The interplay between infection risk factors of SARS-CoV-2 and mortality

Covid-19 pandemic has particularly affected older people living in Long-term Care settings in terms of infection and mortality. We carried out a cross-sectional analysis within a cohort of Long-term care nursing home residents between March first and June thirty, 2020, who were ≥ 65 years old and on...

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Detalles Bibliográficos
Autores: Soldevila Langa, Laura|||0000-0002-3324-0225, Prat Gil, Nuria|||0000-0003-1689-9017, Mas Bergas, Miquel Àngel|||0000-0002-8756-3783, Massot Mesquida, Mireia|||0000-0003-3649-5167, Miralles Basseda, Ramon|||0000-0002-7770-7819, Bonet Simó, Josep Maria|||0000-0002-7981-5880, Isnard, Mar|||0000-0001-6297-8520, Expósito-Izquierdo, Marta, Garcia-Sanchez, Irene, Rodoreda-Noguerola, Sara|||0000-0003-1521-3757, Moreno, Nemesio|||0000-0002-1617-9549, Badia, Esther, López, Genís, Sevilla, Javier, Estrada Cuxart, Oriol|||0000-0003-1414-5000, Vallès, Xavier|||0000-0002-4445-1490
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:256060
Acceso en línea:https://ddd.uab.cat/record/256060
https://dx.doi.org/urn:doi:10.1186/s12877-022-02779-0
Access Level:acceso abierto
Palabra clave:Long-term care nursing homes
SARS-CoV-2
Epidemiology
Mortality
Covid-19
Descripción
Sumario:Covid-19 pandemic has particularly affected older people living in Long-term Care settings in terms of infection and mortality. We carried out a cross-sectional analysis within a cohort of Long-term care nursing home residents between March first and June thirty, 2020, who were ≥ 65 years old and on whom at least one PCR test was performed. Socio-demographic, comorbidities, and clinical data were recorded. Facility size and community incidence of SARS-CoV-2 were also considered. The outcomes of interest were infection (PCR positive) and death. A total of 8021 residents were included from 168 facilities. Mean age was 86.4 years (SD = 7.4). Women represented 74.1%. SARS-CoV-2 infection was detected in 27.7% of participants, and the overall case fatality rate was 11.3% (24.9% among those with a positive PCR test). Epidemiological factors related to risk of infection were larger facility size (pooled aOR 1.73; P <.001), higher community incidence (pooled aOR 1.67, P =.04), leading to a higher risk than the clinical factor of low level of functional dependence (aOR 1.22, P =.03). Epidemiological risk factors associated with mortality were male gender (aOR 1.75; P <.001), age (pooled aOR 1.16; P <.001), and higher community incidence (pooled aOR 1.19, P = < 0.001) whereas clinical factors were low level of functional dependence (aOR 2.42, P <.001), Complex Chronic Condition (aOR 1.29, P <.001) and dementia (aOR 1.33, P <0.001). There was evidence of clustering for facility and health area when considering the risk of infection and mortality (P <.001). Our results suggest a complex interplay between structural and individual factors regarding Covid-19 infection and its impact on mortality in nursing-home residents.

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