The interplay between infection risk factors of SARS-CoV-2 and mortality

Covid-19 pandemic has particularly affected older people living in Long-term Care settings in terms of infection and mortality. We carried out a cross-sectional analysis within a cohort of Long-term care nursing home residents between March first and June thirty, 2020, who were ≥ 65 years old and on...

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Autores: Soldevila Langa, Laura|||0000-0002-3324-0225, Prat Gil, Nuria|||0000-0003-1689-9017, Mas Bergas, Miquel Àngel|||0000-0002-8756-3783, Massot Mesquida, Mireia|||0000-0003-3649-5167, Miralles Basseda, Ramon|||0000-0002-7770-7819, Bonet Simó, Josep Maria|||0000-0002-7981-5880, Isnard, Mar|||0000-0001-6297-8520, Expósito-Izquierdo, Marta, Garcia-Sanchez, Irene, Rodoreda-Noguerola, Sara|||0000-0003-1521-3757, Moreno, Nemesio|||0000-0002-1617-9549, Badia, Esther, López, Genís, Sevilla, Javier, Estrada Cuxart, Oriol|||0000-0003-1414-5000, Vallès, Xavier|||0000-0002-4445-1490
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:256060
Acceso en línea:https://ddd.uab.cat/record/256060
https://dx.doi.org/urn:doi:10.1186/s12877-022-02779-0
Access Level:acceso abierto
Palabra clave:Long-term care nursing homes
SARS-CoV-2
Epidemiology
Mortality
Covid-19
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spelling The interplay between infection risk factors of SARS-CoV-2 and mortalitya cross-sectional study from a cohort of long-term care nursing home residentsSoldevila Langa, Laura|||0000-0002-3324-0225Prat Gil, Nuria|||0000-0003-1689-9017Mas Bergas, Miquel Àngel|||0000-0002-8756-3783Massot Mesquida, Mireia|||0000-0003-3649-5167Miralles Basseda, Ramon|||0000-0002-7770-7819Bonet Simó, Josep Maria|||0000-0002-7981-5880Isnard, Mar|||0000-0001-6297-8520Expósito-Izquierdo, MartaGarcia-Sanchez, IreneRodoreda-Noguerola, Sara|||0000-0003-1521-3757Moreno, Nemesio|||0000-0002-1617-9549Badia, EstherLópez, GenísSevilla, JavierEstrada Cuxart, Oriol|||0000-0003-1414-5000Vallès, Xavier|||0000-0002-4445-1490Long-term care nursing homesSARS-CoV-2EpidemiologyMortalityCovid-19Covid-19 pandemic has particularly affected older people living in Long-term Care settings in terms of infection and mortality. We carried out a cross-sectional analysis within a cohort of Long-term care nursing home residents between March first and June thirty, 2020, who were ≥ 65 years old and on whom at least one PCR test was performed. Socio-demographic, comorbidities, and clinical data were recorded. Facility size and community incidence of SARS-CoV-2 were also considered. The outcomes of interest were infection (PCR positive) and death. A total of 8021 residents were included from 168 facilities. Mean age was 86.4 years (SD = 7.4). Women represented 74.1%. SARS-CoV-2 infection was detected in 27.7% of participants, and the overall case fatality rate was 11.3% (24.9% among those with a positive PCR test). Epidemiological factors related to risk of infection were larger facility size (pooled aOR 1.73; P <.001), higher community incidence (pooled aOR 1.67, P =.04), leading to a higher risk than the clinical factor of low level of functional dependence (aOR 1.22, P =.03). Epidemiological risk factors associated with mortality were male gender (aOR 1.75; P <.001), age (pooled aOR 1.16; P <.001), and higher community incidence (pooled aOR 1.19, P = < 0.001) whereas clinical factors were low level of functional dependence (aOR 2.42, P <.001), Complex Chronic Condition (aOR 1.29, P <.001) and dementia (aOR 1.33, P <0.001). There was evidence of clustering for facility and health area when considering the risk of infection and mortality (P <.001). Our results suggest a complex interplay between structural and individual factors regarding Covid-19 infection and its impact on mortality in nursing-home residents. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/256060https://dx.doi.org/urn:doi:10.1186/s12877-022-02779-0reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2560602026-06-06T12:50:31Z
dc.title.none.fl_str_mv The interplay between infection risk factors of SARS-CoV-2 and mortality
a cross-sectional study from a cohort of long-term care nursing home residents
title The interplay between infection risk factors of SARS-CoV-2 and mortality
spellingShingle The interplay between infection risk factors of SARS-CoV-2 and mortality
Soldevila Langa, Laura|||0000-0002-3324-0225
Long-term care nursing homes
SARS-CoV-2
