Biomarkers for Psychosis
This umbrella review aims to comprehensively synthesize the evidence of association between peripheral, electrophysiological, neuroimaging, neuropathological, and other biomarkers and diagnosis of psychotic disorders. We selected systematic reviews and meta-analyses of observational studies on diagn...
| Autores: | , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:307669 |
| Acceso en línea: | https://ddd.uab.cat/record/307669 https://dx.doi.org/urn:doi:10.1093/schizbullopen/sgae018 |
| Access Level: | acceso abierto |
| Palabra clave: | Schizophrenia Psychotic disorders Peripheral biomarkers Electrophysiological biomarkers Neuroimaging biomarkers Neuropathological biomarkers |
| id |
ES_5149d8af70a9e2baa8ef8392e5fc4fdc |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:307669 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Biomarkers for PsychosisAre We There Yet? Umbrella Review of 1478 BiomarkersFuentes-Claramonte, Paola|||0000-0002-1428-7976Estradé, Andrés|||0000-0001-6871-5932Solanes, Aleix|||0000-0002-2491-200XRamella-Cravaro, ValentinaGarcia-Leon, Maria AngelesDiego-Adeliño, Javier de|||0000-0001-9708-2441Molins, ConradFung, EricValentí, MarcAnmella, Gerard|||0000-0002-6798-4054Pomarol-Clotet, Edith|||0000-0002-8159-8563Oliver, Dominic|||0000-0002-8920-3407Vieta, Eduard|||0000-0002-0548-0053Radua, Joaquim|||0000-0003-1240-5438Fusar-Poli, Paolo|||0000-0003-3582-6788SchizophreniaPsychotic disordersPeripheral biomarkersElectrophysiological biomarkersNeuroimaging biomarkersNeuropathological biomarkersThis umbrella review aims to comprehensively synthesize the evidence of association between peripheral, electrophysiological, neuroimaging, neuropathological, and other biomarkers and diagnosis of psychotic disorders. We selected systematic reviews and meta-analyses of observational studies on diagnostic biomarkers for psychotic disorders, published until February 1, 2018. Data extraction was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Evidence of association between biomarkers and psychotic disorders was classified as convincing, highly suggestive, suggestive, weak, or non-significant, using a standardized classification. Quality analyses used the Assessment of Multiple Systematic Reviews (AMSTAR) tool. The umbrella review included 110 meta-analyses or systematic reviews corresponding to 3892 individual studies, 1478 biomarkers, and 392 210 participants. No factor showed a convincing level of evidence. Highly suggestive evidence was observed for transglutaminase autoantibodies levels (odds ratio [OR] = 7.32; 95% CI: 3.36, 15.94), mismatch negativity in auditory event-related potentials (standardized mean difference [SMD] = 0.73; 95% CI: 0.5, 0.96), P300 component latency (SMD = -0.6; 95% CI: -0.83, -0.38), ventricle-brain ratio (SMD = 0.61; 95% CI: 0.5, 0.71), and minor physical anomalies (SMD = 0.99; 95% CI: 0.64, 1.34). Suggestive evidence was observed for folate, malondialdehyde, brain-derived neurotrophic factor, homocysteine, P50 sensory gating (P50 S2/S1 ratio), frontal N -acetyl-aspartate, and high-frequency heart rate variability. Among the remaining biomarkers, weak evidence was found for 626 and a non-significant association for 833 factors. While several biomarkers present highly suggestive or suggestive evidence of association with psychotic disorders, methodological biases, and underpowered studies call for future higher-quality research. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/307669https://dx.doi.org/urn:doi:10.1093/schizbullopen/sgae018reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01475Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-01271"la Caixa" Foundation https://doi.org/10.13039/100010434 100010434Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00394Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00261Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01128open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3076692026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Biomarkers for Psychosis Are We There Yet? Umbrella Review of 1478 Biomarkers |
| title |
Biomarkers for Psychosis |
| spellingShingle |
Biomarkers for Psychosis Fuentes-Claramonte, Paola|||0000-0002-1428-7976 Schizophrenia Psychotic disorders Peripheral biomarkers Electrophysiological biomarkers Neuroimaging biomarkers Neuropathological biomarkers |
| title_short |
Biomarkers for Psychosis |
| title_full |
Biomarkers for Psychosis |
| title_fullStr |
Biomarkers for Psychosis |
| title_full_unstemmed |
Biomarkers for Psychosis |
