Photosensitizing proteins for antibacterial photodynamic inactivation

We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their tendency to aggregate often impair their photophysics, thus resulting in lower bioavailability of th...

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Detalles Bibliográficos
Autores: Nonell, Santi, Hally, Cormac, Delcanale, Pietro, Viappiani, Cristiano, Abbruzzetti, Stefania
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/1121
Acceso en línea:http://hdl.handle.net/20.500.14342/1121
https://doi.org/10.1002/tbio.201900031
Access Level:acceso abierto
Palabra clave:Fotosensibilització (Biologia)
Photodynamic effect
Singlet oxygen
Drug delivery
Protein carrier
Fluorescence
577
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spelling Photosensitizing proteins for antibacterial photodynamic inactivationNonell, SantiHally, CormacDelcanale, PietroViappiani, CristianoAbbruzzetti, StefaniaFotosensibilització (Biologia)Photodynamic effectSinglet oxygenDrug deliveryProtein carrierFluorescence577We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their tendency to aggregate often impair their photophysics, thus resulting in lower bioavailability of the compounds. Taking advantage of the spontaneous interaction between water soluble proteins endowed with hydrophobic cavities and the otherwise insoluble photosensitizing compounds, it is possible to obtain efficient delivery systems to be applied inaPDT. These self‐assembled structures are endowed with good photosensitizing and fluorescence emission properties (comparable to those of monomerized photosensitizers) with high biocompatibility and warrant good bioavailability of the photoactive drug. The proteins used so far comprise serum albumins, β‐lactoglobulin, and apomyoglobin, while photosensitizers considered up to now have been hypericin, curcumin, Zn‐protoporphyrin IX, and Zn‐phthalocyanine. Furthermore, mutants of fluorescent proteins derived from GFP‐like systems or from flavin binding proteins complete the array of available photosensitizing proteins for aPDT.Wiley-VCH VerlagUniversitat Ramon Llull. IQS2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.http://hdl.handle.net/20.500.14342/1121https://doi.org/10.1002/tbio.201900031reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésTranslational Biophotonics. Vol.2, n.1-2 (2020) e201900031info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2013-48767-C3-1-Rinfo:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-1-Rinfo:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2017 FI_B00617info:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2018 FI_B1 00174info:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2019 FI_B2 00167Attribution 4.0 International© L'autor/ahttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/11212026-05-29T05:05:01Z
dc.title.none.fl_str_mv Photosensitizing proteins for antibacterial photodynamic inactivation
title Photosensitizing proteins for antibacterial photodynamic inactivation
spellingShingle Photosensitizing proteins for antibacterial photodynamic inactivation
Nonell, Santi
Fotosensibilització (Biologia)
Photodynamic effect
Singlet oxygen
Drug delivery
Protein carrier
Fluorescence
577
title_short Photosensitizing proteins for antibacterial photodynamic inactivation
title_full Photosensitizing proteins for antibacterial photodynamic inactivation
title_fullStr Photosensitizing proteins for antibacterial photodynamic inactivation
title_full_unstemmed Photosensitizing proteins for antibacterial photodynamic inactivation
title_sort Photosensitizing proteins for antibacterial photodynamic inactivation
dc.creator.none.fl_str_mv Nonell, Santi
Hally, Cormac
Delcanale, Pietro
Viappiani, Cristiano
Abbruzzetti, Stefania
author Nonell, Santi
author_facet Nonell, Santi
Hally, Cormac
Delcanale, Pietro
Viappiani, Cristiano
Abbruzzetti, Stefania
author_role author
author2 Hally, Cormac
Delcanale, Pietro
Viappiani, Cristiano
Abbruzzetti, Stefania
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv Fotosensibilització (Biologia)
Photodynamic effect
Singlet oxygen
Drug delivery
Protein carrier
Fluorescence
577
topic Fotosensibilització (Biologia)
Photodynamic effect
Singlet oxygen
Drug delivery
Protein carrier
Fluorescence
577
description We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their tendency to aggregate often impair their photophysics, thus resulting in lower bioavailability of the compounds. Taking advantage of the spontaneous interaction between water soluble proteins endowed with hydrophobic cavities and the otherwise insoluble photosensitizing compounds, it is possible to obtain efficient delivery systems to be applied inaPDT. These self‐assembled structures are endowed with good photosensitizing and fluorescence emission properties (comparable to those of monomerized photosensitizers) with high biocompatibility and warrant good bioavailability of the photoactive drug. The proteins used so far comprise serum albumins, β‐lactoglobulin, and apomyoglobin, while photosensitizers considered up to now have been hypericin, curcumin, Zn‐protoporphyrin IX, and Zn‐phthalocyanine. Furthermore, mutants of fluorescent proteins derived from GFP‐like systems or from flavin binding proteins complete the array of available photosensitizing proteins for aPDT.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/1121
https://doi.org/10.1002/tbio.201900031
url http://hdl.handle.net/20.500.14342/1121
https://doi.org/10.1002/tbio.201900031
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Translational Biophotonics. Vol.2, n.1-2 (2020) e201900031
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2013-48767-C3-1-R
info:eu-repo/grantAgreement/MINECO/PN I+D/CTQ2016-78454-C2-1-R
info:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2017 FI_B00617
info:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2018 FI_B1 00174
info:eu-repo/grantAgreement/SUR del DEC i FSE/FI/2019 FI_B2 00167
dc.rights.none.fl_str_mv Attribution 4.0 International
© L'autor/a
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
© L'autor/a
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
dc.publisher.none.fl_str_mv Wiley-VCH Verlag
publisher.none.fl_str_mv Wiley-VCH Verlag
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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