Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy

Organic and biological compounds (especially those related to the pharmaceutical industry) have always been of great interest for researchers due to their importance for the development of new drugs to diagnose, cure, treat or prevent disease. As many new API (active pharmaceutical ingredients) and...

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Autores: Das, Partha Pratim, Guzzinati, Giulio, Coll, Cristina, Gómez Pérez, Alejandro, Nicolopoulos, Stavros, Estradé Albiol, Sònia, Peiró Martínez, Francisca, Verbeeck, Johan, Zompra, Aikaterini A., Galanis, Athanassios S.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/176302
Acceso en línea:https://hdl.handle.net/2445/176302
Access Level:acceso abierto
Palabra clave:Indústria farmacèutica
Daltonisme
Pharmaceutical industry
Color blindness
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spelling Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL SpectroscopyDas, Partha PratimGuzzinati, GiulioColl, CristinaGómez Pérez, AlejandroNicolopoulos, StavrosEstradé Albiol, SòniaPeiró Martínez, FranciscaVerbeeck, JohanZompra, Aikaterini A.Galanis, Athanassios S.Indústria farmacèuticaDaltonismePharmaceutical industryColor blindnessOrganic and biological compounds (especially those related to the pharmaceutical industry) have always been of great interest for researchers due to their importance for the development of new drugs to diagnose, cure, treat or prevent disease. As many new API (active pharmaceutical ingredients) and their polymorphs are in nanocrystalline or in amorphous form blended with amorphous polymeric matrix (known as amorphous solid dispersion-ASD), their structural identification and characterization at nm scale with conventional X-Ray/Raman/IR techniques becomes difficult. During any API synthesis/production or in the formulated drug product, impurities must be identified and characterized. Electron energy loss spectroscopy (EELS) at high energy resolution by transmission electron microscope (TEM) is expected to be a promising technique to screen and identify the different (organic) compounds used in a typical pharmaceutical or biological system and to detect any impurities present, if any, during the synthesis or formulation process. In this work, we propose the use of monochromated TEM-EELS, to analyze selected peptides and organic compounds and their polymorphs. In order to validate EELS for fingerprinting (in low loss/optical region) and by further correlation with advanced DFT, simulations were utilized.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/176302Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/polym12071434Polymers, 2020, vol. 12, num. 7, p. 1434https://doi.org/10.3390/polym12071434info:eu-repo/grantAgreement/EC/H2020/731019cc-by (c) Das, Partha Pratim et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1763022026-05-27T06:46:51Z
dc.title.none.fl_str_mv Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy
title Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy
spellingShingle Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy
Das, Partha Pratim
Indústria farmacèutica
Daltonisme
Pharmaceutical industry
Color blindness
title_short Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy
title_full Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy
title_fullStr Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy
title_full_unstemmed Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy
title_sort Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy
dc.creator.none.fl_str_mv Das, Partha Pratim
Guzzinati, Giulio
Coll, Cristina
Gómez Pérez, Alejandro
Nicolopoulos, Stavros
Estradé Albiol, Sònia
Peiró Martínez, Francisca
Verbeeck, Johan
Zompra, Aikaterini A.
Galanis, Athanassios S.
author Das, Partha Pratim
author_facet Das, Partha Pratim
Guzzinati, Giulio
Coll, Cristina
Gómez Pérez, Alejandro
Nicolopoulos, Stavros
Estradé Albiol, Sònia
Peiró Martínez, Francisca
Verbeeck, Johan
Zompra, Aikaterini A.
Galanis, Athanassios S.
author_role author
author2 Guzzinati, Giulio
Coll, Cristina
Gómez Pérez, Alejandro
Nicolopoulos, Stavros
Estradé Albiol, Sònia
Peiró Martínez, Francisca
Verbeeck, Johan
Zompra, Aikaterini A.
Galanis, Athanassios S.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Indústria farmacèutica
Daltonisme
Pharmaceutical industry
Color blindness
topic Indústria farmacèutica
Daltonisme
Pharmaceutical industry
Color blindness
description Organic and biological compounds (especially those related to the pharmaceutical industry) have always been of great interest for researchers due to their importance for the development of new drugs to diagnose, cure, treat or prevent disease. As many new API (active pharmaceutical ingredients) and their polymorphs are in nanocrystalline or in amorphous form blended with amorphous polymeric matrix (known as amorphous solid dispersion-ASD), their structural identification and characterization at nm scale with conventional X-Ray/Raman/IR techniques becomes difficult. During any API synthesis/production or in the formulated drug product, impurities must be identified and characterized. Electron energy loss spectroscopy (EELS) at high energy resolution by transmission electron microscope (TEM) is expected to be a promising technique to screen and identify the different (organic) compounds used in a typical pharmaceutical or biological system and to detect any impurities present, if any, during the synthesis or formulation process. In this work, we propose the use of monochromated TEM-EELS, to analyze selected peptides and organic compounds and their polymorphs. In order to validate EELS for fingerprinting (in low loss/optical region) and by further correlation with advanced DFT, simulations were utilized.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/176302
url https://hdl.handle.net/2445/176302
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/polym12071434
Polymers, 2020, vol. 12, num. 7, p. 1434
https://doi.org/10.3390/polym12071434
info:eu-repo/grantAgreement/EC/H2020/731019
dc.rights.none.fl_str_mv cc-by (c) Das, Partha Pratim et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Das, Partha Pratim et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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