Effects of an onion by-product on bioactivity and safety markers in healthy rats

9 páginas, 3 figuras, 5 tablas.-- et al.

Detalles Bibliográficos
Autores: Roldán-Marín, Eduvigis, Cano, M. Pilar, Sánchez-Moreno, Concepción, Dragsted, Lars O.
Tipo de recurso: artículo
Fecha de publicación:2009
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/34661
Acceso en línea:http://hdl.handle.net/10261/34661
Access Level:acceso abierto
Palabra clave:Onion by-products
Fructo-oligosaccharides
Hb
DNA damage
Antioxidant enzymes
Gene expression
Gut health
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spelling Effects of an onion by-product on bioactivity and safety markers in healthy ratsRoldán-Marín, EduvigisCano, M. PilarSánchez-Moreno, ConcepciónDragsted, Lars O.Onion by-productsFructo-oligosaccharidesHbDNA damageAntioxidant enzymesGene expressionGut health9 páginas, 3 figuras, 5 tablas.-- et al.Onions are excellent sources of bioactive compounds including fructo-oligosaccharides (FOS) and polyphenols. An onion by-product was characterised in order to be developed as a potentially bioactive food ingredient. Our main aim was to investigate whether the potential health and safety effects of this onion by-product were shared by either of two derived fractions, an extract containing the onion FOS and polyphenols and a residue fraction containing mainly cell wall materials. We report here on the effects of feeding these products on markers of potential toxicity, protective enzymes and gut environment in healthy rats. Rats were fed during 4 weeks with a diet containing the products or a control feed balanced in carbohydrate. The onion by-product and the extract caused anaemia as expected in rodents for Allium products. No other toxicity was observed, including genotoxicity. Glutathione reductase (GR) and glutathione peroxidase (GPx1) activities in erythrocytes increased when rats were fed with the onion extract. Hepatic gene expression of Gr, Gpx1, catalase, 5-aminolevulinate synthase and NAD(P)H:quinone oxidoreductase was not altered in any group of the onion fed rats. By contrast, γ-glutamate cysteine ligase catalytic subunit gene expression was upregulated but only in rats given the onion residue. The onion by-products as well as the soluble and insoluble fractions had prebiotic effects as evidenced by decreased pH, increased butyrate production and altered gut microbiota enzyme activities. In conclusion, the onion by-products have no in vivo genotoxicity, may support in vivo antioxidative defence and alter the functionality of the rat gut microbiota.The present study was supported by funding from the Spanish Ministry of Science and Innovation (AGL2003- 09 138-C04-01; 200670I08; Consolider-Ingenio Programme 2010, FUN-C-FOOD, CSD2007-00 063; and AGL2008- 04 798-C02-01/ALI) and from the Danish Ministry of Food, Agriculture and Fisheries (NuBI, 3304-FVFP-060696-01). E. R.-M. wishes to thank the Spanish Ministry of Science and Innovation for a Predoctoral Fellowship.Peer reviewedCambridge University Press201120112009info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/34661reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1017/S0007114509990870info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/346612026-05-22T06:33:51Z
dc.title.none.fl_str_mv Effects of an onion by-product on bioactivity and safety markers in healthy rats
title Effects of an onion by-product on bioactivity and safety markers in healthy rats
spellingShingle Effects of an onion by-product on bioactivity and safety markers in healthy rats
Roldán-Marín, Eduvigis
Onion by-products
Fructo-oligosaccharides
Hb
DNA damage
Antioxidant enzymes
Gene expression
Gut health
title_short Effects of an onion by-product on bioactivity and safety markers in healthy rats
title_full Effects of an onion by-product on bioactivity and safety markers in healthy rats
title_fullStr Effects of an onion by-product on bioactivity and safety markers in healthy rats
title_full_unstemmed Effects of an onion by-product on bioactivity and safety markers in healthy rats
title_sort Effects of an onion by-product on bioactivity and safety markers in healthy rats
dc.creator.none.fl_str_mv Roldán-Marín, Eduvigis
Cano, M. Pilar
Sánchez-Moreno, Concepción
Dragsted, Lars O.
author Roldán-Marín, Eduvigis
author_facet Roldán-Marín, Eduvigis
Cano, M. Pilar
Sánchez-Moreno, Concepción
Dragsted, Lars O.
author_role author
author2 Cano, M. Pilar
Sánchez-Moreno, Concepción
Dragsted, Lars O.
author2_role author
author
author
dc.subject.none.fl_str_mv Onion by-products
Fructo-oligosaccharides
Hb
DNA damage
Antioxidant enzymes
Gene expression
Gut health
topic Onion by-products
Fructo-oligosaccharides
Hb
DNA damage
Antioxidant enzymes
Gene expression
Gut health
description 9 páginas, 3 figuras, 5 tablas.-- et al.
publishDate 2009
dc.date.none.fl_str_mv 2009
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/34661
url http://hdl.handle.net/10261/34661
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1017/S0007114509990870
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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