Increased Frequencies of Myeloid-Derived Suppressor Cells Precede Immunodiscordance in HIV-Infected Subjects

[Background] We have previously observed increased levels of inflammatory biomarkers and Th17 as well as Treg cells, but not other T-cell specific alterations, preceding immunodiscordance of successfully-treated HIV-infected subjects. Our hypothesis is that this could be related with potential alter...

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Detalles Bibliográficos
Autores: Rosado-Sánchez, Isaac, Pablo-Bernal, Rebeca de, Rull, Anna, González, Juan, Moreno, Santiago, Vinuesa García, David, Estrada Pérez, Vicente, Muñoz-Fernández, María Ángeles, Vidal, Francesc, Leal, Manuel, Pacheco, Yolanda M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/231319
Acceso en línea:http://hdl.handle.net/10261/231319
Access Level:acceso abierto
Palabra clave:HIV
Immunodiscordance
MDSC
Monocytes
Th17
Treg
CCR2
PDL-1
Descripción
Sumario:[Background] We have previously observed increased levels of inflammatory biomarkers and Th17 as well as Treg cells, but not other T-cell specific alterations, preceding immunodiscordance of successfully-treated HIV-infected subjects. Our hypothesis is that this could be related with potential alterations in myeloid-derived suppressor cells (MDSCs) and/or monocyte subsets.

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