Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strains

Schizophrenia involves positive, negative and cognitive symptoms, as well as comorbidity with anxiety and obsessive-compulsive disorder. Prepulse inhibition (PPI) of the startle response is a measure of sensorimotor gating that is impaired in schizophrenia and animal models of the disease. Remarkabl...

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Autores: Tapias-Espinosa, Carles|||0000-0003-3110-0138, Río-Álamos, Cristóbal|||0000-0002-5676-4494, Sampedro-Viana, Daniel|||0000-0003-3922-4039, Gerbolés, Cristina|||0000-0002-9587-1014, Oliveras, Ignasi|||0000-0002-3082-0355, Sánchez González, Ana, Tobeña, Adolf|||0000-0001-6137-0660, Fernández-Teruel, Alberto|||0000-0001-5993-7058
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:285954
Acceso en línea:https://ddd.uab.cat/record/285954
https://dx.doi.org/urn:doi:10.1016/j.beproc.2018.03.019
Access Level:acceso abierto
Palabra clave:Prepulse inhibition
Schizophrenia
Exploratory activity
Compulsive-like behavior
Genetically heterogeneous rats
Roman rats
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spelling Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strainsTapias-Espinosa, Carles|||0000-0003-3110-0138Río-Álamos, Cristóbal|||0000-0002-5676-4494Sampedro-Viana, Daniel|||0000-0003-3922-4039Gerbolés, Cristina|||0000-0002-9587-1014Oliveras, Ignasi|||0000-0002-3082-0355Sánchez González, AnaTobeña, Adolf|||0000-0001-6137-0660Fernández-Teruel, Alberto|||0000-0001-5993-7058Prepulse inhibitionSchizophreniaExploratory activityCompulsive-like behaviorGenetically heterogeneous ratsRoman ratsSchizophrenia involves positive, negative and cognitive symptoms, as well as comorbidity with anxiety and obsessive-compulsive disorder. Prepulse inhibition (PPI) of the startle response is a measure of sensorimotor gating that is impaired in schizophrenia and animal models of the disease. Remarkably, impaired PPI has been related to other schizophrenia-like features in rodent models, such as cognitive deficits and hyperactivity. However, it remains to be investigated whether deficient PPI and increased exploratory activity are associated in genetically heterogeneous (outbred) naïve animals. This study was undertaken to evaluate the relationships among PPI and other schizophrenia-related symptoms, such as augmented exploratory activity, anxiety and compulsivity in the genetically heterogeneous (outbred) NIH-HS rat stock (HS) and in the genetically-selected inbred Roman High-Avoidance (RHA) and Low-avoidance (RLA) rats. Animals underwent the following tests: open-field (exploratory activity), elevated zero-maze (anxiety-like behavior), marble burying (compulsive-like behavior), and PPI. Three groups of HS rats were formed according to their PPI scores, i.e. Low-PPI, Medium-PPI and High-PPI. The HS Low-PPI group displayed higher exploratory activity in the open-field than the HS Medium-PPI and HS High-PPI groups. Likewise, compared with their RLA counterparts, RHA rats exhibited lower PPI and more intense exploratory activity in the open-field test. Correlational and factorial analyses of the whole HS sample and the RHA/RLA data globally corroborated the results of the PPI-stratified HS subgroups. These data suggest that such a consistent association between impaired PPI and increased exploratory activity in outbred HS and inbred RHA/RLA rats is a relevant parameter that must be taken into account when modeling clusters of schizophrenia-relevant symptoms.Universitat Autònoma de Barcelona. Institut de Neurociències 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/285954https://dx.doi.org/urn:doi:10.1016/j.beproc.2018.03.019reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 PSI2013-41872-PAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PSI2017-82257-PAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-1587Ministerio de Educación, Cultura y Deporte https://doi.org/10.13039/501100003176 FPU15/06307open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2859542026-06-06T12:50:31Z
dc.title.none.fl_str_mv Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strains
title Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strains
spellingShingle Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strains
Tapias-Espinosa, Carles|||0000-0003-3110-0138
Prepulse inhibition
Schizophrenia
Exploratory activity
Compulsive-like behavior
