Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies

Background: The control of latent tuberculosis infection (LTBI) encompasses multiple stages. The objective was to calculate the losses in the LTBI care cascade for pulmonary TB contacts in Catalonia (Spain). Methods: The LTBI care cascade was studied for pulmonary TB contacts reported from 1 January...

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Autores: Godoy, Sofía, Parrón, Ignacio, Millet, Joan Pau, Caylà, Joan A., Follia, Núria, Carol, Monica, Orcau, Angels, Alsedà Graells, Miquel, Toledo, Diana, Ferrús, Gloria, Plans-Rubio, Pedro, Barrabeig i Fabregat, Irene, Clotet, Laura, Domínguez García, Àngela, Godoy i García, Pere
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/465729
Acceso en línea:https://doi.org/10.3390/pathogens12121403
https://hdl.handle.net/10459.1/465729
Access Level:acceso abierto
Palabra clave:Tuberculosis
Latent tuberculosis infection
Contact tracing
Epidemiology
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spelling Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact StudiesGodoy, SofíaParrón, IgnacioMillet, Joan PauCaylà, Joan A.Follia, NúriaCarol, MonicaOrcau, AngelsAlsedà Graells, MiquelToledo, DianaFerrús, GloriaPlans-Rubio, PedroBarrabeig i Fabregat, IreneClotet, LauraDomínguez García, ÀngelaGodoy i García, PereTuberculosisLatent tuberculosis infectionContact tracingEpidemiologyBackground: The control of latent tuberculosis infection (LTBI) encompasses multiple stages. The objective was to calculate the losses in the LTBI care cascade for pulmonary TB contacts in Catalonia (Spain). Methods: The LTBI care cascade was studied for pulmonary TB contacts reported from 1 January 2019 to 30 June 2021, considering three dependent variables: non-performance of testing; non-receipt of a treatment prescription; and non-adherence to treatment. Variables associated with the cascade were analysed using adjusted OR (aOR) and 95% confidence intervals (CI). Results: Identified from 847 cases of pulmonary TB were 7087 contacts, of whom 6537 (92.2%) could be screened for LTBI. LTBI prevalence was 25.5% (1670/6537); 69.4% of persons with LTBI (1159/1670) received a treatment prescription and 71.3% (827/1159) completed it. Treatment prescription was associated with age ≥65 years (aOR = 0.3; 95%CI: 0.2–0.6) and a daily exposure of ≥6 h to the TB index case (aOR = 3.6; 95%CI: 2.6–5.0). Treatment adherence was lower in men (aOR = 0.7; 95%CI: 0.5–1.0) and immigrants (aOR = 0.7; 95%CI: 0.5–0.9). Conclusions: Under 50% of contacts make it to the end of the LTBI cascade. Losses need to be reduced through education of both healthcare providers and patients and through treatment monitoring. The greater involvement of primary care physicians could help in monitoring and controling LTBI.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/pathogens12121403https://hdl.handle.net/10459.1/465729reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/pathogens12121403Pathogens, 2023, vol. 12, núm. 12cc-by (c) authors, 2023Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/4657292026-05-29T05:05:01Z
dc.title.none.fl_str_mv Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies
title Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies
spellingShingle Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies
Godoy, Sofía
Tuberculosis
Latent tuberculosis infection
Contact tracing
Epidemiology
title_short Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies
title_full Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies
title_fullStr Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies
title_full_unstemmed Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies
title_sort Losses in the Care Cascade for Latent Tuberculosis Infection in the Tracing Contact Studies
dc.creator.none.fl_str_mv Godoy, Sofía
Parrón, Ignacio
Millet, Joan Pau
Caylà, Joan A.
Follia, Núria
Carol, Monica
Orcau, Angels
Alsedà Graells, Miquel
Toledo, Diana
Ferrús, Gloria
Plans-Rubio, Pedro
Barrabeig i Fabregat, Irene
Clotet, Laura
Domínguez García, Àngela
Godoy i García, Pere
author Godoy, Sofía
author_facet Godoy, Sofía
Parrón, Ignacio
Millet, Joan Pau
Caylà, Joan A.
Follia, Núria
Carol, Monica
Orcau, Angels
Alsedà Graells, Miquel
Toledo, Diana
Ferrús, Gloria
Plans-Rubio, Pedro
Barrabeig i Fabregat, Irene
Clotet, Laura
Domínguez García, Àngela
Godoy i García, Pere
author_role author
author2 Parrón, Ignacio
Millet, Joan Pau
Caylà, Joan A.
Follia, Núria
Carol, Monica
Orcau, Angels
Alsedà Graells, Miquel
Toledo, Diana
Ferrús, Gloria
Plans-Rubio, Pedro
Barrabeig i Fabregat, Irene
Clotet, Laura
Domínguez García, Àngela
Godoy i García, Pere
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Tuberculosis
Latent tuberculosis infection
Contact tracing
Epidemiology
topic Tuberculosis
Latent tuberculosis infection
Contact tracing
Epidemiology
description Background: The control of latent tuberculosis infection (LTBI) encompasses multiple stages. The objective was to calculate the losses in the LTBI care cascade for pulmonary TB contacts in Catalonia (Spain). Methods: The LTBI care cascade was studied for pulmonary TB contacts reported from 1 January 2019 to 30 June 2021, considering three dependent variables: non-performance of testing; non-receipt of a treatment prescription; and non-adherence to treatment. Variables associated with the cascade were analysed using adjusted OR (aOR) and 95% confidence intervals (CI). Results: Identified from 847 cases of pulmonary TB were 7087 contacts, of whom 6537 (92.2%) could be screened for LTBI. LTBI prevalence was 25.5% (1670/6537); 69.4% of persons with LTBI (1159/1670) received a treatment prescription and 71.3% (827/1159) completed it. Treatment prescription was associated with age ≥65 years (aOR = 0.3; 95%CI: 0.2–0.6) and a daily exposure of ≥6 h to the TB index case (aOR = 3.6; 95%CI: 2.6–5.0). Treatment adherence was lower in men (aOR = 0.7; 95%CI: 0.5–1.0) and immigrants (aOR = 0.7; 95%CI: 0.5–0.9). Conclusions: Under 50% of contacts make it to the end of the LTBI cascade. Losses need to be reduced through education of both healthcare providers and patients and through treatment monitoring. The greater involvement of primary care physicians could help in monitoring and controling LTBI.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/pathogens12121403
https://hdl.handle.net/10459.1/465729
url https://doi.org/10.3390/pathogens12121403
https://hdl.handle.net/10459.1/465729
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/pathogens12121403
Pathogens, 2023, vol. 12, núm. 12
dc.rights.none.fl_str_mv cc-by (c) authors, 2023
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) authors, 2023
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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