Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses
The gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG production is suggested by the impaired IgG response to pneumococcal vaccines in some IgA-defici...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/219500 |
| Acceso en línea: | https://hdl.handle.net/2445/219500 |
| Access Level: | acceso abierto |
| Palabra clave: | Immunoglobulina G Microbiota intestinal Immunoglobulina A Vacuna antipneumocòccica Immunoglobulin G Gastrointestinal microbiome Immunoglobulin A Pneumococcal vaccine |
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Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responsesGutzeit, CindyGrasset, Emilie K.Matthews, Dean B.Maglione, Paul J.Britton, Graham J.Miller, HalleyMagri, GiulianaTomalin, LewisStapylton, MatthewCanales Herrerias, PabloSominskaia, MusiaGuzman, MauricioPybus, MarcTejedor Vaquero, SoniaRadigan, LinTachó Piñot, RoserMartín Nalda, AndreaGarcía Prat, MarinaMartínez Gallo, MónicaDieli Crimi, RominaClemente, José C.Mehandru, SaurabhSuárez Farinas, MayteFaith, Jeremiah J.Cunningham-Rundles, CharlotteCerutti, AndreaImmunoglobulina GMicrobiota intestinalImmunoglobulina AVacuna antipneumocòccicaImmunoglobulin GGastrointestinal microbiomeImmunoglobulin APneumococcal vaccineThe gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG production is suggested by the impaired IgG response to pneumococcal vaccines in some IgA-deficient patients. Here, we found that antipneumococcal but not total IgG production was impaired in mice with IgA deficiency. The positive effect of gut IgA on antipneumococcal IgG responses started very early in life and could implicate gut bacteria, as these responses were attenuated in germ-free mice recolonized with gut microbes from IgA-deficient donors. IgA could exert this effect by constraining the systemic translocation of gut antigens, which was associated with chronic immune activation, including T cell overexpression of programmed cell death protein 1 (PD-1). This inhibitory receptor may attenuate antipneumococcal IgG production by causing B cell hyporesponsiveness, which improved upon anti-PD-1 treatment. Thus, gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responsesAmerican Association for the Advancement of Science2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/219500Articles publicats en revistes (Biomedicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1126/sciadv.ado9455Science Advances, 2025, vol. 11, num.7https://doi.org/10.1126/sciadv.ado9455cc-by (c) Gutzeit, C et al., 2025http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2195002026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| title |
Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| spellingShingle |
Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses Gutzeit, Cindy Immunoglobulina G Microbiota intestinal Immunoglobulina A Vacuna antipneumocòccica Immunoglobulin G Gastrointestinal microbiome Immunoglobulin A Pneumococcal vaccine |
| title_short |
Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| title_full |
Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| title_fullStr |
Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| title_full_unstemmed |
Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| title_sort |
Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| dc.creator.none.fl_str_mv |
Gutzeit, Cindy Grasset, Emilie K. Matthews, Dean B. Maglione, Paul J. Britton, Graham J. Miller, Halley Magri, Giuliana Tomalin, Lewis Stapylton, Matthew Canales Herrerias, Pablo Sominskaia, Musia Guzman, Mauricio Pybus, Marc Tejedor Vaquero, Sonia Radigan, Lin Tachó Piñot, Roser Martín Nalda, Andrea García Prat, Marina Martínez Gallo, Mónica Dieli Crimi, Romina Clemente, José C. Mehandru, Saurabh Suárez Farinas, Mayte Faith, Jeremiah J. Cunningham-Rundles, Charlotte Cerutti, Andrea |
| author |
Gutzeit, Cindy |
| author_facet |
Gutzeit, Cindy Grasset, Emilie K. Matthews, Dean B. Maglione, Paul J. Britton, Graham J. Miller, Halley Magri, Giuliana Tomalin, Lewis Stapylton, Matthew Canales Herrerias, Pablo Sominskaia, Musia Guzman, Mauricio Pybus, Marc Tejedor Vaquero, Sonia Radigan, Lin Tachó Piñot, Roser Martín Nalda, Andrea García Prat, Marina Martínez Gallo, Mónica Dieli Crimi, Romina Clemente, José C. Mehandru, Saurabh Suárez Farinas, Mayte Faith, Jeremiah J. Cunningham-Rundles, Charlotte Cerutti, Andrea |
| author_role |
author |
| author2 |
Grasset, Emilie K. Matthews, Dean B. Maglione, Paul J. Britton, Graham J. Miller, Halley Magri, Giuliana Tomalin, Lewis Stapylton, Matthew Canales Herrerias, Pablo Sominskaia, Musia Guzman, Mauricio Pybus, Marc Tejedor Vaquero, Sonia Radigan, Lin Tachó Piñot, Roser Martín Nalda, Andrea García Prat, Marina Martínez Gallo, Mónica Dieli Crimi, Romina Clemente, José C. Mehandru, Saurabh Suárez Farinas, Mayte Faith, Jeremiah J. Cunningham-Rundles, Charlotte Cerutti, Andrea |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Immunoglobulina G Microbiota intestinal Immunoglobulina A Vacuna antipneumocòccica Immunoglobulin G Gastrointestinal microbiome Immunoglobulin A Pneumococcal vaccine |
| topic |
Immunoglobulina G Microbiota intestinal Immunoglobulina A Vacuna antipneumocòccica Immunoglobulin G Gastrointestinal microbiome Immunoglobulin A Pneumococcal vaccine |
| description |
The gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG production is suggested by the impaired IgG response to pneumococcal vaccines in some IgA-deficient patients. Here, we found that antipneumococcal but not total IgG production was impaired in mice with IgA deficiency. The positive effect of gut IgA on antipneumococcal IgG responses started very early in life and could implicate gut bacteria, as these responses were attenuated in germ-free mice recolonized with gut microbes from IgA-deficient donors. IgA could exert this effect by constraining the systemic translocation of gut antigens, which was associated with chronic immune activation, including T cell overexpression of programmed cell death protein 1 (PD-1). This inhibitory receptor may attenuate antipneumococcal IgG production by causing B cell hyporesponsiveness, which improved upon anti-PD-1 treatment. Thus, gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/219500 |
| url |
https://hdl.handle.net/2445/219500 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1126/sciadv.ado9455 Science Advances, 2025, vol. 11, num.7 https://doi.org/10.1126/sciadv.ado9455 |
| dc.rights.none.fl_str_mv |
cc-by (c) Gutzeit, C et al., 2025 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by (c) Gutzeit, C et al., 2025 http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
15 p. application/pdf |
| dc.publisher.none.fl_str_mv |
American Association for the Advancement of Science |
| publisher.none.fl_str_mv |
American Association for the Advancement of Science |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Biomedicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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15.81155 |