de Salud Carlos III, Fondo de Investigación Sanitaria [FIS; PI16/00503, PI18/01216, PI19/01337; PI20/00326] and contratos para la intensificación de la actividad investigadora en el SNS [INT20/00031], co-funded by European Regional Development Fund/European Social Fund; “A way to make Europe”/”Investing in your future”, by the Programa de Suport als Grups de Recerca AGAUR (2017SGR948). The Spanish AIDS Research Network of Excellence also supported this study (RD16/0025/0019; RD16/0025/0006). YP was supported by the Consejería de Salud y Bienestar Social of Junta de Andalucía through the ‘‘Nicolás Monardes’’ programme [C-0013-2017]. AR is supported by IISPV through the project “2019/IISPV/05” (Boosting Young Talent), by GeSIDA through the “III Premio a Jóvenes Investigadores” and by ISCIII through the Miguel Servet Program “CP19/00146”.Frontiers MediaInstituto de Salud Carlos IIIEuropean CommissionAgència de Gestió d'Ajuts Universitaris i de RecercaRed Española de Investigación en SIDAJunta de AndalucíaInstitut d'Investigació Sanitària Pere VirgiliFundación SEIMC-GESIDAConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/231319reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://doi.org/10.3389/fimmu.2020.581307Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2313192026-05-22T06:33:51Z
dc.title.none.fl_str_mv Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects
title Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects
spellingShingle Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects
Rosado-Sánchez, Isaac
HIV
Immunodiscordance
MDSC
Monocytes
Th17
Treg
CCR2
PDL-1
title_short Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects
title_full Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects
title_fullStr Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects
title_full_unstemmed Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects
title_sort Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects
dc.creator.none.fl_str_mv Rosado-Sánchez, Isaac
Pablo-Bernal, Rebeca de
Rull, Anna
González, Juan
Moreno, Santiago
Vinuesa García, David
Estrada Pérez, Vicente
Muñoz-Fernández, María Ángeles
Vidal, Francesc
Leal, Manuel
Pacheco, Yolanda M.
author Rosado-Sánchez, Isaac
author_facet Rosado-Sánchez, Isaac
Pablo-Bernal, Rebeca de
Rull, Anna
González, Juan
Moreno, Santiago
Vinuesa García, David
Estrada Pérez, Vicente
Muñoz-Fernández, María Ángeles
Vidal, Francesc
Leal, Manuel
Pacheco, Yolanda M.
author_role author
author2 Pablo-Bernal, Rebeca de
Rull, Anna
González, Juan
Moreno, Santiago
Vinuesa García, David
Estrada Pérez, Vicente
Muñoz-Fernández, María Ángeles
Vidal, Francesc
Leal, Manuel
Pacheco, Yolanda M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Agència de Gestió d'Ajuts Universitaris i de Recerca
Red Española de Investigación en SIDA
Junta de Andalucía
Institut d'Investigació Sanitària Pere Virgili
Fundación SEIMC-GESIDA
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv HIV
Immunodiscordance
MDSC
Monocytes
Th17
Treg
CCR2
PDL-1
topic HIV
Immunodiscordance
MDSC
Monocytes
Th17
Treg
CCR2
PDL-1
description [Background] We have previously observed increased levels of inflammatory biomarkers and Th17 as well as Treg cells, but not other T-cell specific alterations, preceding immunodiscordance of successfully-treated HIV-infected subjects. Our hypothesis is that this could be related with potential alterations in myeloid-derived suppressor cells (MDSCs) and/or monocyte subsets.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/231319
url http://hdl.handle.net/10261/231319
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://doi.org/10.3389/fimmu.2020.581307
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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