Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life
Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/200872 |
| Acesso em linha: | https://hdl.handle.net/2445/200872 |
| Access Level: | acceso abierto |
| Palavra-chave: | Malaltia de Parkinson Qualitat de vida Símptomes Parkinson's disease Quality of life Symptoms |
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Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of LifeSantos García, DiegoDeus Fonticoba, Teresa deCores Bartolomé, CarlosFeal Painceiras, Maria J.Íñiguez Alvarado, Maria CristinaGarcía Díaz, IagoJesús, SilviaBuongiorno, Maria TeresaPlanellas, LluísCosgaya, MarinaGarcía Caldentey, JuanCaballol, NúriaLegarda, InesHernández Vara, JorgeCabo, IriaLópez Manzanares, LydiaGonzález Aramburu, IsabelÁvila Rivera, Maria A.Gómez Mayordomo, VíctorNogueira, VíctorPuente, VíctorDotor García-Soto, JulioBorrué, CarmenSolano Vila, BertaÁlvarez Sauco, MaríaVela, LydiaEscalante, SoniaCubo, EstherCarrillo Padilla, FranciscoMartínez Castrillo, Juan C.Sánchez Alonso, PilarAlonso Losada, Maria G.López Ariztegui, NuriaGastón, ItziarKulisevsky, JaimeMenéndez González, ManuelSeijo Martínez, ManuelRuiz Martínez, JavierValero, CaridadKurtis, MónicaGonzález Ardura, JessicaAlonso Redondo, RubenOrdás, CarlosLópez Díaz, Luis M.Mcafee, DarrianCalopa, MatildeCarrillo, FátimaEscamilla Sevilla, FranciscoFreire Alvarez, EricGómez Esteban, Juan CarlosGarcía Ramos, RocíoLuquín, María Rosario IsabelMartínez Torres, IreneSesar Ignacio, ÁngelMartinez Martin, PabloMir, PabloCOPPADIS Study GroupMalaltia de ParkinsonQualitat de vidaSímptomesParkinson's diseaseQuality of lifeSymptomsBackground: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL: 1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05 +/- 7.84 years old; 59% males) were included. MNCD stage was: stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advanced MNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p < 0.0001) and EUROHIS-QOL8 (p < 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD.IOS Press2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/200872Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3233/JPD-225073Journal of Parkinson's Disease, 2023, vol. 13, num. 3, p. 379-402https://doi.org/10.3233/JPD-225073cc by-nc (c) Santos García, Diego et. al.; 2023http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2008722026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life |
| title |
Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life |
| spellingShingle |
Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life Santos García, Diego Malaltia de Parkinson Qualitat de vida Símptomes Parkinson's disease Quality of life Symptoms |
| title_short |
Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life |
| title_full |
Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life |
| title_fullStr |
Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life |
| title_full_unstemmed |
Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life |
| title_sort |
Staging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life |
| dc.creator.none.fl_str_mv |
Santos García, Diego Deus Fonticoba, Teresa de Cores Bartolomé, Carlos Feal Painceiras, Maria J. Íñiguez Alvarado, Maria Cristina García Díaz, Iago Jesús, Silvia Buongiorno, Maria Teresa Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Hernández Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria A. Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Víctor Dotor García-Soto, Julio Borrué, Carmen Solano Vila, Berta Álvarez Sauco, María Vela, Lydia Escalante, Sonia Cubo, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan C. Sánchez Alonso, Pilar Alonso Losada, Maria G. López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Menéndez González, Manuel Seijo Martínez, Manuel Ruiz Martínez, Javier Valero, Caridad Kurtis, Mónica González Ardura, Jessica Alonso Redondo, Ruben Ordás, Carlos López Díaz, Luis M. Mcafee, Darrian Calopa, Matilde Carrillo, Fátima Escamilla Sevilla, Francisco Freire Alvarez, Eric Gómez Esteban, Juan Carlos García Ramos, Rocío Luquín, María Rosario Isabel Martínez Torres, Irene Sesar Ignacio, Ángel Martinez Martin, Pablo Mir, Pablo COPPADIS Study Group |
