Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response
Background. Liver stiffness (LS) is not reduced in 10%–30% of patients who achieve sustained viral response (SVR) after hepatitis C virus (HCV) elimination with direct-acting antivirals (DAA). Our aim was to analyze whether the parameters associated with cellular aging measured at the DAA initiation...
| Autores: | , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Instituto Valenciano de Investigaciones Agrarias (IVIA) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/172665 |
| Acceso en línea: | https://hdl.handle.net/11441/172665 https://doi.org/10.1093/infdis/jiaf087 |
| Access Level: | acceso abierto |
| Palabra clave: | Cellular aging Liver stiffness Telomere length SVR DAA. |
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Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral ResponseGonzález-Serna Martín, Manuel AlejandroCorma Gómez, AnaïsCano Rodríguez, María MercedesRubio Sánchez, RicardoMartín Sierra, CarmenRincón, PilarMartín Carmona, JesicaPérez, MargaritaPineda Vergara, Juan AntonioReal Navarrete, Luis MiguelMacías Sánchez, JuanCellular agingLiver stiffnessTelomere lengthSVRDAA.Background. Liver stiffness (LS) is not reduced in 10%–30% of patients who achieve sustained viral response (SVR) after hepatitis C virus (HCV) elimination with direct-acting antivirals (DAA). Our aim was to analyze whether the parameters associated with cellular aging measured at the DAA initiation date are related to LS reduction upon achieving SVR. Methods. In a prospective cohort study (GEHEP-011) we measured several parameters associated with cellular aging, such as telomere attrition, mitochondrial alterations, and soluble biomarkers associated with senescence-associated secretory phenotype at the DAA initiation date, and examined their associations with a significant (≥20%) LS decrease at the SVR time point. Results. In total, 175 individuals were included in this study. In 101 (57.7%) patients, the LS reduction was ≥20% at SVR. In the multivariate analysis adjusted for sex, age, CXCL10, hsPCR, and CCL11 levels, greater relative telomere length (RTL) emerged as the sole variable independently associated with a significant LS decrease in SVR (1.102; 95% confidence interval, 1.001–1.1214; P = .047). Furthermore, changes in LS, including significant decrease, decrease <20%, or increase, were congruently associated with RTL (P = .011). Conclusions. Greater RTL was independently associated with a significant LS reduction in SVR. Thus, increased cellular aging may be responsible for the absence of liver regeneration after HCV eradication. Further studies are required to assess the long-term effects of cellular aging after SVR.OxfordFisiologíaMedicinaInstituto de Salud Carlos III2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/172665https://doi.org/10.1093/infdis/jiaf087reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Instituto Valenciano de Investigaciones Agrarias (IVIA)InglésThe Journal of Infectious Diseases, jiaf087.PI20/01457https://doi.org/10.1093/infdis/jiaf087info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1726652026-06-17T12:51:07Z |
| dc.title.none.fl_str_mv |
Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response |
| title |
Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response |
| spellingShingle |
Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response González-Serna Martín, Manuel Alejandro Cellular aging Liver stiffness Telomere length SVR DAA. |
| title_short |
Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response |
| title_full |
Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response |
| title_fullStr |
Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response |
| title_full_unstemmed |
Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response |
| title_sort |
Influence of Cellular Aging on Liver Stiffness in Patients With Hepatitis C Virus Achieving Sustained Viral Response |
| dc.creator.none.fl_str_mv |
González-Serna Martín, Manuel Alejandro Corma Gómez, Anaïs Cano Rodríguez, María Mercedes Rubio Sánchez, Ricardo Martín Sierra, Carmen Rincón, Pilar Martín Carmona, Jesica Pérez, Margarita Pineda Vergara, Juan Antonio Real Navarrete, Luis Miguel Macías Sánchez, Juan |
| author |
González-Serna Martín, Manuel Alejandro |
| author_facet |
González-Serna Martín, Manuel Alejandro Corma Gómez, Anaïs Cano Rodríguez, María Mercedes Rubio Sánchez, Ricardo Martín Sierra, Carmen Rincón, Pilar Martín Carmona, Jesica Pérez, Margarita Pineda Vergara, Juan Antonio Real Navarrete, Luis Miguel Macías Sánchez, Juan |
| author_role |
author |
| author2 |
Corma Gómez, Anaïs Cano Rodríguez, María Mercedes Rubio Sánchez, Ricardo Martín Sierra, Carmen Rincón, Pilar Martín Carmona, Jesica Pérez, Margarita Pineda Vergara, Juan Antonio Real Navarrete, Luis Miguel Macías Sánchez, Juan |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Fisiología Medicina Instituto de Salud Carlos III |
| dc.subject.none.fl_str_mv |
Cellular aging Liver stiffness Telomere length SVR DAA. |
| topic |
Cellular aging Liver stiffness Telomere length SVR DAA. |
| description |
Background. Liver stiffness (LS) is not reduced in 10%–30% of patients who achieve sustained viral response (SVR) after hepatitis C virus (HCV) elimination with direct-acting antivirals (DAA). Our aim was to analyze whether the parameters associated with cellular aging measured at the DAA initiation date are related to LS reduction upon achieving SVR. Methods. In a prospective cohort study (GEHEP-011) we measured several parameters associated with cellular aging, such as telomere attrition, mitochondrial alterations, and soluble biomarkers associated with senescence-associated secretory phenotype at the DAA initiation date, and examined their associations with a significant (≥20%) LS decrease at the SVR time point. Results. In total, 175 individuals were included in this study. In 101 (57.7%) patients, the LS reduction was ≥20% at SVR. In the multivariate analysis adjusted for sex, age, CXCL10, hsPCR, and CCL11 levels, greater relative telomere length (RTL) emerged as the sole variable independently associated with a significant LS decrease in SVR (1.102; 95% confidence interval, 1.001–1.1214; P = .047). Furthermore, changes in LS, including significant decrease, decrease <20%, or increase, were congruently associated with RTL (P = .011). Conclusions. Greater RTL was independently associated with a significant LS reduction in SVR. Thus, increased cellular aging may be responsible for the absence of liver regeneration after HCV eradication. Further studies are required to assess the long-term effects of cellular aging after SVR. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/11441/172665 https://doi.org/10.1093/infdis/jiaf087 |
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https://hdl.handle.net/11441/172665 https://doi.org/10.1093/infdis/jiaf087 |
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Inglés |
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Inglés |
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The Journal of Infectious Diseases, jiaf087. PI20/01457 https://doi.org/10.1093/infdis/jiaf087 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
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Oxford |
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Oxford |
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reponame:idUS. Depósito de Investigación de la Universidad de Sevilla instname:Instituto Valenciano de Investigaciones Agrarias (IVIA) |
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Instituto Valenciano de Investigaciones Agrarias (IVIA) |
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idUS. Depósito de Investigación de la Universidad de Sevilla |
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idUS. Depósito de Investigación de la Universidad de Sevilla |
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