Patient's awareness on COPD is the strongest predictor of persistence and adherence in treatment-naive patients in real life: a prospective cohort study

Background There is little evidence about the factors that predict persistence/adherence in treatment-naive patients with COPD in clinical practice. The aim of this study was to evaluate persistence and adherence levels among treatment-naive patients diagnosed with COPD who had a prescribed inhaled...

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Autores: Elsa, LP, Justo, G, Blanca, L
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p12711
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/12711
Access Level:acceso abierto
Palabra clave:Chronic obstructive pulmonary disease
Adherence
Persistence
Inhaler medication
Treatment-naive patients
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spelling Patient's awareness on COPD is the strongest predictor of persistence and adherence in treatment-naive patients in real life: a prospective cohort studyElsa, LPJusto, GBlanca, LChronic obstructive pulmonary diseaseAdherencePersistenceInhaler medicationTreatment-naive patientsBackground There is little evidence about the factors that predict persistence/adherence in treatment-naive patients with COPD in clinical practice. The aim of this study was to evaluate persistence and adherence levels among treatment-naive patients diagnosed with COPD who had a prescribed inhaled medication, using data from real-world clinical practice. Methods Multicentric study with a 6 month-followed-up period. Patients were considered persistent if they collected all their inhaler refills. In a random sample of patients, we evaluated adherence using the Test of Adherence to Inhalers (TAI). We assessed Health Related Quality of Life (HRQL) with St George's Respiratory Questionnaire (SGRQ). Results Of the 114 patients included, 46 (40.4%) were defined as persistent. Patients who had awareness about COPD (adjusted RR 2.672, 95% CI 1.125-6.349) were more likely to be persistent; patients with multidose DPI were less likely to be persistent that those with single dose DPI (adjusted RR 0.341, 95% CI 0.133-0.877). Higher levels of SGRQ total were associated with a lower probability of persistence (adjusted RR 0.945, 95%CI 0.894-0.998). Patients who had had an appointment with their GP in the previous six months were more likely to be persistent (adjusted RR 3.107, 95% CI 1.022-9.466). Patients who had awareness about COPD and those with lower symptom SGQR score were more likely to be adherent (24/25, 96.0% vs 16/22, 72.7%, p = 0.025, and mean 29.1, sd 19.4 vs mean 41.4, sd 15.9, respectively, p = 0.026, respectively). Conclusions Less than 50% of patients were defined as persistent. Patients' awareness of their disease and levels of HRQL were associated with high rate of persistence and adherence. In addition, frequent visits to general practitioner, increases the rate of persistence to treatment.BMC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/12711BMC Pulmonary MedicineISSN: 14712466reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p127112026-06-11T12:45:17Z
dc.title.none.fl_str_mv Patient's awareness on COPD is the strongest predictor of persistence and adherence in treatment-naive patients in real life: a prospective cohort study
title Patient's awareness on COPD is the strongest predictor of persistence and adherence in treatment-naive patients in real life: a prospective cohort study
spellingShingle Patient's awareness on COPD is the strongest predictor of persistence and adherence in treatment-naive patients in real life: a prospective cohort study
Elsa, LP
Chronic obstructive pulmonary disease
Adherence
Persistence
Inhaler medication
Treatment-naive patients
title_short Patient's awareness on COPD is the strongest predictor of persistence and adherence in treatment-naive patients in real life: a prospective cohort study
title_full Patient's awareness on COPD is the strongest predictor of persistence and adherence in treatment-naive patients in real life: a prospective cohort study
title_fullStr Patient's awareness on COPD is the strongest predictor of persistence and adherence in treatment-naive patients in real life: a prospective cohort study
title_full_unstemmed Patient's awareness on COPD is the strongest predictor of persistence and adherence in treatment-naive patients in real life: a prospective cohort study
title_sort Patient's awareness on COPD is the strongest predictor of persistence and adherence in treatment-naive patients in real life: a prospective cohort study
dc.creator.none.fl_str_mv Elsa, LP
Justo, G
Blanca, L
author Elsa, LP
author_facet Elsa, LP
Justo, G
Blanca, L
author_role author
author2 Justo, G
Blanca, L
author2_role author
author
dc.subject.none.fl_str_mv Chronic obstructive pulmonary disease
Adherence
Persistence
Inhaler medication
Treatment-naive patients
topic Chronic obstructive pulmonary disease
Adherence
Persistence
Inhaler medication
Treatment-naive patients
description Background There is little evidence about the factors that predict persistence/adherence in treatment-naive patients with COPD in clinical practice. The aim of this study was to evaluate persistence and adherence levels among treatment-naive patients diagnosed with COPD who had a prescribed inhaled medication, using data from real-world clinical practice. Methods Multicentric study with a 6 month-followed-up period. Patients were considered persistent if they collected all their inhaler refills. In a random sample of patients, we evaluated adherence using the Test of Adherence to Inhalers (TAI). We assessed Health Related Quality of Life (HRQL) with St George's Respiratory Questionnaire (SGRQ). Results Of the 114 patients included, 46 (40.4%) were defined as persistent. Patients who had awareness about COPD (adjusted RR 2.672, 95% CI 1.125-6.349) were more likely to be persistent; patients with multidose DPI were less likely to be persistent that those with single dose DPI (adjusted RR 0.341, 95% CI 0.133-0.877). Higher levels of SGRQ total were associated with a lower probability of persistence (adjusted RR 0.945, 95%CI 0.894-0.998). Patients who had had an appointment with their GP in the previous six months were more likely to be persistent (adjusted RR 3.107, 95% CI 1.022-9.466). Patients who had awareness about COPD and those with lower symptom SGQR score were more likely to be adherent (24/25, 96.0% vs 16/22, 72.7%, p = 0.025, and mean 29.1, sd 19.4 vs mean 41.4, sd 15.9, respectively, p = 0.026, respectively). Conclusions Less than 50% of patients were defined as persistent. Patients' awareness of their disease and levels of HRQL were associated with high rate of persistence and adherence. In addition, frequent visits to general practitioner, increases the rate of persistence to treatment.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/12711
url https://fisabio.portalinvestigacion.com/publicaciones/12711
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv BMC Pulmonary Medicine
ISSN: 14712466
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
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