| author |
Santos García, Diego |
| author_facet |
Santos García, Diego Deus Fonticoba, Teresa de Cores Bartolomé, Carlos Feal Painceiras, Maria J. Íñiguez Alvarado, Maria Cristina García Díaz, Iago Jesús, Silvia Buongiorno, Maria Teresa Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Hernández Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria A. Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Víctor Dotor García-Soto, Julio Borrué, Carmen Solano Vila, Berta Álvarez Sauco, María Vela, Lydia Escalante, Sonia Cubo, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan C. Sánchez Alonso, Pilar Alonso Losada, Maria G. López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Menéndez González, Manuel Seijo Martínez, Manuel Ruiz Martínez, Javier Valero, Caridad Kurtis, Mónica González Ardura, Jessica Alonso Redondo, Ruben Ordás, Carlos López Díaz, Luis M. Mcafee, Darrian Calopa, Matilde Carrillo, Fátima Escamilla Sevilla, Francisco Freire Alvarez, Eric Gómez Esteban, Juan Carlos García Ramos, Rocío Luquín, María Rosario Isabel Martínez Torres, Irene Sesar Ignacio, Ángel Martinez Martin, Pablo Mir, Pablo COPPADIS Study Group |
| author_role |
author |
| author2 |
Deus Fonticoba, Teresa de Cores Bartolomé, Carlos Feal Painceiras, Maria J. Íñiguez Alvarado, Maria Cristina García Díaz, Iago Jesús, Silvia Buongiorno, Maria Teresa Planellas, Lluís Cosgaya, Marina García Caldentey, Juan Caballol, Núria Legarda, Ines Hernández Vara, Jorge Cabo, Iria López Manzanares, Lydia González Aramburu, Isabel Ávila Rivera, Maria A. Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Víctor Dotor García-Soto, Julio Borrué, Carmen Solano Vila, Berta Álvarez Sauco, María Vela, Lydia Escalante, Sonia Cubo, Esther Carrillo Padilla, Francisco Martínez Castrillo, Juan C. Sánchez Alonso, Pilar Alonso Losada, Maria G. López Ariztegui, Nuria Gastón, Itziar Kulisevsky, Jaime Menéndez González, Manuel Seijo Martínez, Manuel Ruiz Martínez, Javier Valero, Caridad Kurtis, Mónica González Ardura, Jessica Alonso Redondo, Ruben Ordás, Carlos López Díaz, Luis M. Mcafee, Darrian Calopa, Matilde Carrillo, Fátima Escamilla Sevilla, Francisco Freire Alvarez, Eric Gómez Esteban, Juan Carlos García Ramos, Rocío Luquín, María Rosario Isabel Martínez Torres, Irene Sesar Ignacio, Ángel Martinez Martin, Pablo Mir, Pablo COPPADIS Study Group |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Malaltia de Parkinson Qualitat de vida Símptomes Parkinson's disease Quality of life Symptoms |
| topic |
Malaltia de Parkinson Qualitat de vida Símptomes Parkinson's disease Quality of life Symptoms |
| description |
Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL: 1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05 +/- 7.84 years old; 59% males) were included. MNCD stage was: stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advanced MNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p < 0.0001) and EUROHIS-QOL8 (p < 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/200872 |
| url |
https://hdl.handle.net/2445/200872 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.3233/JPD-225073 Journal of Parkinson's Disease, 2023, vol. 13, num. 3, p. 379-402 https://doi.org/10.3233/JPD-225073 |
| dc.rights.none.fl_str_mv |
cc by-nc (c) Santos García, Diego et. al.; 2023 http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess |
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cc by-nc (c) Santos García, Diego et. al.; 2023 http://creativecommons.org/licenses/by-nc/3.0/es/ |
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openAccess |
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application/pdf |
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IOS Press |
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IOS Press |
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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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