Combining MRI and clinical data to detect high relapse risk after the first episode of psychosis

Detecting patients at high relapse risk after the first episode of psychosis (HRR-FEP) could help the clinician adjust the preventive treatment. To develop a tool to detect patients at HRR using their baseline clinical and structural MRI, we followed 227 patients with FEP for 18-24 months and applie...

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Detalles Bibliográficos
Autores: Solanes, Aleix|||0000-0002-2491-200X, Mezquida, Gisela|||0000-0002-6080-2203, Janssen, Joost|||0000-0001-7613-2067, Amoretti, Silvia|||0000-0001-6017-2734, Lobo, Antonio|||0000-0002-9098-655X, González-Pinto, Ana|||0000-0002-2568-5179, Arango, Celso|||0000-0003-3382-4754, Vieta, Eduard|||0000-0002-0548-0053, Castro-Fornieles, Josefina|||0000-0003-0632-2687, Bergé Baquero, Daniel|||0000-0003-2544-1016, Albacete, Auria|||0000-0003-4156-4972, Giné Serven, Eloi|||0000-0002-3130-5566, Parellada, Mara|||0000-0001-7977-3601, Bernardo, Miquel|||0000-0001-8748-6717, Pomarol-Clotet, Edith|||0000-0002-8159-8563, Radua, Joaquim|||0000-0003-1240-5438
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:269368
Acceso en línea:https://ddd.uab.cat/record/269368
https://dx.doi.org/urn:doi:10.1038/s41537-022-00309-w
Access Level:acceso abierto
Palabra clave:Psychosis
Biomarkers
Schizophrenia
Descripción
Sumario:Detecting patients at high relapse risk after the first episode of psychosis (HRR-FEP) could help the clinician adjust the preventive treatment. To develop a tool to detect patients at HRR using their baseline clinical and structural MRI, we followed 227 patients with FEP for 18-24 months and applied MRIPredict. We previously optimized the MRI-based machine-learning parameters (combining unmodulated and modulated gray and white matter and using voxel-based ensemble) in two independent datasets. Patients estimated to be at HRR-FEP showed a substantially increased risk of relapse (hazard ratio = 4.58, P < 0.05). Accuracy was poorer when we only used clinical or MRI data. We thus show the potential of combining clinical and MRI data to detect which individuals are more likely to relapse, who may benefit from increased frequency of visits, and which are unlikely, who may be currently receiving unnecessary prophylactic treatments. We also provide an updated version of the MRIPredict software.

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