Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation

[EN] Pimaricin (natamycin) is a small polyene macrolide antibiotic used worldwide. This efficient antimycotic and antiprotozoal agent, produced by several soil bacterial species of the genus Streptomyces, has found application in human therapy, in the food and beverage industries and as pesticide. I...

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Autores: Aparicio Fernández, Jesús Manuel, García Barreales, Eva, Diez Payero, Tamara, Morgado Vicente, Cláudia Sofia, Pedro López, Antonio de, Santos Aberturas, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Ajuntament de Barcelona
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/24137
Acceso en línea:https://link.springer.com/article/10.1007/s00253-015-7077-0
https://hdl.handle.net/10612/24137
Access Level:acceso abierto
Palabra clave:Biología
Bioquímica
Biotecnología
Antifungal agent
Cheese
Gene regulation
Keratitis
Metabolic engineering
Polyene macrolide
Preservative E-235
Streptomyces
2414.01 Antibióticos
2415.01 Biología Molecular de Microorganismos
3302.01 Tecnología de Los Antibióticos
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oai_identifier_str oai:buleria.unileon.es:10612/24137
network_acronym_str ES
network_name_str España
repository_id_str
spelling Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulationAparicio Fernández, Jesús ManuelGarcía Barreales, EvaDiez Payero, TamaraMorgado Vicente, Cláudia SofiaPedro López, Antonio deSantos Aberturas, JavierBiologíaBioquímicaBiotecnologíaAntifungal agentCheeseGene regulationKeratitisMetabolic engineeringPolyene macrolidePreservative E-235Streptomyces2414.01 Antibióticos2415.01 Biología Molecular de Microorganismos3302.01 Tecnología de Los Antibióticos[EN] Pimaricin (natamycin) is a small polyene macrolide antibiotic used worldwide. This efficient antimycotic and antiprotozoal agent, produced by several soil bacterial species of the genus Streptomyces, has found application in human therapy, in the food and beverage industries and as pesticide. It displays a broad spectrum of activity, targeting ergosterol but bearing a particular mode of action different to other polyene macrolides. The biosynthesis of this only antifungal agent with a GRAS status has been thoroughly studied, which has permitted the manipulation of producers to engineer the biosynthetic gene clusters in order to generate several analogues. Regulation of its production has been largely unveiled, constituting a model for other polyenes and setting the leads for optimizing the production of these valuable compounds. This review describes and discusses the molecular genetics, uses, mode of action, analogue generation, regulation and strategies for increasing pimaricin production yieldsSIThis work was supported by the Spanish Ministerio de Economía y Competitividad (Grant BIO2013-42983-P to JFA); F.P.U. fellowships from the Ministerio de Educación, Cultura y Deporte (AP2005-3644 to JSA, AP2007-02055 to TDP and FPU13/01537 to AP), a contract from the Junta de Castilla y León co-financed by the European Social Fund (to EGB); and a fellowship from the Portuguese Fundação para a Ciência e a Tecnologia (SFRH/BD/64006/2009 to CMV)SpringerMicrobiologiaFacultad de Ciencias Biologicas y Ambientales2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://link.springer.com/article/10.1007/s00253-015-7077-0https://hdl.handle.net/10612/24137reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Ajuntament de BarcelonaInglésinfo:eu-repo/grantAgreement/MINECO/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/BIO2013-42983-Phttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/241372026-06-24T12:43:27Z
dc.title.none.fl_str_mv Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
title Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
spellingShingle Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
Aparicio Fernández, Jesús Manuel
Biología
Bioquímica
Biotecnología
Antifungal agent
Cheese
Gene regulation
Keratitis
Metabolic engineering
Polyene macrolide
Preservative E-235
Streptomyces
2414.01 Antibióticos
2415.01 Biología Molecular de Microorganismos
3302.01 Tecnología de Los Antibióticos
title_short Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
title_full Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
title_fullStr Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
title_full_unstemmed Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
title_sort Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
dc.creator.none.fl_str_mv Aparicio Fernández, Jesús Manuel
García Barreales, Eva
Diez Payero, Tamara
Morgado Vicente, Cláudia Sofia
Pedro López, Antonio de
Santos Aberturas, Javier
author Aparicio Fernández, Jesús Manuel
author_facet Aparicio Fernández, Jesús Manuel
García Barreales, Eva
Diez Payero, Tamara
Morgado Vicente, Cláudia Sofia
Pedro López, Antonio de
Santos Aberturas, Javier
author_role author
author2 García Barreales, Eva
Diez Payero, Tamara
Morgado Vicente, Cláudia Sofia
Pedro López, Antonio de
Santos Aberturas, Javier
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Microbiologia
Facultad de Ciencias Biologicas y Ambientales
dc.subject.none.fl_str_mv Biología
Bioquímica
Biotecnología
Antifungal agent
Cheese
Gene regulation
Keratitis
Metabolic engineering
Polyene macrolide
Preservative E-235
Streptomyces
2414.01 Antibióticos
2415.01 Biología Molecular de Microorganismos
3302.01 Tecnología de Los Antibióticos
topic Biología
Bioquímica
Biotecnología
Antifungal agent
Cheese
Gene regulation
Keratitis
Metabolic engineering
Polyene macrolide
Preservative E-235
Streptomyces
2414.01 Antibióticos
2415.01 Biología Molecular de Microorganismos
3302.01 Tecnología de Los Antibióticos
description [EN] Pimaricin (natamycin) is a small polyene macrolide antibiotic used worldwide. This efficient antimycotic and antiprotozoal agent, produced by several soil bacterial species of the genus Streptomyces, has found application in human therapy, in the food and beverage industries and as pesticide. It displays a broad spectrum of activity, targeting ergosterol but bearing a particular mode of action different to other polyene macrolides. The biosynthesis of this only antifungal agent with a GRAS status has been thoroughly studied, which has permitted the manipulation of producers to engineer the biosynthetic gene clusters in order to generate several analogues. Regulation of its production has been largely unveiled, constituting a model for other polyenes and setting the leads for optimizing the production of these valuable compounds. This review describes and discusses the molecular genetics, uses, mode of action, analogue generation, regulation and strategies for increasing pimaricin production yields
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://link.springer.com/article/10.1007/s00253-015-7077-0
https://hdl.handle.net/10612/24137
url https://link.springer.com/article/10.1007/s00253-015-7077-0
https://hdl.handle.net/10612/24137
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/BIO2013-42983-P
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Ajuntament de Barcelona
instname_str Ajuntament de Barcelona
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407800700960768
score 15.812429

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