| title_sort |
Biomarkers for Psychosis |
| dc.creator.none.fl_str_mv |
Fuentes-Claramonte, Paola|||0000-0002-1428-7976 Estradé, Andrés|||0000-0001-6871-5932 Solanes, Aleix|||0000-0002-2491-200X Ramella-Cravaro, Valentina Garcia-Leon, Maria Angeles Diego-Adeliño, Javier de|||0000-0001-9708-2441 Molins, Conrad Fung, Eric Valentí, Marc Anmella, Gerard|||0000-0002-6798-4054 Pomarol-Clotet, Edith|||0000-0002-8159-8563 Oliver, Dominic|||0000-0002-8920-3407 Vieta, Eduard|||0000-0002-0548-0053 Radua, Joaquim|||0000-0003-1240-5438 Fusar-Poli, Paolo|||0000-0003-3582-6788 |
| author |
Fuentes-Claramonte, Paola|||0000-0002-1428-7976 |
| author_facet |
Fuentes-Claramonte, Paola|||0000-0002-1428-7976 Estradé, Andrés|||0000-0001-6871-5932 Solanes, Aleix|||0000-0002-2491-200X Ramella-Cravaro, Valentina Garcia-Leon, Maria Angeles Diego-Adeliño, Javier de|||0000-0001-9708-2441 Molins, Conrad Fung, Eric Valentí, Marc Anmella, Gerard|||0000-0002-6798-4054 Pomarol-Clotet, Edith|||0000-0002-8159-8563 Oliver, Dominic|||0000-0002-8920-3407 Vieta, Eduard|||0000-0002-0548-0053 Radua, Joaquim|||0000-0003-1240-5438 Fusar-Poli, Paolo|||0000-0003-3582-6788 |
| author_role |
author |
| author2 |
Estradé, Andrés|||0000-0001-6871-5932 Solanes, Aleix|||0000-0002-2491-200X Ramella-Cravaro, Valentina Garcia-Leon, Maria Angeles Diego-Adeliño, Javier de|||0000-0001-9708-2441 Molins, Conrad Fung, Eric Valentí, Marc Anmella, Gerard|||0000-0002-6798-4054 Pomarol-Clotet, Edith|||0000-0002-8159-8563 Oliver, Dominic|||0000-0002-8920-3407 Vieta, Eduard|||0000-0002-0548-0053 Radua, Joaquim|||0000-0003-1240-5438 Fusar-Poli, Paolo|||0000-0003-3582-6788 |
| author2_role |
author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Schizophrenia Psychotic disorders Peripheral biomarkers Electrophysiological biomarkers Neuroimaging biomarkers Neuropathological biomarkers |
| topic |
Schizophrenia Psychotic disorders Peripheral biomarkers Electrophysiological biomarkers Neuroimaging biomarkers Neuropathological biomarkers |
| description |
This umbrella review aims to comprehensively synthesize the evidence of association between peripheral, electrophysiological, neuroimaging, neuropathological, and other biomarkers and diagnosis of psychotic disorders. We selected systematic reviews and meta-analyses of observational studies on diagnostic biomarkers for psychotic disorders, published until February 1, 2018. Data extraction was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Evidence of association between biomarkers and psychotic disorders was classified as convincing, highly suggestive, suggestive, weak, or non-significant, using a standardized classification. Quality analyses used the Assessment of Multiple Systematic Reviews (AMSTAR) tool. The umbrella review included 110 meta-analyses or systematic reviews corresponding to 3892 individual studies, 1478 biomarkers, and 392 210 participants. No factor showed a convincing level of evidence. Highly suggestive evidence was observed for transglutaminase autoantibodies levels (odds ratio [OR] = 7.32; 95% CI: 3.36, 15.94), mismatch negativity in auditory event-related potentials (standardized mean difference [SMD] = 0.73; 95% CI: 0.5, 0.96), P300 component latency (SMD = -0.6; 95% CI: -0.83, -0.38), ventricle-brain ratio (SMD = 0.61; 95% CI: 0.5, 0.71), and minor physical anomalies (SMD = 0.99; 95% CI: 0.64, 1.34). Suggestive evidence was observed for folate, malondialdehyde, brain-derived neurotrophic factor, homocysteine, P50 sensory gating (P50 S2/S1 ratio), frontal N -acetyl-aspartate, and high-frequency heart rate variability. Among the remaining biomarkers, weak evidence was found for 626 and a non-significant association for 833 factors. While several biomarkers present highly suggestive or suggestive evidence of association with psychotic disorders, methodological biases, and underpowered studies call for future higher-quality research. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/307669 https://dx.doi.org/urn:doi:10.1093/schizbullopen/sgae018 |
| url |
https://ddd.uab.cat/record/307669 https://dx.doi.org/urn:doi:10.1093/schizbullopen/sgae018 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01475 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-01271 "la Caixa" Foundation https://doi.org/10.13039/100010434 100010434 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00394 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00261 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01128 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869407946809540608 |
| score |
15,812455 |