Métodos multivariantes aplicados a la efectividad de los disolventes en la industria farmacéutica
Introduction: Solvents are chemical agents used in the pharmaceutical industry. Their importance is that their presence can accelerate or delay the reaction of a drug up to a million times. Objective: The present investigation analyzes the different types of solvents in order to evaluate the existen...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universitat Oberta de Catalunya (UOC) |
| Repositorio: | O2, repositorio institucional de la UOC |
| OAI Identifier: | oai:openaccess.uoc.edu:10609/101909 |
| Acceso en línea: | https://hdl.handle.net/10609/101909 |
| Access Level: | acceso abierto |
| Palabra clave: | Multivariant analysis Solvents Principal components Clustering Classification Análisis multivariante Disolventes Componentes principales Clasificación Pharmaceutical industry Dissolvents Indústria farmacèutica Industria farmacéutica |
| Sumario: | Introduction: Solvents are chemical agents used in the pharmaceutical industry. Their importance is that their presence can accelerate or delay the reaction of a drug up to a million times. Objective: The present investigation analyzes the different types of solvents in order to evaluate the existence of groups in which patterns related to the effectiveness of the mentioned solvents in medicine production can be identified. Methodology: The study is comprised of 4 phases: 1) Principal component analysis; 2) Cluster analysis; 3) Discriminant analysis; 4) Interpretation of results and conclusions. Results: Three clusters, categorized as supercritical, microspherical and biodegradable, were identified. The Hotelling T test yields a p-value of 0, evidencing the difference between groups. The quadratic discriminant yields a precision of a 96% for the classification of solvents. Conclusions: The multivariate analysis allows modeling the effectiveness of solvents in the pharmaceutical industry. Hence, generating an objective decision methodology for the classification of solvents according to an effectiveness approach. |
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