The use of the SeDeM diagram expert system for the formulation of Captopril SR matrix tablets by direct compression
The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. T...
| Autores: | , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2014 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/53332 |
| Acesso em linha: | https://hdl.handle.net/2445/53332 |
| Access Level: | acceso abierto |
| Palavra-chave: | Comprimits (Medicina) Medicació oral Excipients Control de qualitat Medicaments d'alliberament retardat Tecnologia farmacèutica Pólvores (Farmàcia) Tablets (Medicine) Oral medication Quality control Delayed-action drugs Pharmaceutical technology Powders (Pharmacy) |
| Resumo: | The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. The methodology is based on the implementation of ICH Q8, establishing the design space of the formula with the use of experiment design, using the parameters of the SeDeM Diagram Expert System as system responses. |
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