Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus

Endothelial senescence-associated with aging or induced prematurely in pathological situations, such as diabetes, is a first step in the development of Cardiovascular Disease (CVDs) and particularly inflammatory cardiovascular diseases. The main mechanism that links endothelial senescence and the pr...

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Autores: Carracedo, Julia, Alique Aguilar, Matilde|||0000-0002-7912-1133, Ramírez Carracedo, Rafael, Bodega Magro, Guillermo|||0000-0003-1469-3242, Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/64761
Acceso en línea:http://hdl.handle.net/10017/64761
https://dx.doi.org/10.2174/1570161116666180820115726
Access Level:acceso abierto
Palabra clave:Cardiovascular diseases
Diabetes
Endothelial senescence
Epigenetic signals
Extracellular vesicles
Microvesicles
Physiopathological mechanisms
Medicina
Medicine
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spelling Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes MellitusCarracedo, JuliaAlique Aguilar, Matilde|||0000-0002-7912-1133Ramírez Carracedo, RafaelBodega Magro, Guillermo|||0000-0003-1469-3242Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339XCardiovascular diseasesDiabetesEndothelial senescenceEpigenetic signalsExtracellular vesiclesMicrovesiclesPhysiopathological mechanismsMedicinaMedicineEndothelial senescence-associated with aging or induced prematurely in pathological situations, such as diabetes, is a first step in the development of Cardiovascular Disease (CVDs) and particularly inflammatory cardiovascular diseases. The main mechanism that links endothelial senescence and the progression of CVDs is the production of altered Extracellular Vesicles (EVs) by senescent endothelial cells among them, Microvesicles (MVs). MVs are recognized as intercellular signaling elements that play a key role in regulating tissue homeostasis. However, MVs produced by damage cell conveyed epigenetic signals, mainly involving microRNAs, which induce many of the injured responses in other vascular cells leading to the development of CVDs. Many studies strongly support that the quantification and characterization of the MVs released by senescent endothelial cells may be useful diagnostic tools in patients with CVDs, as well as a future therapeutic target for these diseases. In this review, we summarize the current knowledge linking senescence-associated MVs to the development of CVDs and discuss the roles of these MVs, in particular, in diabetic-associated increases the risk of CVDs.20192019-08-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/64761https://dx.doi.org/10.2174/1570161116666180820115726reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/647612026-06-18T11:13:07Z
dc.title.none.fl_str_mv Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus
title Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus
spellingShingle Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus
Carracedo, Julia
Cardiovascular diseases
Diabetes
Endothelial senescence
Epigenetic signals
Extracellular vesicles
Microvesicles
Physiopathological mechanisms
Medicina
Medicine
title_short Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus
title_full Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus
title_fullStr Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus
title_full_unstemmed Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus
title_sort Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus
dc.creator.none.fl_str_mv Carracedo, Julia
Alique Aguilar, Matilde|||0000-0002-7912-1133
Ramírez Carracedo, Rafael
Bodega Magro, Guillermo|||0000-0003-1469-3242
Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
author Carracedo, Julia
author_facet Carracedo, Julia
Alique Aguilar, Matilde|||0000-0002-7912-1133
Ramírez Carracedo, Rafael
Bodega Magro, Guillermo|||0000-0003-1469-3242
Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
author_role author
author2 Alique Aguilar, Matilde|||0000-0002-7912-1133
Ramírez Carracedo, Rafael
Bodega Magro, Guillermo|||0000-0003-1469-3242
Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X
author2_role author
author
author
author
dc.subject.none.fl_str_mv Cardiovascular diseases
Diabetes
Endothelial senescence
Epigenetic signals
Extracellular vesicles
Microvesicles
Physiopathological mechanisms
Medicina
Medicine
topic Cardiovascular diseases
Diabetes
Endothelial senescence
Epigenetic signals
Extracellular vesicles
Microvesicles
Physiopathological mechanisms
Medicina
Medicine
description Endothelial senescence-associated with aging or induced prematurely in pathological situations, such as diabetes, is a first step in the development of Cardiovascular Disease (CVDs) and particularly inflammatory cardiovascular diseases. The main mechanism that links endothelial senescence and the progression of CVDs is the production of altered Extracellular Vesicles (EVs) by senescent endothelial cells among them, Microvesicles (MVs). MVs are recognized as intercellular signaling elements that play a key role in regulating tissue homeostasis. However, MVs produced by damage cell conveyed epigenetic signals, mainly involving microRNAs, which induce many of the injured responses in other vascular cells leading to the development of CVDs. Many studies strongly support that the quantification and characterization of the MVs released by senescent endothelial cells may be useful diagnostic tools in patients with CVDs, as well as a future therapeutic target for these diseases. In this review, we summarize the current knowledge linking senescence-associated MVs to the development of CVDs and discuss the roles of these MVs, in particular, in diabetic-associated increases the risk of CVDs.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-08-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/64761
https://dx.doi.org/10.2174/1570161116666180820115726
url http://hdl.handle.net/10017/64761
https://dx.doi.org/10.2174/1570161116666180820115726
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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