Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.

A prospective two dimensional and Doppler echocardiographic study of 70 consecutive patients with systemic lupus erythematosus (SLE) and 40 controls was carried out. Forty patients (57%) were found to have echocardiographic disturbance. Valvular abnormalities were detected in 31 patients (44%) and i...

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Detalles Bibliográficos
Autores: Cervera i Segura, Ricard, 1960-, Font Franco, Josep, 1953-2006, Pare i Bardera, J. Carles, Azqueta, Manuel, Pérez Villa, Félix, López-Soto, Alfonso, Ingelmo Morín, Miguel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1992
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/22455
Acceso en línea:https://hdl.handle.net/2445/22455
Access Level:acceso abierto
Palabra clave:Lupus eritematós
Malalties del cor
Estudi de casos
Lupus erythematosus
Heart diseases
Case studies
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spelling Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.Cervera i Segura, Ricard, 1960-Font Franco, Josep, 1953-2006Pare i Bardera, J. CarlesAzqueta, ManuelPérez Villa, FélixLópez-Soto, AlfonsoIngelmo Morín, MiguelLupus eritematósMalalties del corEstudi de casosLupus erythematosusHeart diseasesCase studiesA prospective two dimensional and Doppler echocardiographic study of 70 consecutive patients with systemic lupus erythematosus (SLE) and 40 controls was carried out. Forty patients (57%) were found to have echocardiographic disturbance. Valvular abnormalities were detected in 31 patients (44%) and in only two controls (5%). Mitral valve abnormalities were the most common findings (23/70 (33%)) with mild or moderate regurgitation the most frequent lesion (16% and 9% respectively). Three patients (4%) had a morphological echocardiographic pattern suggestive of non-infective verrucous vegetations affecting the mitral valve. No patient had haemodynamically significant clinical valve disease. Pericardial effusion was identified in 19 patients (27%), of whom 14 had mild and clinically silent disease. Myocardial abnormalities were found in 14 patients (20%), but clinical features of myocardial dysfunction were present in only one. Patients with antiphospholipid antibodies were found to have an increased prevalence of endocardial lesions, mainly valvular regurgitation. It is concluded that the inclusion of echocardiography in a study protocol of patients with SLE can identify an important subset of patients with cardiac abnormalities, many of which are clinically silent. In addition, the association of antiphospholipid antibodies with endocardial lesions suggests that these antibodies may have a prominent role in the pathogenetic mechanisms of heart valve disease in SLE.BMJ Group201220121992info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion4 p.application/pdfhttps://hdl.handle.net/2445/22455Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció digital del document publicat a: http://dx.doi.org/10.1136/ard.51.2.156Annals of the Rheumatic Diseases, 1992, vol. 51, núm. 2, p. 156-159http://dx.doi.org/10.1136/ard.51.2.156(c) BMJ Publishing Group Ltd, 1992info:eu-repo/semantics/openAccessoai:recercat.cat:2445/224552026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.
title Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.
spellingShingle Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.
Cervera i Segura, Ricard, 1960-
Lupus eritematós
Malalties del cor
Estudi de casos
Lupus erythematosus
Heart diseases
Case studies
title_short Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.
title_full Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.
title_fullStr Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.
title_full_unstemmed Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.
title_sort Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.
dc.creator.none.fl_str_mv Cervera i Segura, Ricard, 1960-
Font Franco, Josep, 1953-2006
Pare i Bardera, J. Carles
Azqueta, Manuel
Pérez Villa, Félix
López-Soto, Alfonso
Ingelmo Morín, Miguel
author Cervera i Segura, Ricard, 1960-
author_facet Cervera i Segura, Ricard, 1960-
Font Franco, Josep, 1953-2006
Pare i Bardera, J. Carles
Azqueta, Manuel
Pérez Villa, Félix
López-Soto, Alfonso
Ingelmo Morín, Miguel
author_role author
author2 Font Franco, Josep, 1953-2006
Pare i Bardera, J. Carles
Azqueta, Manuel
Pérez Villa, Félix
López-Soto, Alfonso
Ingelmo Morín, Miguel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Lupus eritematós
Malalties del cor
Estudi de casos
Lupus erythematosus
Heart diseases
Case studies
topic Lupus eritematós
Malalties del cor
Estudi de casos
Lupus erythematosus
Heart diseases
Case studies
description A prospective two dimensional and Doppler echocardiographic study of 70 consecutive patients with systemic lupus erythematosus (SLE) and 40 controls was carried out. Forty patients (57%) were found to have echocardiographic disturbance. Valvular abnormalities were detected in 31 patients (44%) and in only two controls (5%). Mitral valve abnormalities were the most common findings (23/70 (33%)) with mild or moderate regurgitation the most frequent lesion (16% and 9% respectively). Three patients (4%) had a morphological echocardiographic pattern suggestive of non-infective verrucous vegetations affecting the mitral valve. No patient had haemodynamically significant clinical valve disease. Pericardial effusion was identified in 19 patients (27%), of whom 14 had mild and clinically silent disease. Myocardial abnormalities were found in 14 patients (20%), but clinical features of myocardial dysfunction were present in only one. Patients with antiphospholipid antibodies were found to have an increased prevalence of endocardial lesions, mainly valvular regurgitation. It is concluded that the inclusion of echocardiography in a study protocol of patients with SLE can identify an important subset of patients with cardiac abnormalities, many of which are clinically silent. In addition, the association of antiphospholipid antibodies with endocardial lesions suggests that these antibodies may have a prominent role in the pathogenetic mechanisms of heart valve disease in SLE.
publishDate 1992
dc.date.none.fl_str_mv 1992
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/22455
url https://hdl.handle.net/2445/22455
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció digital del document publicat a: http://dx.doi.org/10.1136/ard.51.2.156
Annals of the Rheumatic Diseases, 1992, vol. 51, núm. 2, p. 156-159
http://dx.doi.org/10.1136/ard.51.2.156
dc.rights.none.fl_str_mv (c) BMJ Publishing Group Ltd, 1992
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) BMJ Publishing Group Ltd, 1992
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 4 p.
application/pdf
dc.publisher.none.fl_str_mv BMJ Group
publisher.none.fl_str_mv BMJ Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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