Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial
Scope: To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals. Methods and results: In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, the 1-year effects on atherothrombosis markers of an interve...
| Autores: | , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/171703 |
| Acceso en línea: | https://hdl.handle.net/2445/171703 |
| Access Level: | acceso abierto |
| Palabra clave: | Cuina mediterrània Dieta Malalties cardiovasculars Mediterranean cooking Diet Cardiovascular diseases |
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Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled TrialHernáez Camba, ÁlvaroCastañer, OlgaTresserra i Rimbau, AnnaPintó Sala, XavierFitó Colomer, MontserratCasas Rodríguez, Rosa M.Martínez-González, Miguel Ángel, 1957-Corella Piquer, DoloresSalas Salvadó, JordiLapetra, JoséGómez-Gracia, EnriqueArós, FernandoFiol Sala, MiguelSerra Majem, LluísRos Rahola, EmilioEstruch Riba, RamonCuina mediterràniaDietaMalalties cardiovascularsMediterranean cookingDietCardiovascular diseasesScope: To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals. Methods and results: In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n = 120) or nuts (MedDiet-Nuts; n = 119) versus a low-fat control diet (n = 119), and whether large increments in MedDiet adherence (≥3 score points, versus compliance decreases) and intake changes in key food items are associated with 1-year differences in biomarkers. Differences are observed between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in high-density lipoproteins (HDLs) (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound 1-antitrypsin levels (−6.1% [−11.8; −0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (−9.3% [−18.1; −0.53]). Large MedDiet adherence increments are associated with less fibrinogen (−9.5% [−18.3; −0.60]) and non-esterified fatty acid concentrations (−16.7% [−31.7; −1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake are linked to enhancements in biomarkers. Conclusion: MedDiet improves atherothrombosis biomarkers in high cardiovascular risk individuals.Wiley-VCH2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/171703Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1002/mnfr.202000350Molecular Nutrition & Food Research, 2020https://doi.org/10.1002/mnfr.202000350(c) Wiley-VCH, 2020info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1717032026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial |
| title |
Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial |
| spellingShingle |
Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial Hernáez Camba, Álvaro Cuina mediterrània Dieta Malalties cardiovasculars Mediterranean cooking Diet Cardiovascular diseases |
| title_short |
Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial |
| title_full |
Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial |
| title_fullStr |
Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial |
| title_full_unstemmed |
Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial |
| title_sort |
Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial |
| dc.creator.none.fl_str_mv |
Hernáez Camba, Álvaro Castañer, Olga Tresserra i Rimbau, Anna Pintó Sala, Xavier Fitó Colomer, Montserrat Casas Rodríguez, Rosa M. Martínez-González, Miguel Ángel, 1957- Corella Piquer, Dolores Salas Salvadó, Jordi Lapetra, José Gómez-Gracia, Enrique Arós, Fernando Fiol Sala, Miguel Serra Majem, Lluís Ros Rahola, Emilio Estruch Riba, Ramon |
| author |
Hernáez Camba, Álvaro |
| author_facet |
Hernáez Camba, Álvaro Castañer, Olga Tresserra i Rimbau, Anna Pintó Sala, Xavier Fitó Colomer, Montserrat Casas Rodríguez, Rosa M. Martínez-González, Miguel Ángel, 1957- Corella Piquer, Dolores Salas Salvadó, Jordi Lapetra, José Gómez-Gracia, Enrique Arós, Fernando Fiol Sala, Miguel Serra Majem, Lluís Ros Rahola, Emilio Estruch Riba, Ramon |
| author_role |
author |
| author2 |
Castañer, Olga Tresserra i Rimbau, Anna Pintó Sala, Xavier Fitó Colomer, Montserrat Casas Rodríguez, Rosa M. Martínez-González, Miguel Ángel, 1957- Corella Piquer, Dolores Salas Salvadó, Jordi Lapetra, José Gómez-Gracia, Enrique Arós, Fernando Fiol Sala, Miguel Serra Majem, Lluís Ros Rahola, Emilio Estruch Riba, Ramon |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Cuina mediterrània Dieta Malalties cardiovasculars Mediterranean cooking Diet Cardiovascular diseases |
| topic |
Cuina mediterrània Dieta Malalties cardiovasculars Mediterranean cooking Diet Cardiovascular diseases |
| description |
Scope: To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals. Methods and results: In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n = 120) or nuts (MedDiet-Nuts; n = 119) versus a low-fat control diet (n = 119), and whether large increments in MedDiet adherence (≥3 score points, versus compliance decreases) and intake changes in key food items are associated with 1-year differences in biomarkers. Differences are observed between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in high-density lipoproteins (HDLs) (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound 1-antitrypsin levels (−6.1% [−11.8; −0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (−9.3% [−18.1; −0.53]). Large MedDiet adherence increments are associated with less fibrinogen (−9.5% [−18.3; −0.60]) and non-esterified fatty acid concentrations (−16.7% [−31.7; −1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake are linked to enhancements in biomarkers. Conclusion: MedDiet improves atherothrombosis biomarkers in high cardiovascular risk individuals. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/171703 |
| url |
https://hdl.handle.net/2445/171703 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.202000350 Molecular Nutrition & Food Research, 2020 https://doi.org/10.1002/mnfr.202000350 |
| dc.rights.none.fl_str_mv |
(c) Wiley-VCH, 2020 info:eu-repo/semantics/openAccess |
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(c) Wiley-VCH, 2020 |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley-VCH |
| publisher.none.fl_str_mv |
Wiley-VCH |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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15,301603 |