Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system

An advanced potentiometric electronic tongue and Sequential Injection Analysis (SIA) measurement system was applied for the quantitative analysis of mixtures containing three active pharmaceutical ingredients (APIs): acetaminophen, ascorbic acid and acetylsalicylic acid, in the presence of various a...

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Autores: Wesoly, Malgorzata, Cetó, Xavier|||0000-0003-1589-6076, Valle, Manel del|||0000-0002-1032-8611, Ciosek, Patrycja, Wróblewski, Wojciech
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:154708
Acceso en línea:https://ddd.uab.cat/record/154708
https://dx.doi.org/urn:doi:10.1002/elan.201500407
Access Level:acceso abierto
Palabra clave:Pharmaceutical analysis
Active pharmaceutical ingredients (APIs)
Ion-selective electrodes
Automated electronic tongue
Sequential injection analysis
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spelling Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow systemWesoly, MalgorzataCetó, Xavier|||0000-0003-1589-6076Valle, Manel del|||0000-0002-1032-8611Ciosek, PatrycjaWróblewski, WojciechPharmaceutical analysisActive pharmaceutical ingredients (APIs)Ion-selective electrodesAutomated electronic tongueSequential injection analysisAn advanced potentiometric electronic tongue and Sequential Injection Analysis (SIA) measurement system was applied for the quantitative analysis of mixtures containing three active pharmaceutical ingredients (APIs): acetaminophen, ascorbic acid and acetylsalicylic acid, in the presence of various amounts of caffeine as interferent. The flow-through sensor array was composed of miniaturized classical ion-selective electrodes based on plasticized PVC membranes containing only ion exchangers. Partial Least Squares (PLS) analysis of the steady-state sensor array responses, measured in API mixtures prepared by the SIA system permitted a correct quantitative analysis of acetylsalicylic acid and ascorbic acid. Further optimization using multiway PLS fed by dynamic responses without additional feature extraction did not improve significantly the resolution of acetaminophen. Lastly, the chemometric treatment, involving the extraction of dynamic components of the transient response employing the Wavelet transform, the removal of less-significant coefficients by means of Causal Index pruning and training of an Artificial Neural Network (ANN) with the selected coefficients, allowed the simultaneous determination of all the three studied APIs, while counterbalancing any interference due to caffeine. 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501SMURhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/154708https://dx.doi.org/urn:doi:10.1002/elan.201500407reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1547082026-06-06T12:50:31Z
dc.title.none.fl_str_mv Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system
title Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system
spellingShingle Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system
Wesoly, Malgorzata
Pharmaceutical analysis
Active pharmaceutical ingredients (APIs)
Ion-selective electrodes
Automated electronic tongue
Sequential injection analysis
title_short Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system
title_full Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system
title_fullStr Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system
title_full_unstemmed Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system
title_sort Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system
dc.creator.none.fl_str_mv Wesoly, Malgorzata
Cetó, Xavier|||0000-0003-1589-6076
Valle, Manel del|||0000-0002-1032-8611
Ciosek, Patrycja
Wróblewski, Wojciech
author Wesoly, Malgorzata
author_facet Wesoly, Malgorzata
Cetó, Xavier|||0000-0003-1589-6076
Valle, Manel del|||0000-0002-1032-8611
Ciosek, Patrycja
Wróblewski, Wojciech
author_role author
author2 Cetó, Xavier|||0000-0003-1589-6076
Valle, Manel del|||0000-0002-1032-8611
Ciosek, Patrycja
Wróblewski, Wojciech
author2_role author
author
author
author
dc.subject.none.fl_str_mv Pharmaceutical analysis
Active pharmaceutical ingredients (APIs)
Ion-selective electrodes
Automated electronic tongue
Sequential injection analysis
topic Pharmaceutical analysis
Active pharmaceutical ingredients (APIs)
Ion-selective electrodes
Automated electronic tongue
Sequential injection analysis
description An advanced potentiometric electronic tongue and Sequential Injection Analysis (SIA) measurement system was applied for the quantitative analysis of mixtures containing three active pharmaceutical ingredients (APIs): acetaminophen, ascorbic acid and acetylsalicylic acid, in the presence of various amounts of caffeine as interferent. The flow-through sensor array was composed of miniaturized classical ion-selective electrodes based on plasticized PVC membranes containing only ion exchangers. Partial Least Squares (PLS) analysis of the steady-state sensor array responses, measured in API mixtures prepared by the SIA system permitted a correct quantitative analysis of acetylsalicylic acid and ascorbic acid. Further optimization using multiway PLS fed by dynamic responses without additional feature extraction did not improve significantly the resolution of acetaminophen. Lastly, the chemometric treatment, involving the extraction of dynamic components of the transient response employing the Wavelet transform, the removal of less-significant coefficients by means of Causal Index pruning and training of an Artificial Neural Network (ANN) with the selected coefficients, allowed the simultaneous determination of all the three studied APIs, while counterbalancing any interference due to caffeine.
publishDate 2016
dc.date.none.fl_str_mv 2
2016-01-01
2016
2016-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
SMUR
http://purl.org/coar/version/c_71e4c1898caa6e32
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/154708
https://dx.doi.org/urn:doi:10.1002/elan.201500407
url https://ddd.uab.cat/record/154708
https://dx.doi.org/urn:doi:10.1002/elan.201500407
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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