Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial

Scope: To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals. Methods and results: In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, the 1-year effects on atherothrombosis markers of an interve...

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Detalles Bibliográficos
Autores: Hernáez Camba, Álvaro, Castañer, Olga, Tresserra i Rimbau, Anna, Pintó Sala, Xavier, Fitó Colomer, Montserrat, Casas Rodríguez, Rosa M., Martínez-González, Miguel Ángel, 1957-, Corella Piquer, Dolores, Salas Salvadó, Jordi, Lapetra, José, Gómez-Gracia, Enrique, Arós, Fernando, Fiol Sala, Miguel, Serra Majem, Lluís, Ros Rahola, Emilio, Estruch Riba, Ramon
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/171703
Acceso en línea:https://hdl.handle.net/2445/171703
Access Level:acceso abierto
Palabra clave:Cuina mediterrània
Dieta
Malalties cardiovasculars
Mediterranean cooking
Diet
Cardiovascular diseases
Descripción
Sumario:Scope: To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals. Methods and results: In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n = 120) or nuts (MedDiet-Nuts; n = 119) versus a low-fat control diet (n = 119), and whether large increments in MedDiet adherence (≥3 score points, versus compliance decreases) and intake changes in key food items are associated with 1-year differences in biomarkers. Differences are observed between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in high-density lipoproteins (HDLs) (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound 1-antitrypsin levels (−6.1% [−11.8; −0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (−9.3% [−18.1; −0.53]). Large MedDiet adherence increments are associated with less fibrinogen (−9.5% [−18.3; −0.60]) and non-esterified fatty acid concentrations (−16.7% [−31.7; −1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake are linked to enhancements in biomarkers. Conclusion: MedDiet improves atherothrombosis biomarkers in high cardiovascular risk individuals.

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