Pancreatic cancer risk and levels of trace elements
Background and Aims: Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the associat...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2012 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/36543 |
| Acceso en línea: | http://hdl.handle.net/10230/36543 http://dx.doi.org/10.1136/gutjnl-2011-301086 |
| Access Level: | acceso abierto |
| Palabra clave: | Pancreas Arsenic Cadmium Lead Selenium |
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Pancreatic cancer risk and levels of trace elementsAmaral, André F.S.Porta Serra, MiquelSilverman, Debra T.Milne, Roger L.Kogevinas, ManolisRothman, NathanielCantor, Kenneth PJackson, Brian P.Pumarega Rodríguez, José AntonioLópez, TomàsCarrato, AlfredoGuarner, LuisaReal, Francisco X.Malats i Riera, NúriaPancreasArsenicCadmiumLeadSeleniumBackground and Aims: Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the association between concentrations of trace elements in toenails and EPC risk. Methods: The study included 118 EPC cases and 399 hospital controls from eastern Spain. Levels of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. OR and 95% CI, adjusted for potential confounders, were calculated using logistic regression. Results: Significantly increased risks of EPC were observed among subjects whose concentrations of cadmium (OR 3.58, 95% CI 1.86 to 6.88; ptrend=5×10−6), arsenic (OR 2.02, 95% CI 1.08 to 3.78; ptrend=0.009) and lead (OR 6.26, 95% CI 2.71 to 14.47; ptrend=3×10−5) were in the highest quartile. High concentrations of selenium (OR 0.05, 95% CI 0.02 to 0.15; ptrend=8×10−11) and nickel (OR 0.27, 95% CI 0.12 to 0.59; ptrend=2×10−4) were inversely associated with the risk of EPC. Conclusion: Novel associations are reported of lead, nickel and selenium toenail concentrations with pancreas cancer risk. Furthermore, the results confirm previous associations with cadmium and arsenic. These novel findings, if replicated in independent studies, would point to an important role of trace elements in pancreatic carcinogenesis.BMJ Publishing Group201920192012info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/36543http://dx.doi.org/10.1136/gutjnl-2011-301086reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésGut. 2012; 61(11):1583-8© BMJ Publishing Group https://gut.bmj.com/content/61/11/1583info:eu-repo/semantics/openAccessoai:recercat.cat:10230/365432026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Pancreatic cancer risk and levels of trace elements |
| title |
Pancreatic cancer risk and levels of trace elements |
| spellingShingle |
Pancreatic cancer risk and levels of trace elements Amaral, André F.S. Pancreas Arsenic Cadmium Lead Selenium |
| title_short |
Pancreatic cancer risk and levels of trace elements |
| title_full |
Pancreatic cancer risk and levels of trace elements |
| title_fullStr |
Pancreatic cancer risk and levels of trace elements |
| title_full_unstemmed |
Pancreatic cancer risk and levels of trace elements |
| title_sort |
Pancreatic cancer risk and levels of trace elements |
| dc.creator.none.fl_str_mv |
Amaral, André F.S. Porta Serra, Miquel Silverman, Debra T. Milne, Roger L. Kogevinas, Manolis Rothman, Nathaniel Cantor, Kenneth P Jackson, Brian P. Pumarega Rodríguez, José Antonio López, Tomàs Carrato, Alfredo Guarner, Luisa Real, Francisco X. Malats i Riera, Núria |
| author |
Amaral, André F.S. |
| author_facet |
Amaral, André F.S. Porta Serra, Miquel Silverman, Debra T. Milne, Roger L. Kogevinas, Manolis Rothman, Nathaniel Cantor, Kenneth P Jackson, Brian P. Pumarega Rodríguez, José Antonio López, Tomàs Carrato, Alfredo Guarner, Luisa Real, Francisco X. Malats i Riera, Núria |
| author_role |
author |
| author2 |
Porta Serra, Miquel Silverman, Debra T. Milne, Roger L. Kogevinas, Manolis Rothman, Nathaniel Cantor, Kenneth P Jackson, Brian P. Pumarega Rodríguez, José Antonio López, Tomàs Carrato, Alfredo Guarner, Luisa Real, Francisco X. Malats i Riera, Núria |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Pancreas Arsenic Cadmium Lead Selenium |
| topic |
Pancreas Arsenic Cadmium Lead Selenium |
| description |
Background and Aims: Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the association between concentrations of trace elements in toenails and EPC risk. Methods: The study included 118 EPC cases and 399 hospital controls from eastern Spain. Levels of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. OR and 95% CI, adjusted for potential confounders, were calculated using logistic regression. Results: Significantly increased risks of EPC were observed among subjects whose concentrations of cadmium (OR 3.58, 95% CI 1.86 to 6.88; ptrend=5×10−6), arsenic (OR 2.02, 95% CI 1.08 to 3.78; ptrend=0.009) and lead (OR 6.26, 95% CI 2.71 to 14.47; ptrend=3×10−5) were in the highest quartile. High concentrations of selenium (OR 0.05, 95% CI 0.02 to 0.15; ptrend=8×10−11) and nickel (OR 0.27, 95% CI 0.12 to 0.59; ptrend=2×10−4) were inversely associated with the risk of EPC. Conclusion: Novel associations are reported of lead, nickel and selenium toenail concentrations with pancreas cancer risk. Furthermore, the results confirm previous associations with cadmium and arsenic. These novel findings, if replicated in independent studies, would point to an important role of trace elements in pancreatic carcinogenesis. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2019 2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
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article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/36543 http://dx.doi.org/10.1136/gutjnl-2011-301086 |
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http://hdl.handle.net/10230/36543 http://dx.doi.org/10.1136/gutjnl-2011-301086 |
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Inglés |
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Inglés |
| dc.relation.none.fl_str_mv |
Gut. 2012; 61(11):1583-8 |
| dc.rights.none.fl_str_mv |
© BMJ Publishing Group https://gut.bmj.com/content/61/11/1583 info:eu-repo/semantics/openAccess |
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© BMJ Publishing Group https://gut.bmj.com/content/61/11/1583 |
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openAccess |
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application/pdf application/pdf |
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BMJ Publishing Group |
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BMJ Publishing Group |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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