Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses

The gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG production is suggested by the impaired IgG response to pneumococcal vaccines in some IgA-defici...

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Detalles Bibliográficos
Autores: Gutzeit, Cindy, Grasset, Emilie K., Matthews, Dean B., Maglione, Paul J., Britton, Graham J., Miller, Halley, Magri, Giuliana, Tomalin, Lewis, Stapylton, Matthew, Canales Herrerias, Pablo, Sominskaia, Musia, Guzman, Mauricio, Pybus, Marc, Tejedor Vaquero, Sonia, Radigan, Lin, Tachó Piñot, Roser, Martín Nalda, Andrea, García Prat, Marina, Martínez Gallo, Mónica, Dieli Crimi, Romina, Clemente, José C., Mehandru, Saurabh, Suárez Farinas, Mayte, Faith, Jeremiah J., Cunningham-Rundles, Charlotte, Cerutti, Andrea
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219500
Acceso en línea:https://hdl.handle.net/2445/219500
Access Level:acceso abierto
Palabra clave:Immunoglobulina G
Microbiota intestinal
Immunoglobulina A
Vacuna antipneumocòccica
Immunoglobulin G
Gastrointestinal microbiome
Immunoglobulin A
Pneumococcal vaccine
Descripción
Sumario:The gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG production is suggested by the impaired IgG response to pneumococcal vaccines in some IgA-deficient patients. Here, we found that antipneumococcal but not total IgG production was impaired in mice with IgA deficiency. The positive effect of gut IgA on antipneumococcal IgG responses started very early in life and could implicate gut bacteria, as these responses were attenuated in germ-free mice recolonized with gut microbes from IgA-deficient donors. IgA could exert this effect by constraining the systemic translocation of gut antigens, which was associated with chronic immune activation, including T cell overexpression of programmed cell death protein 1 (PD-1). This inhibitory receptor may attenuate antipneumococcal IgG production by causing B cell hyporesponsiveness, which improved upon anti-PD-1 treatment. Thus, gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses

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