Genetically heterogeneous rats
Roman rats
title_short Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strains
title_full Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strains
title_fullStr Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strains
title_full_unstemmed Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strains
title_sort Increased exploratory activity in rats with deficient sensorimotor gating: a study of schizophrenia-relevant symptoms with genetically heterogeneous NIH-HS and Roman rat strains
dc.creator.none.fl_str_mv Tapias-Espinosa, Carles|||0000-0003-3110-0138
Río-Álamos, Cristóbal|||0000-0002-5676-4494
Sampedro-Viana, Daniel|||0000-0003-3922-4039
Gerbolés, Cristina|||0000-0002-9587-1014
Oliveras, Ignasi|||0000-0002-3082-0355
Sánchez González, Ana
Tobeña, Adolf|||0000-0001-6137-0660
Fernández-Teruel, Alberto|||0000-0001-5993-7058
author Tapias-Espinosa, Carles|||0000-0003-3110-0138
author_facet Tapias-Espinosa, Carles|||0000-0003-3110-0138
Río-Álamos, Cristóbal|||0000-0002-5676-4494
Sampedro-Viana, Daniel|||0000-0003-3922-4039
Gerbolés, Cristina|||0000-0002-9587-1014
Oliveras, Ignasi|||0000-0002-3082-0355
Sánchez González, Ana
Tobeña, Adolf|||0000-0001-6137-0660
Fernández-Teruel, Alberto|||0000-0001-5993-7058
author_role author
author2 Río-Álamos, Cristóbal|||0000-0002-5676-4494
Sampedro-Viana, Daniel|||0000-0003-3922-4039
Gerbolés, Cristina|||0000-0002-9587-1014
Oliveras, Ignasi|||0000-0002-3082-0355
Sánchez González, Ana
Tobeña, Adolf|||0000-0001-6137-0660
Fernández-Teruel, Alberto|||0000-0001-5993-7058
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Institut de Neurociències
dc.subject.none.fl_str_mv Prepulse inhibition
Schizophrenia
Exploratory activity
Compulsive-like behavior
Genetically heterogeneous rats
Roman rats
topic Prepulse inhibition
Schizophrenia
Exploratory activity
Compulsive-like behavior
Genetically heterogeneous rats
Roman rats
description Schizophrenia involves positive, negative and cognitive symptoms, as well as comorbidity with anxiety and obsessive-compulsive disorder. Prepulse inhibition (PPI) of the startle response is a measure of sensorimotor gating that is impaired in schizophrenia and animal models of the disease. Remarkably, impaired PPI has been related to other schizophrenia-like features in rodent models, such as cognitive deficits and hyperactivity. However, it remains to be investigated whether deficient PPI and increased exploratory activity are associated in genetically heterogeneous (outbred) naïve animals. This study was undertaken to evaluate the relationships among PPI and other schizophrenia-related symptoms, such as augmented exploratory activity, anxiety and compulsivity in the genetically heterogeneous (outbred) NIH-HS rat stock (HS) and in the genetically-selected inbred Roman High-Avoidance (RHA) and Low-avoidance (RLA) rats. Animals underwent the following tests: open-field (exploratory activity), elevated zero-maze (anxiety-like behavior), marble burying (compulsive-like behavior), and PPI. Three groups of HS rats were formed according to their PPI scores, i.e. Low-PPI, Medium-PPI and High-PPI. The HS Low-PPI group displayed higher exploratory activity in the open-field than the HS Medium-PPI and HS High-PPI groups. Likewise, compared with their RLA counterparts, RHA rats exhibited lower PPI and more intense exploratory activity in the open-field test. Correlational and factorial analyses of the whole HS sample and the RHA/RLA data globally corroborated the results of the PPI-stratified HS subgroups. These data suggest that such a consistent association between impaired PPI and increased exploratory activity in outbred HS and inbred RHA/RLA rats is a relevant parameter that must be taken into account when modeling clusters of schizophrenia-relevant symptoms.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/285954
https://dx.doi.org/urn:doi:10.1016/j.beproc.2018.03.019
url https://ddd.uab.cat/record/285954
https://dx.doi.org/urn:doi:10.1016/j.beproc.2018.03.019
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PSI2013-41872-P
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PSI2017-82257-P
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-1587
Ministerio de Educación, Cultura y Deporte https://doi.org/10.13039/501100003176 FPU15/06307
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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