Photosensitizing proteins for antibacterial photodynamic inactivation
We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their tendency to aggregate often impair their photophysics, thus resulting in lower bioavailability of th...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:20.500.14342/1121 |
| Acceso en línea: | http://hdl.handle.net/20.500.14342/1121 https://doi.org/10.1002/tbio.201900031 |
| Access Level: | acceso abierto |
| Palabra clave: | Fotosensibilització (Biologia) Photodynamic effect Singlet oxygen Drug delivery Protein carrier Fluorescence 577 |
| Sumario: | We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their tendency to aggregate often impair their photophysics, thus resulting in lower bioavailability of the compounds. Taking advantage of the spontaneous interaction between water soluble proteins endowed with hydrophobic cavities and the otherwise insoluble photosensitizing compounds, it is possible to obtain efficient delivery systems to be applied inaPDT. These self‐assembled structures are endowed with good photosensitizing and fluorescence emission properties (comparable to those of monomerized photosensitizers) with high biocompatibility and warrant good bioavailability of the photoactive drug. The proteins used so far comprise serum albumins, β‐lactoglobulin, and apomyoglobin, while photosensitizers considered up to now have been hypericin, curcumin, Zn‐protoporphyrin IX, and Zn‐phthalocyanine. Furthermore, mutants of fluorescent proteins derived from GFP‐like systems or from flavin binding proteins complete the array of available photosensitizing proteins for aPDT. |
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