Epidemiology
Mortality
Covid-19
title_short The interplay between infection risk factors of SARS-CoV-2 and mortality
title_full The interplay between infection risk factors of SARS-CoV-2 and mortality
title_fullStr The interplay between infection risk factors of SARS-CoV-2 and mortality
title_full_unstemmed The interplay between infection risk factors of SARS-CoV-2 and mortality
title_sort The interplay between infection risk factors of SARS-CoV-2 and mortality
dc.creator.none.fl_str_mv Soldevila Langa, Laura|||0000-0002-3324-0225
Prat Gil, Nuria|||0000-0003-1689-9017
Mas Bergas, Miquel Àngel|||0000-0002-8756-3783
Massot Mesquida, Mireia|||0000-0003-3649-5167
Miralles Basseda, Ramon|||0000-0002-7770-7819
Bonet Simó, Josep Maria|||0000-0002-7981-5880
Isnard, Mar|||0000-0001-6297-8520
Expósito-Izquierdo, Marta
Garcia-Sanchez, Irene
Rodoreda-Noguerola, Sara|||0000-0003-1521-3757
Moreno, Nemesio|||0000-0002-1617-9549
Badia, Esther
López, Genís
Sevilla, Javier
Estrada Cuxart, Oriol|||0000-0003-1414-5000
Vallès, Xavier|||0000-0002-4445-1490
author Soldevila Langa, Laura|||0000-0002-3324-0225
author_facet Soldevila Langa, Laura|||0000-0002-3324-0225
Prat Gil, Nuria|||0000-0003-1689-9017
Mas Bergas, Miquel Àngel|||0000-0002-8756-3783
Massot Mesquida, Mireia|||0000-0003-3649-5167
Miralles Basseda, Ramon|||0000-0002-7770-7819
Bonet Simó, Josep Maria|||0000-0002-7981-5880
Isnard, Mar|||0000-0001-6297-8520
Expósito-Izquierdo, Marta
Garcia-Sanchez, Irene
Rodoreda-Noguerola, Sara|||0000-0003-1521-3757
Moreno, Nemesio|||0000-0002-1617-9549
Badia, Esther
López, Genís
Sevilla, Javier
Estrada Cuxart, Oriol|||0000-0003-1414-5000
Vallès, Xavier|||0000-0002-4445-1490
author_role author
author2 Prat Gil, Nuria|||0000-0003-1689-9017
Mas Bergas, Miquel Àngel|||0000-0002-8756-3783
Massot Mesquida, Mireia|||0000-0003-3649-5167
Miralles Basseda, Ramon|||0000-0002-7770-7819
Bonet Simó, Josep Maria|||0000-0002-7981-5880
Isnard, Mar|||0000-0001-6297-8520
Expósito-Izquierdo, Marta
Garcia-Sanchez, Irene
Rodoreda-Noguerola, Sara|||0000-0003-1521-3757
Moreno, Nemesio|||0000-0002-1617-9549
Badia, Esther
López, Genís
Sevilla, Javier
Estrada Cuxart, Oriol|||0000-0003-1414-5000
Vallès, Xavier|||0000-0002-4445-1490
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Long-term care nursing homes
SARS-CoV-2
Epidemiology
Mortality
Covid-19
topic Long-term care nursing homes
SARS-CoV-2
Epidemiology
Mortality
Covid-19
description Covid-19 pandemic has particularly affected older people living in Long-term Care settings in terms of infection and mortality. We carried out a cross-sectional analysis within a cohort of Long-term care nursing home residents between March first and June thirty, 2020, who were ≥ 65 years old and on whom at least one PCR test was performed. Socio-demographic, comorbidities, and clinical data were recorded. Facility size and community incidence of SARS-CoV-2 were also considered. The outcomes of interest were infection (PCR positive) and death. A total of 8021 residents were included from 168 facilities. Mean age was 86.4 years (SD = 7.4). Women represented 74.1%. SARS-CoV-2 infection was detected in 27.7% of participants, and the overall case fatality rate was 11.3% (24.9% among those with a positive PCR test). Epidemiological factors related to risk of infection were larger facility size (pooled aOR 1.73; P <.001), higher community incidence (pooled aOR 1.67, P =.04), leading to a higher risk than the clinical factor of low level of functional dependence (aOR 1.22, P =.03). Epidemiological risk factors associated with mortality were male gender (aOR 1.75; P <.001), age (pooled aOR 1.16; P <.001), and higher community incidence (pooled aOR 1.19, P = < 0.001) whereas clinical factors were low level of functional dependence (aOR 2.42, P <.001), Complex Chronic Condition (aOR 1.29, P <.001) and dementia (aOR 1.33, P <0.001). There was evidence of clustering for facility and health area when considering the risk of infection and mortality (P <.001). Our results suggest a complex interplay between structural and individual factors regarding Covid-19 infection and its impact on mortality in nursing-home residents.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/256060
https://dx.doi.org/urn:doi:10.1186/s12877-022-02779-0
url https://ddd.uab.cat/record/256060
https://dx.doi.org/urn:doi:10.1186/s12877-022-02779-0
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
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