Decreased activation of parvalbumin interneurons in the medial prefrontal cortex in intact inbred Roman rats with schizophrenia-like reduced sensorimotor gating

Prepulse inhibition (PPI) allows assessing schizophrenia-like sensorimotor gating deficits in rodents. Previous studies indicate that PPI is modulated by the medial prefrontal cortex (mPFC), which is in agreement with our findings showing that PPI differences in the Roman rats are associated with di...

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Detalles Bibliográficos
Autores: Tapias-Espinosa, Carles|||0000-0003-3110-0138, Sánchez González, Ana, Cañete, Toni|||0000-0002-8950-8120, Sampedro-Viana, Daniel|||0000-0003-3922-4039, Castillo-Ruiz, Mª del Mar|||0000-0001-8176-1976, Tobeña, Adolf|||0000-0001-6137-0660, Oliveras, Ignasi|||0000-0002-3082-0355, Fernández-Teruel, Alberto|||0000-0001-5993-7058, Aznar, Susana|||0000-0001-7940-6246
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:285965
Acceso en línea:https://ddd.uab.cat/record/285965
https://dx.doi.org/urn:doi:10.1016/j.bbr.2022.114113
Access Level:acceso abierto
Palabra clave:Parvalbumin
Prepulse inhibition
Psd-95
Roman rats
Schizophrenia
C-fos
Descripción
Sumario:Prepulse inhibition (PPI) allows assessing schizophrenia-like sensorimotor gating deficits in rodents. Previous studies indicate that PPI is modulated by the medial prefrontal cortex (mPFC), which is in agreement with our findings showing that PPI differences in the Roman rats are associated with divergences in mPFC activity. Here, we explore whether differences in PPI and mPFC activity in male Roman rats can be explained by (i) differences in the activation (c-Fos) of inhibitory neurons (parvalbumin (PV) interneurons); and/or (ii) reduced excitatory drive (PSD-95) to PV interneurons. Our data show that low PPI in the Roman high-avoidance (RHA) rats is associated with reduced activation of PV interneurons. Moreover, the RHA rats exhibit decreased density of both PV interneurons and PSD-95 puncta on active PV interneurons. These findings point to reduced cortical inhibition as a candidate to explain the schizophrenia-like features observed in RHA rats and support the role of impaired cortical inhibition in schizophrenia.

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