Differences in macular vessel density in the superficial plexus across cognitive impairment

Optical coherence tomography angiography (OCT-A) allows the detection of retinal vessel density (VD) loss, which is a reflection of brain vascular pathology. We aimed to investigate differences in macular VD in the superficial plexus in a large cohort of individuals cognitively unimpaired (CU), with...

Descripción completa

Detalles Bibliográficos
Autores: Marquié, Marta|||0000-0002-0660-0950, Valero, Sergi|||0000-0002-6599-948X, Martínez, Joan|||0000-0001-7962-709X, Alarcón-Martín, Emilio|||0000-0002-0985-872X, García-Sánchez, Ainhoa, De Rojas, Itziar|||0000-0002-2148-381X, Castilla Marti, Miguel|||0000-0003-1886-3536, Castilla-Martí, Luis|||0000-0002-7239-5289, Hernández, Isabel|||0000-0001-8119-393X, Rosende-Roca, Maitée|||0000-0003-1778-8175, Vargas, Liliana|||0000-0001-5685-5903, Tartari, Juan Pablo, Esteban de Antonio, Ester|||0000-0003-1965-6010, Bojaryn, Urszula, Pytel, Vanesa, Narvaiza, Leire, Alegret, Montserrat|||0000-0002-8164-9500, Ortega Linares, Gemma|||0000-0002-7479-4072, Espinosa, Ana|||0000-0001-7399-3267, Sanabria, Ángela|||0000-0002-7501-9895, Pérez-Cordón, Alba|||0000-0002-6028-0791, Lleonart, Núria, Muñoz, Nathalia, Tárraga, Lluís|||0000-0002-8423-946X, Ruiz Laza, Agustín|||0000-0003-2633-2495, Boada, Mercè|||0000-0003-2617-3009
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:292165
Acceso en línea:https://ddd.uab.cat/record/292165
https://dx.doi.org/urn:doi:10.1038/s41598-022-21558-w
Access Level:acceso abierto
Palabra clave:Alzheimer Disease
Cognitive Dysfunction
Copper
Fluorescein Angiography
Heart Diseases
Humans
Retinal Vessels
Tomography, Optical Coherence
Descripción
Sumario:Optical coherence tomography angiography (OCT-A) allows the detection of retinal vessel density (VD) loss, which is a reflection of brain vascular pathology. We aimed to investigate differences in macular VD in the superficial plexus in a large cohort of individuals cognitively unimpaired (CU), with mild cognitive impairment due to Alzheimer's disease (MCI-AD), MCI due to cerebrovascular pathology (MCI-Va), probable Alzheimer's disease dementia (ADD) and Vascular Dementia (VaD). Clinical, demographical, ophthalmological and OCT-A data from the Neuro-ophthalmology Research at Fundació ACE (NORFACE) project were analyzed. Differences of macular VD in four quadrants (superior, nasal, inferior and temporal) among the five diagnostic groups were assessed in a multivariate regression model, adjusted by age, sex, education, hypertension, diabetes mellitus, heart disease and stroke. The study cohort comprised 672 participants: 128 CU, 120 MCI-AD, 111 MCI-Va, 257 ADD and 56 VaD. Regression analysis showed a significantly higher VD in the temporal quadrant in MCI-AD compared to CU participants (49.05 ± 4.91 vs 47.27 ± 4.17, p = 0.02, d = 0.40), and a significantly lower VD in the inferior quadrant in MCI-Va compared to CU participants (48.70 ± 6.57 vs 51.27 ± 6.39, p = 0.02, d = 0.40). Individuals with heart disease presented significantly lower VD in the inferior quadrant than those without (p = 0.01). The interaction of sex and diagnosis had no effect in differentiating VD. Mini-Mental State Examination (MMSE) scores were not correlated to VD (all r < 0.16; p.

Similares en LA Referencia