The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression

The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. T...

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Autores: Saurí Duran, Jaume, Millán, D., Suñé i Negre, Josep M. (Josep Maria), Pérez Lozano, Pilar, Sarrate Arjona, Rocio, Fábregas, A. (Anna), Carrillo Sánchez, Carolina, Miñarro Carmona, Montserrat, Ticó Grau, Josep R., García Montoya, Encarna
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/53332
Acceso en línea:https://hdl.handle.net/2445/53332
Access Level:acceso abierto
Palabra clave:Comprimits (Medicina)
Medicació oral
Excipients
Control de qualitat
Medicaments d'alliberament retardat
Tecnologia farmacèutica
Pólvores (Farmàcia)
Tablets (Medicine)
Oral medication
Quality control
Delayed-action drugs
Pharmaceutical technology
Powders (Pharmacy)
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spelling The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compressionSaurí Duran, JaumeMillán, D.Suñé i Negre, Josep M. (Josep Maria)Pérez Lozano, PilarSarrate Arjona, RocioFábregas, A. (Anna)Carrillo Sánchez, CarolinaMiñarro Carmona, MontserratTicó Grau, Josep R.García Montoya, EncarnaComprimits (Medicina)Medicació oralExcipientsControl de qualitatMedicaments d'alliberament retardatTecnologia farmacèuticaPólvores (Farmàcia)Tablets (Medicine)Oral medicationExcipientsQuality controlDelayed-action drugsPharmaceutical technologyPowders (Pharmacy)The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM Diagram Expert System as system responses.Elsevier B.V.2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/53332Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: http://dx.doi.org/10.1016/j.ijpharm.2013.11.029International Journal of Pharmaceutics, 2014, vol. 461, num. 1-2, p. 38-45http://dx.doi.org/10.1016/j.ijpharm.2013.11.029(c) Elsevier B.V., 2014info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/533322026-05-27T06:46:51Z
dc.title.none.fl_str_mv The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
title The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
spellingShingle The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
Saurí Duran, Jaume
Comprimits (Medicina)
Medicació oral
Excipients
Control de qualitat
Medicaments d'alliberament retardat
Tecnologia farmacèutica
Pólvores (Farmàcia)
Tablets (Medicine)
Oral medication
Excipients
Quality control
Delayed-action drugs
Pharmaceutical technology
Powders (Pharmacy)
title_short The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
title_full The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
title_fullStr The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
title_full_unstemmed The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
title_sort The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
dc.creator.none.fl_str_mv Saurí Duran, Jaume
Millán, D.
Suñé i Negre, Josep M. (Josep Maria)
Pérez Lozano, Pilar
Sarrate Arjona, Rocio
Fábregas, A. (Anna)
Carrillo Sánchez, Carolina
Miñarro Carmona, Montserrat
Ticó Grau, Josep R.
García Montoya, Encarna
author Saurí Duran, Jaume
author_facet Saurí Duran, Jaume
Millán, D.
Suñé i Negre, Josep M. (Josep Maria)
Pérez Lozano, Pilar
Sarrate Arjona, Rocio
Fábregas, A. (Anna)
Carrillo Sánchez, Carolina
Miñarro Carmona, Montserrat
Ticó Grau, Josep R.
García Montoya, Encarna
author_role author
author2 Millán, D.
Suñé i Negre, Josep M. (Josep Maria)
Pérez Lozano, Pilar
Sarrate Arjona, Rocio
Fábregas, A. (Anna)
Carrillo Sánchez, Carolina
Miñarro Carmona, Montserrat
Ticó Grau, Josep R.
García Montoya, Encarna
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Comprimits (Medicina)
Medicació oral
Excipients
Control de qualitat
Medicaments d'alliberament retardat
Tecnologia farmacèutica
Pólvores (Farmàcia)
Tablets (Medicine)
Oral medication
Excipients
Quality control
Delayed-action drugs
Pharmaceutical technology
Powders (Pharmacy)
topic Comprimits (Medicina)
Medicació oral
Excipients
Control de qualitat
Medicaments d'alliberament retardat
Tecnologia farmacèutica
Pólvores (Farmàcia)
Tablets (Medicine)
Oral medication
Excipients
Quality control
Delayed-action drugs
Pharmaceutical technology
Powders (Pharmacy)
description The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM Diagram Expert System as system responses.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/53332
url https://hdl.handle.net/2445/53332
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.ijpharm.2013.11.029
International Journal of Pharmaceutics, 2014, vol. 461, num. 1-2, p. 38-45
http://dx.doi.org/10.1016/j.ijpharm.2013.11.029
dc.rights.none.fl_str_mv (c) Elsevier B.V., 2014
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Elsevier B.V., 2014
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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