Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort

Optical coherence tomography angiography (OCT-A) allows the detection of retinal vessel density (VD) loss, which is a reflection of brain vascular pathology. We aimed to investigate differences in macular VD in the superficial plexus in a large cohort of individuals cognitively unimpaired (CU), with...

Descripción completa

Detalles Bibliográficos
Autores: Marquié, Marta, Castilla-Martí, Miguel, Boada, Mercè
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/55783
Acceso en línea:http://hdl.handle.net/10230/55783
http://dx.doi.org/10.1038/s41598-022-21558-w
Access Level:acceso abierto
Palabra clave:Alzheimer&apos
s disease
Diagnostic markers
id ES_4e841ae68f5a2b85d170d218d0ceecac
oai_identifier_str oai:repositori.upf.edu:10230/55783
network_acronym_str ES
network_name_str España
repository_id_str
spelling Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohortMarquié, MartaCastilla-Martí, MiguelBoada, MercèAlzheimer&aposs diseaseDiagnostic markersOptical coherence tomography angiography (OCT-A) allows the detection of retinal vessel density (VD) loss, which is a reflection of brain vascular pathology. We aimed to investigate differences in macular VD in the superficial plexus in a large cohort of individuals cognitively unimpaired (CU), with mild cognitive impairment due to Alzheimer´s disease (MCI-AD), MCI due to cerebrovascular pathology (MCI-Va), probable Alzheimer´s disease dementia (ADD) and Vascular Dementia (VaD). Clinical, demographical, ophthalmological and OCT-A data from the Neuro-ophthalmology Research at Fundació ACE (NORFACE) project were analyzed. Differences of macular VD in four quadrants (superior, nasal, inferior and temporal) among the five diagnostic groups were assessed in a multivariate regression model, adjusted by age, sex, education, hypertension, diabetes mellitus, heart disease and stroke. The study cohort comprised 672 participants: 128 CU, 120 MCI-AD, 111 MCI-Va, 257 ADD and 56 VaD. Regression analysis showed a significantly higher VD in the temporal quadrant in MCI-AD compared to CU participants (49.05 ± 4.91 vs 47.27 ± 4.17, p = 0.02, d = 0.40), and a significantly lower VD in the inferior quadrant in MCI-Va compared to CU participants (48.70 ± 6.57 vs 51.27 ± 6.39, p = 0.02, d = 0.40). Individuals with heart disease presented significantly lower VD in the inferior quadrant than those without (p = 0.01). The interaction of sex and diagnosis had no effect in differentiating VD. Mini-Mental State Examination (MMSE) scores were not correlated to VD (all r < 0.16; p > 0.07). In conclusion, our study showed that the MCI-AD and MCI-Va groups had significant differences in macular VD in opposite directions in the temporal and inferior quadrants, respectively, compared to CU participants, suggesting that macular VD might be able to differentiate two pathogenic pathways (AD- and cerebrovascular-related) in early stages of cognitive decline.Nature Research202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55783http://dx.doi.org/10.1038/s41598-022-21558-wreponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésSci Rep. 2022 Oct 8;12(1):16938© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/557832026-06-12T07:21:37Z
dc.title.none.fl_str_mv Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort
title Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort
spellingShingle Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort
Marquié, Marta
Alzheimer&apos
s disease
Diagnostic markers
title_short Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort
title_full Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort
title_fullStr Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort
title_full_unstemmed Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort
title_sort Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort
dc.creator.none.fl_str_mv Marquié, Marta
Castilla-Martí, Miguel
Boada, Mercè
author Marquié, Marta
author_facet Marquié, Marta
Castilla-Martí, Miguel
Boada, Mercè
author_role author
author2 Castilla-Martí, Miguel
Boada, Mercè
author2_role author
author
dc.subject.none.fl_str_mv Alzheimer&apos
s disease
Diagnostic markers
topic Alzheimer&apos
s disease
Diagnostic markers
description Optical coherence tomography angiography (OCT-A) allows the detection of retinal vessel density (VD) loss, which is a reflection of brain vascular pathology. We aimed to investigate differences in macular VD in the superficial plexus in a large cohort of individuals cognitively unimpaired (CU), with mild cognitive impairment due to Alzheimer´s disease (MCI-AD), MCI due to cerebrovascular pathology (MCI-Va), probable Alzheimer´s disease dementia (ADD) and Vascular Dementia (VaD). Clinical, demographical, ophthalmological and OCT-A data from the Neuro-ophthalmology Research at Fundació ACE (NORFACE) project were analyzed. Differences of macular VD in four quadrants (superior, nasal, inferior and temporal) among the five diagnostic groups were assessed in a multivariate regression model, adjusted by age, sex, education, hypertension, diabetes mellitus, heart disease and stroke. The study cohort comprised 672 participants: 128 CU, 120 MCI-AD, 111 MCI-Va, 257 ADD and 56 VaD. Regression analysis showed a significantly higher VD in the temporal quadrant in MCI-AD compared to CU participants (49.05 ± 4.91 vs 47.27 ± 4.17, p = 0.02, d = 0.40), and a significantly lower VD in the inferior quadrant in MCI-Va compared to CU participants (48.70 ± 6.57 vs 51.27 ± 6.39, p = 0.02, d = 0.40). Individuals with heart disease presented significantly lower VD in the inferior quadrant than those without (p = 0.01). The interaction of sex and diagnosis had no effect in differentiating VD. Mini-Mental State Examination (MMSE) scores were not correlated to VD (all r < 0.16; p > 0.07). In conclusion, our study showed that the MCI-AD and MCI-Va groups had significant differences in macular VD in opposite directions in the temporal and inferior quadrants, respectively, compared to CU participants, suggesting that macular VD might be able to differentiate two pathogenic pathways (AD- and cerebrovascular-related) in early stages of cognitive decline.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55783
http://dx.doi.org/10.1038/s41598-022-21558-w
url http://hdl.handle.net/10230/55783
http://dx.doi.org/10.1038/s41598-022-21558-w
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sci Rep. 2022 Oct 8;12(1):16938
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407761326931968
score 15,812429

Similares en LA Referencia