Biosafety steps in the manufacturing process of spray-dried plasma

Spray dried plasma (SDP) is a functional protein source obtained from blood of healthy animals, approved by the veterinary authorities from animals declared to be fit for slaughter for human consumption. Blood of these animals is collected at the slaughterhouse, treated with an anticoagulant, chille...

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Autores: Blázquez Salvador, Elena|||0000-0001-8115-3225, Rodríguez, Carmen, Ródenas, Jesús, Segalés Coma, Joaquim|||0000-0002-1539-7261, Pujols, Joan|||0000-0002-6940-1529, Polo, Javier|||0000-0003-0990-2230
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:252774
Acceso en línea:https://ddd.uab.cat/record/252774
https://dx.doi.org/urn:doi:10.1186/s40813-020-00155-1
Access Level:acceso abierto
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spelling Biosafety steps in the manufacturing process of spray-dried plasmaa review with emphasis on the use of ultraviolet irradiation as a redundant biosafety procedureBlázquez Salvador, Elena|||0000-0001-8115-3225Rodríguez, CarmenRódenas, JesúsSegalés Coma, Joaquim|||0000-0002-1539-7261Pujols, Joan|||0000-0002-6940-1529Polo, Javier|||0000-0003-0990-2230Spray dried plasma (SDP) is a functional protein source obtained from blood of healthy animals, approved by the veterinary authorities from animals declared to be fit for slaughter for human consumption. Blood of these animals is collected at the slaughterhouse, treated with an anticoagulant, chilled and transported to industrial facilities in which blood is centrifuged to separate the red blood cells from the plasma fraction. Plasma is then concentrated, and spray dried at high temperatures (80 °C throughout its substance) to convert it in a powder. Such method preserves the biological activity of its proteins, mainly albumins and globulins. SDP is mainly used in pig feed diets to significantly improve daily gain, feed intake, production efficiency, and to reduce post-weaning lag caused by the appearance of post-weaning diarrhea. Although SDP is considered a safe product and its manufacturing process consists of several biosafety steps, the security of the SDP is often questioned due to its nature as raw blood by-product, especially when emergent or re-emergent pathogens appear. This review provides an evaluation and validation of the different safety steps present in the manufacturing process of SDP, with special focus on a new redundant pathogen inactivation step, the UV-C irradiation, that may be implemented in the manufacturing process of the SDP. Overall results showed that the manufacturing process of SDP is safe and the UV-C radiation was effective in inactivating a wide range of bacteria and viruses spiked and naturally present in commercially collected liquid animal plasma and it can be implemented as a redundant biosafety step in the manufacturing process of the SDP. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/252774https://dx.doi.org/urn:doi:10.1186/s40813-020-00155-1reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2527742026-06-06T12:50:31Z
dc.title.none.fl_str_mv Biosafety steps in the manufacturing process of spray-dried plasma
a review with emphasis on the use of ultraviolet irradiation as a redundant biosafety procedure
title Biosafety steps in the manufacturing process of spray-dried plasma
spellingShingle Biosafety steps in the manufacturing process of spray-dried plasma
Blázquez Salvador, Elena|||0000-0001-8115-3225
title_short Biosafety steps in the manufacturing process of spray-dried plasma
title_full Biosafety steps in the manufacturing process of spray-dried plasma
title_fullStr Biosafety steps in the manufacturing process of spray-dried plasma
title_full_unstemmed Biosafety steps in the manufacturing process of spray-dried plasma
title_sort Biosafety steps in the manufacturing process of spray-dried plasma
dc.creator.none.fl_str_mv Blázquez Salvador, Elena|||0000-0001-8115-3225
Rodríguez, Carmen
Ródenas, Jesús
Segalés Coma, Joaquim|||0000-0002-1539-7261
Pujols, Joan|||0000-0002-6940-1529
Polo, Javier|||0000-0003-0990-2230
author Blázquez Salvador, Elena|||0000-0001-8115-3225
author_facet Blázquez Salvador, Elena|||0000-0001-8115-3225
Rodríguez, Carmen
Ródenas, Jesús
Segalés Coma, Joaquim|||0000-0002-1539-7261
Pujols, Joan|||0000-0002-6940-1529
Polo, Javier|||0000-0003-0990-2230
author_role author
author2 Rodríguez, Carmen
Ródenas, Jesús
Segalés Coma, Joaquim|||0000-0002-1539-7261
Pujols, Joan|||0000-0002-6940-1529
Polo, Javier|||0000-0003-0990-2230
author2_role author
author
author
author
author
description Spray dried plasma (SDP) is a functional protein source obtained from blood of healthy animals, approved by the veterinary authorities from animals declared to be fit for slaughter for human consumption. Blood of these animals is collected at the slaughterhouse, treated with an anticoagulant, chilled and transported to industrial facilities in which blood is centrifuged to separate the red blood cells from the plasma fraction. Plasma is then concentrated, and spray dried at high temperatures (80 °C throughout its substance) to convert it in a powder. Such method preserves the biological activity of its proteins, mainly albumins and globulins. SDP is mainly used in pig feed diets to significantly improve daily gain, feed intake, production efficiency, and to reduce post-weaning lag caused by the appearance of post-weaning diarrhea. Although SDP is considered a safe product and its manufacturing process consists of several biosafety steps, the security of the SDP is often questioned due to its nature as raw blood by-product, especially when emergent or re-emergent pathogens appear. This review provides an evaluation and validation of the different safety steps present in the manufacturing process of SDP, with special focus on a new redundant pathogen inactivation step, the UV-C irradiation, that may be implemented in the manufacturing process of the SDP. Overall results showed that the manufacturing process of SDP is safe and the UV-C radiation was effective in inactivating a wide range of bacteria and viruses spiked and naturally present in commercially collected liquid animal plasma and it can be implemented as a redundant biosafety step in the manufacturing process of the SDP.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
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dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/252774
https://dx.doi.org/urn:doi:10.1186/s40813-020-00155-1
url https://ddd.uab.cat/record/252774
https://dx.doi.org/urn:doi:10.1186/s40813-020-00155-1
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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