Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
[EN] Pimaricin (natamycin) is a small polyene macrolide antibiotic used worldwide. This efficient antimycotic and antiprotozoal agent, produced by several soil bacterial species of the genus Streptomyces, has found application in human therapy, in the food and beverage industries and as pesticide. I...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Ajuntament de Barcelona |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:buleria.unileon.es:10612/24137 |
| Acceso en línea: | https://link.springer.com/article/10.1007/s00253-015-7077-0 https://hdl.handle.net/10612/24137 |
| Access Level: | acceso abierto |
| Palabra clave: | Biología Bioquímica Biotecnología Antifungal agent Cheese Gene regulation Keratitis Metabolic engineering Polyene macrolide Preservative E-235 Streptomyces 2414.01 Antibióticos 2415.01 Biología Molecular de Microorganismos 3302.01 Tecnología de Los Antibióticos |
| Sumario: | [EN] Pimaricin (natamycin) is a small polyene macrolide antibiotic used worldwide. This efficient antimycotic and antiprotozoal agent, produced by several soil bacterial species of the genus Streptomyces, has found application in human therapy, in the food and beverage industries and as pesticide. It displays a broad spectrum of activity, targeting ergosterol but bearing a particular mode of action different to other polyene macrolides. The biosynthesis of this only antifungal agent with a GRAS status has been thoroughly studied, which has permitted the manipulation of producers to engineer the biosynthetic gene clusters in order to generate several analogues. Regulation of its production has been largely unveiled, constituting a model for other polyenes and setting the leads for optimizing the production of these valuable compounds. This review describes and discusses the molecular genetics, uses, mode of action, analogue generation, regulation and strategies for increasing pimaricin production yields |
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