Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals

Chondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical indu...

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Detalles Bibliográficos
Autores: Benito-Arenas, Raúl, Zárate, Sandra G., Revuelta, Julia, Bastida, Agatha
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/180704
Acceso en línea:http://hdl.handle.net/10261/180704
Access Level:acceso abierto
Palabra clave:Iyases
Chondroitin sulfates
Glycosaminoglycan
Polysaccharides
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spelling Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New PharmaceuticalsBenito-Arenas, RaúlZárate, Sandra G.Revuelta, JuliaBastida, AgathaIyasesChondroitin sulfatesGlycosaminoglycanPolysaccharidesChondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) lyases have been widely investigated as tools for the development of new pharmaceuticals based on these polysaccharides. This review focuses on the major breakthrough represented by chondroitin sulfate-degrading enzymes and their structures and mechanisms of function in addition to their major applications.The authors thank the Ministerio de Economía y Competitividad (grants MAT2015- 65184-C2-2-R and CTQ2016-79255-P) for their supportWe acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI)Multidisciplinary Digital Publishing InstituteConsejo Superior de Investigaciones Científicas (España)Ministerio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/180704reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-65184-C2-2-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-79255-Phttp://dx.doi.org/10.3390/catal9040322Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1807042026-05-22T06:33:51Z
dc.title.none.fl_str_mv Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
title Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
spellingShingle Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
Benito-Arenas, Raúl
Iyases
Chondroitin sulfates
Glycosaminoglycan
Polysaccharides
title_short Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
title_full Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
title_fullStr Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
title_full_unstemmed Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
title_sort Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
dc.creator.none.fl_str_mv Benito-Arenas, Raúl
Zárate, Sandra G.
Revuelta, Julia
Bastida, Agatha
author Benito-Arenas, Raúl
author_facet Benito-Arenas, Raúl
Zárate, Sandra G.
Revuelta, Julia
Bastida, Agatha
author_role author
author2 Zárate, Sandra G.
Revuelta, Julia
Bastida, Agatha
author2_role author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas (España)
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Iyases
Chondroitin sulfates
Glycosaminoglycan
Polysaccharides
topic Iyases
Chondroitin sulfates
Glycosaminoglycan
Polysaccharides
description Chondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) lyases have been widely investigated as tools for the development of new pharmaceuticals based on these polysaccharides. This review focuses on the major breakthrough represented by chondroitin sulfate-degrading enzymes and their structures and mechanisms of function in addition to their major applications.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/180704
url http://hdl.handle.net/10261/180704
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MAT2015-65184-C2-2-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-79255-P
http://dx.doi.org/10.3390/catal9040322
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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